Neural mechanisms underlying photophobia and dry eye
畏光和干眼症的神经机制
基本信息
- 批准号:10704725
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-04-01 至 2024-03-31
- 项目状态:已结题
- 来源:
- 关键词:Activities of Daily LivingAcuteAddressAffectAftercareAgeAlgorithmsAutomobile DrivingBilateralBotulinum ToxinsCell NucleusCentral Nervous SystemChronicComputersControl GroupsCorneaCorneal InjuryCutaneousDarknessDataDiagnosisDiseaseDistressDrynessEsthesiaEventEyeFunctional Magnetic Resonance ImagingFunctional disorderGlassGoalsHomeImageIndividualIntrinsic driveKnowledgeLightMeasuresMedialMorbidity - disease rateNerveNerve BlockNeural PathwaysNeuronal PlasticityNociceptionPainPain MeasurementParticipantPathologicPathway interactionsPatientsPeripheralPhotophobiaPhysical FunctionPopulationPositioning AttributePrisonerProcessPulvinar structureQuality of lifeReadingRehabilitation therapyReportingRetinal Ganglion CellsScanningSeveritiesSignal TransductionSigns and SymptomsSomatosensory CortexStimulusStructure of trigeminal ganglionSymptomsSyndromeSystemTechnologyTestingThalamic structureTherapeuticTrigeminal NucleiTrigeminal SystemVeteransVisionWorkblood oxygen level dependentbotulinum neurotoxin injectionclinical paincomparison controldesigneffective therapyexperienceeye drynessimprovedindividual patientinstrumentmelanopsinmental functionmultidisciplinaryneuralneuromechanismocular painpain sensationpain symptompainful neuropathypatient subsetsprecision medicineprogramsresponsesexsocialstatisticssunglassestargeted treatmenttooltreatment responsetreatment strategy
项目摘要
It is estimated that 19% of US veterans have dry eye (DE), of which painful ocular symptoms are a common
manifestation. These can include sensations of dryness, burning, and extreme sensitivity to light (i.e.,
photophobia). The symptoms interfere with activities of daily living including driving and reading. Photophobia,
in particular, is one of the most distressing symptoms as its occurrence results in high morbidity without effective
treatment. Individuals most severely affected become prisoners in their own homes due to intolerance to even
small amounts of light. Even in less severe cases, most individuals have significant functional limitations and
often require sunglasses in and outdoors. A knowledge gap exists with regards to the mechanism that underlie
these painful sensations, thus limiting the ability to target appropriate treatment strategies. Our overall hypothesis
is that photophobia is an indicator of central pathologic plasticity of 1) trigeminal pathways, and 2) their interaction
with melanopsin pathways. To test this hypothesis, in aim 1, we define peripheral and central neural responses
to light in individuals with chronic ocular pain and photophobia as compared to controls. In aim 2, we examine
the contribution of different pathways to photophobia by blocking corneal afferent drive (to assess trigeminal
pathways) and intrinsically photosensitive retinal ganglion cell (ipRGC) drive (to assess melanopsin pathways).
In Aim 3, we determine the effect of neural blockade with botulinum toxin injection on photophobia. This study is
greatly needed, as a critical barrier to progress in the field is the lack of information on neural pathways that
underlie disease. The data generated can be used to improve the rehabilitation of ocular pain and increase
function and quality of life in veterans and non-veterans alike.
据估计,19%的美国退伍军人患有干眼症(DE),其中眼部疼痛症状是常见的
显化。这些症状可能包括干燥感、灼热感和对光的极度敏感(即,
恐光症)。这些症状干扰了日常生活活动,包括驾驶和阅读。恐光症,
尤其是最令人痛苦的症状之一,因为它的发生导致了高发病率而没有有效的
治疗。受影响最严重的个人成为自己家中的囚犯,因为即使
少量的光。即使在不太严重的情况下,大多数人也有明显的功能限制和
经常需要在室内和室外佩戴太阳镜。关于作为基础的机制存在着知识鸿沟
这些痛苦的感觉,从而限制了针对适当的治疗策略的能力。我们的总体假设
恐光是1)三叉神经通路和2)三叉神经通路相互作用的中枢病理可塑性的指标
通过黑素途径。为了验证这一假设,在目标1中,我们定义了外周和中枢神经反应
与对照组相比,慢性眼痛和畏光患者的光线。在目标2中,我们检查
通过阻断角膜传入驱动(评估三叉神经)不同通路在畏光中的作用
和固有的光敏视网膜神经节细胞(IpRGC)驱动(以评估黑素途径)。
在目的3中,我们确定了神经阻滞联合肉毒杆菌毒素注射治疗畏光的效果。这项研究是
作为该领域取得进展的一个关键障碍,迫切需要的是缺乏关于神经通路的信息
潜伏的疾病。所产生的数据可以用于改善眼痛的康复和增加
退伍军人和非退伍军人的功能和生活质量相同。
项目成果
期刊论文数量(27)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
3d Transition Metal Adsorption Induced the valley-polarized Anomalous Hall Effect in Germanene.
- DOI:10.1038/srep27830
- 发表时间:2016-06-17
- 期刊:
- 影响因子:4.6
- 作者:Zhou P;Sun LZ
- 通讯作者:Sun LZ
Maximizing the Spread of Influence via Generalized Degree Discount.
- DOI:10.1371/journal.pone.0164393
- 发表时间:2016
- 期刊:
- 影响因子:3.7
- 作者:Wang X;Zhang X;Zhao C;Yi D
- 通讯作者:Yi D
Development and Evaluation of Loop-Mediated Isothermal Amplification Assay for Rapid Detection of Tylenchulus semipenetrans Using DNA Extracted from Soil.
- DOI:10.5423/ppj.oa.10.2016.0224
- 发表时间:2017-04
- 期刊:
- 影响因子:0
- 作者:Song ZQ;Cheng JE;Cheng FX;Zhang DY;Liu Y
- 通讯作者:Liu Y
Is blue light a red herring in a rodent model of "computer vision syndrome"?
在“计算机视觉综合症”啮齿动物模型中,蓝光是转移注意力的吗?
- DOI:10.1097/j.pain.0000000000002941
- 发表时间:2023
- 期刊:
- 影响因子:7.4
- 作者:Moulton,EricA;Galor,Anat;Ciolino,JosephB;Jacobs,DeborahS
- 通讯作者:Jacobs,DeborahS
Botulinum toxin A decreases neural activity in pain-related brain regions in individuals with chronic ocular pain and photophobia.
- DOI:10.3389/fnins.2023.1202341
- 发表时间:2023
- 期刊:
- 影响因子:4.3
- 作者:Reyes, Nicholas;Huang, Jaxon J.;Choudhury, Anjalee;Pondelis, Nicholas;Locatelli, Elyana V.;Felix, Elizabeth R.;Pattany, Pradip M.;Galor, Anat;Moulton, Eric A.
- 通讯作者:Moulton, Eric A.
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Anat Galor其他文献
Anat Galor的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Anat Galor', 18)}}的其他基金
Defining bacterial members of the ocular surface microbiome and assessing stability over time
定义眼表微生物组的细菌成员并评估随时间推移的稳定性
- 批准号:
10668753 - 财政年份:2023
- 资助金额:
-- - 项目类别:
Lipid mediators and their signaling in ocular surface inflammation and meibomian gland dysfunction
眼表炎症和睑板腺功能障碍中的脂质介质及其信号传导
- 批准号:
10013711 - 财政年份:2020
- 资助金额:
-- - 项目类别:
Lipid mediators and their signaling in ocular surface inflammation and meibomian gland dysfunction
眼表炎症和睑板腺功能障碍中的脂质介质及其信号传导
- 批准号:
10514592 - 财政年份:2020
- 资助金额:
-- - 项目类别:
Lipid mediators and their signaling in ocular surface inflammation and meibomian gland dysfunction
眼表炎症和睑板腺功能障碍中的脂质介质及其信号传导
- 批准号:
10293544 - 财政年份:2020
- 资助金额:
-- - 项目类别:
相似海外基金
Transcriptional assessment of haematopoietic differentiation to risk-stratify acute lymphoblastic leukaemia
造血分化的转录评估对急性淋巴细胞白血病的风险分层
- 批准号:
MR/Y009568/1 - 财政年份:2024
- 资助金额:
-- - 项目类别:
Fellowship
Combining two unique AI platforms for the discovery of novel genetic therapeutic targets & preclinical validation of synthetic biomolecules to treat Acute myeloid leukaemia (AML).
结合两个独特的人工智能平台来发现新的基因治疗靶点
- 批准号:
10090332 - 财政年份:2024
- 资助金额:
-- - 项目类别:
Collaborative R&D
Acute senescence: a novel host defence counteracting typhoidal Salmonella
急性衰老:对抗伤寒沙门氏菌的新型宿主防御
- 批准号:
MR/X02329X/1 - 财政年份:2024
- 资助金额:
-- - 项目类别:
Fellowship
Cellular Neuroinflammation in Acute Brain Injury
急性脑损伤中的细胞神经炎症
- 批准号:
MR/X021882/1 - 财政年份:2024
- 资助金额:
-- - 项目类别:
Research Grant
STTR Phase I: Non-invasive focused ultrasound treatment to modulate the immune system for acute and chronic kidney rejection
STTR 第一期:非侵入性聚焦超声治疗调节免疫系统以治疗急性和慢性肾排斥
- 批准号:
2312694 - 财政年份:2024
- 资助金额:
-- - 项目类别:
Standard Grant
Combining Mechanistic Modelling with Machine Learning for Diagnosis of Acute Respiratory Distress Syndrome
机械建模与机器学习相结合诊断急性呼吸窘迫综合征
- 批准号:
EP/Y003527/1 - 财政年份:2024
- 资助金额:
-- - 项目类别:
Research Grant
FITEAML: Functional Interrogation of Transposable Elements in Acute Myeloid Leukaemia
FITEAML:急性髓系白血病转座元件的功能研究
- 批准号:
EP/Y030338/1 - 财政年份:2024
- 资助金额:
-- - 项目类别:
Research Grant
KAT2A PROTACs targetting the differentiation of blasts and leukemic stem cells for the treatment of Acute Myeloid Leukaemia
KAT2A PROTAC 靶向原始细胞和白血病干细胞的分化,用于治疗急性髓系白血病
- 批准号:
MR/X029557/1 - 财政年份:2024
- 资助金额:
-- - 项目类别:
Research Grant
ロボット支援肝切除術は真に低侵襲なのか?acute phaseに着目して
机器人辅助肝切除术真的是微创吗?
- 批准号:
24K19395 - 财政年份:2024
- 资助金额:
-- - 项目类别:
Grant-in-Aid for Early-Career Scientists