Dry Eye and Microenvironment
干眼与微环境
基本信息
- 批准号:10011823
- 负责人:
- 金额:$ 37.71万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-09-01 至 2023-08-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAffectAgeAir PollutantsAir PollutionAllergensAmericanAntioxidantsAreaCellular PhoneCharacteristicsCitiesClimateClinicClinicalClinical assessmentsComplex MixturesDataDevelopmentDietDiseaseDrynessEconometric ModelsEnvironmental Risk FactorEpithelialEpitheliumEthnic OriginExclusion CriteriaExposure toEyeEye InfectionsFatty AcidsFrequenciesGasesGenderGoalsHome environmentHormonal ChangeHumidityImmunologyIndividualIndoor Air PollutionIndoor environmentInflammationInstitutesInternetInterventionKnowledgeLife StyleLightLiteratureLocationMarylandMeasurementMeasuresMeteorologyModelingMonitorMorbidity - disease rateNational Eye InstituteOphthalmologyPainParticipantParticulate MatterPatientsPatternPlant RootsProductionPublic HealthPublishingQuality of lifeRaceReadingRedwoodReportingResearchRoleSeasonsSeveritiesSigns and SymptomsSmokingSourceSwimmingSymptomsTelephoneTemperatureTestingTimeToxicologyUniversitiesVisionVisitWaterWorkambient air pollutionbasecase controlclinical examinationcomorbiditycost effectivedesignenvironmental interventionevaporationeye drynessfood consumptionhormone therapyimprovedinclusion criteriaindoor exposurelaboratory facilitynovelocular painpersistent symptompollutantportabilitypreventprospectivepublic health relevancerecruitsensorsmartphone Applicationspatiotemporalvolatile organic compound
项目摘要
Project Summary: Dry eye (DE), characterized by a myriad of signs (e.g. decreased tear production,
increased evaporation, and inflammation) and symptoms (e.g. pain, blurry vision and dryness), is a debilitating
disease that affects quality of life. Many patients have persistent symptoms, because the available clinical
therapies are not adequate to manage DE. Thus, managing DE requires solutions (i.e. beyond individual-
level clinical interventions). An emerging literature suggests that environmental conditions can contribute to the
onset and persistence of DE. Our microenvironment is a complex mixture of particulate matter (PM), gaseous
air pollutants and allergens. However, individual specific data on microenvironment are not available. The
project will test two novel hypotheses: 1) the clinical manifestations, measured by the types and severity
of different measures of DE, vary with respect to types, levels and sources of air pollutants, allergens,
humidity and temperature, specifically, exposure to PM, bioaerosols and gaseous pollutants is associated
with epithelial disruption (ED), inflammation and evaporative tear deficiency (ETD), respectively; 2) DE signs
are more strongly associated with indoor relative to outdoor air pollution, as we spend more time indoors
and our indoor exposure dominates our total exposure to microenvironmental conditions. To test these
hypotheses, we propose a prospective case-control design. We will recruit 360 subjects from Bascom
Palmer Eye Institute (BPEI), ranked as the number 1 eye institute in the US consecutively for the past 12
years, and University of Maryland Ophthalmology – Redwood (UMOR) clinics. 180 cases and age-,
gender- and race/ethnicity-matched 180 controls will be determined after their clinical exams. Subjects who
meet the inclusion criteria and have at least one of the three measures of DE, namely ED, inflammation, and
ETD, will serve as cases, and controls will be free from these DE signs, and will meet inclusion criteria. Each
subject will undergo four clinical exams one in each of the four seasons, and a weeklong intensive air pollution
monitoring inside and outside their homes before the clinical exam. PRECISE (precise.ccs.miami.edu), our
portable battery of direct-reading sensors, will measure air pollution in each subject's home for one full year.
Over the same week, participants will record DE symptoms through web or phone. We will calculate time-
weighted indoor and outdoor exposures, and model the effects of exposure on DE signs and symptoms using
spatial econometric models. Our interdisciplinary team has the state-of-the-art laboratory facilities for clinical
assessment of DE and exposure assessment as well as a collaborative track-record over four years. This
project will generate knowledge that will potentially provide a new line of home-based environmental treatment
to manage DE. This research aligns with the “ocular infection, inflammation and immunology” priority
areas of the National Eye Institute (NEI).
项目概述:干眼症(DE),其特征在于无数的体征(例如泪液分泌减少,
蒸发增加和炎症)和症状(例如疼痛,视力模糊和干燥),是一种使人衰弱的
影响生活质量的疾病。许多患者有持续的症状,因为可用的临床
治疗不足以管理DE。因此,管理DE需要解决方案(即超越个人-
临床干预)。一项新的文献表明,环境条件可能有助于
DE的发作和持续性。我们的微环境是一个复杂的混合物颗粒物(PM),气体
空气污染物和过敏原。然而,没有关于微环境的个体特定数据。的
该项目将测试两个新的假设:1)临床表现,通过类型和严重程度来衡量
DE的不同措施,在空气污染物,过敏原,
湿度和温度,特别是暴露于PM,生物气溶胶和气态污染物是相关的
分别伴有上皮破裂(艾德)、炎症和蒸发性泪液缺乏(ETD); 2)DE征
相对于室外空气污染,
我们的室内暴露占了我们对微环境条件的总暴露的主导地位。测试这些
假设,我们提出了一个前瞻性的病例对照设计。我们将从巴斯科姆招募360名受试者
帕尔默眼科研究所(BPEI),在过去的12年里连续被评为美国第一眼科研究所。
年,以及马里兰州眼科大学-雷德伍德(UMOR)诊所。180例,
性别和种族/民族匹配的180名对照将在临床检查后确定。的受试者
符合入选标准,并且具有DE的三个指标中的至少一个,即艾德、炎症和
ETD将作为病例,对照将无这些DE体征,并符合入选标准。每个
受试者将接受四次临床检查,四季各一次,以及为期一周的强烈空气污染
在临床检查之前,在家中和家中进行监测。PRECISE(precise.ccs.miami.edu),我们的
便携式电池的直接读取传感器,将测量空气污染在每个受试者的家中整整一年。
在同一周内,参与者将通过网络或电话记录DE症状。我们会计算时间-
加权室内和室外暴露,并使用以下模型模拟暴露对DE体征和症状的影响
空间计量经济模型我们的跨学科团队拥有最先进的实验室设施,
评估DE和暴露评估以及四年来的合作跟踪记录。这
项目将产生的知识,将有可能提供一个新的路线,以家庭为基础的环境处理
管理DE。这项研究符合“眼部感染,炎症和免疫学”的优先顺序
国家眼科研究所(NEI)
项目成果
期刊论文数量(8)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
OCT Angiography: An Upcoming Non-invasive Tool for Diagnosis of Age-related Macular Degeneration.
- DOI:10.1007/s40135-017-0131-6
- 发表时间:2017-06
- 期刊:
- 影响因子:0.9
- 作者:Roisman L;Goldhardt R
- 通讯作者:Goldhardt R
Role of optical coherence tomography angiography in the characterization of vascular network patterns of ocular surface squamous neoplasia.
- DOI:10.1016/j.jtos.2020.03.009
- 发表时间:2020-10
- 期刊:
- 影响因子:6.4
- 作者:Liu, Zhiping;Karp, Carol L.;Galor, Anat;Al Bayyat, Ghada J.;Jiang, Hong;Wang, Jianhua
- 通讯作者:Wang, Jianhua
Pediatric Asthma Attack and Home Paint Exposure.
- DOI:10.3390/ijerph18084118
- 发表时间:2021-04-13
- 期刊:
- 影响因子:0
- 作者:Saif NT;Janecki JM;Wanner A;Colin AA;Kumar N
- 通讯作者:Kumar N
New Drugs and New Posterior Delivery Methods in CME.
- DOI:10.1007/s40135-017-0134-3
- 发表时间:2017-06
- 期刊:
- 影响因子:0.9
- 作者:de Oliveira Dias JR;Nunes RP;Goldhardt R
- 通讯作者:Goldhardt R
Allergies, Allergic Comorbidities and the Home Environment in Pediatric Asthma in Southern Florida.
- DOI:10.3390/ijerph18084142
- 发表时间:2021-04-14
- 期刊:
- 影响因子:0
- 作者:Saif NT;Kleiner GI;Forster LQ;Hershorin ER;Colin AA;Mirsaeidi M;Kumar N
- 通讯作者:Kumar N
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{{ truncateString('Anat Galor', 18)}}的其他基金
Defining bacterial members of the ocular surface microbiome and assessing stability over time
定义眼表微生物组的细菌成员并评估随时间推移的稳定性
- 批准号:
10668753 - 财政年份:2023
- 资助金额:
$ 37.71万 - 项目类别:
Lipid mediators and their signaling in ocular surface inflammation and meibomian gland dysfunction
眼表炎症和睑板腺功能障碍中的脂质介质及其信号传导
- 批准号:
10013711 - 财政年份:2020
- 资助金额:
$ 37.71万 - 项目类别:
Neural mechanisms underlying photophobia and dry eye
畏光和干眼症的神经机制
- 批准号:
10704725 - 财政年份:2020
- 资助金额:
$ 37.71万 - 项目类别:
Neural mechanisms underlying photophobia and dry eye
畏光和干眼症的神经机制
- 批准号:
10425233 - 财政年份:2020
- 资助金额:
$ 37.71万 - 项目类别:
Lipid mediators and their signaling in ocular surface inflammation and meibomian gland dysfunction
眼表炎症和睑板腺功能障碍中的脂质介质及其信号传导
- 批准号:
10293544 - 财政年份:2020
- 资助金额:
$ 37.71万 - 项目类别:
Neural mechanisms underlying photophobia and dry eye
畏光和干眼症的神经机制
- 批准号:
9885368 - 财政年份:2020
- 资助金额:
$ 37.71万 - 项目类别:
Lipid mediators and their signaling in ocular surface inflammation and meibomian gland dysfunction
眼表炎症和睑板腺功能障碍中的脂质介质及其信号传导
- 批准号:
10514592 - 财政年份:2020
- 资助金额:
$ 37.71万 - 项目类别:
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