Dr. William Coleman Award

威廉·科尔曼博士奖

• 批准号: 10020089
• 负责人: Anna Maria Napoles
• 金额: $ 6.26万
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10020089
• 关键词: Address; Affect; African American; American; Area; Atherosclerosis; Autophagocytosis; Award; Bacteria; Biology; Blood; Blood Cells; Blood Vessels; Cancer Family; Cell Lineage; Cell physiology; Cells; Characteristics; Cholesterol; Chronic stress; Communities; Crystal Formation; Data; Development; Disease; Doctor of Philosophy; Endothelial Cells; Environment; Environmental Exposure; Environmental Health; Environmental Risk Factor; European; Extramural Activities; Familial prostate cancer; Functional disorder; Funding; Future; Gastritis; Genetic; Genetic Variation; Health; Heart; Helicobacter Infections; Helicobacter pylori; Immune; Impairment; Individual; Infection; Institutes; Intramural Research Program; Lipopolysaccharide Biosynthesis Pathway; Lung; Malignant neoplasm of prostate; Mentors; Mexican Americans; National Human Genome Research Institute; National Institute of Drug Abuse; National Institute on Aging; National Institute on Alcohol Abuse and Alcoholism; Neighborhoods; Neurobiology; Patients; Postdoctoral Fellow; Recording of previous events; Research; Research Personnel; Research Project Grants; Review Committee; Scientist; Signal Pathway; Sleep; Sleep disturbances; Social Environment; Stomach; Stress; Susceptibility Gene; Tissue-Specific Gene Expression; Training; Ulcer; United States National Institutes of Health; Visit; Washington; Work; adaptive immune response; alcohol use disorder; atherogenesis; biobehavior; cardiometabolism; cardiovascular health; design; ethnic minority population; exome; exome sequencing; health disparity; high risk; imaging genetics; innovation; lipid metabolism; low socioeconomic status; malignant breast neoplasm; malignant stomach neoplasm; member; men; minority health; negative affect; neural circuit; novel; racial and ethnic; racial disparity; single-cell RNA sequencing; sleep health; transcriptome sequencing; translational study; triple-negative invasive breast carcinoma; vascular inflammation

A Coleman award application review committee was convened with members from NIMHD Extramural, DIR, and other ICs. Five applicants were selected for FY19 funding. A description of the recipients and their research projects follows. Yvonne Baumer, Dr. rer. nat (PhD), Staff Scientist, National Heart. Lung, and Blood Institute. Project Title:Elucidating the Impact of Chronic Stress From Social Environment on Endothelial Cell Function and Vascular Biology: A Translational Study to Address Cardiovascular Health Disparities. Researchers aim to determine whether vascular inflammation is a marker of subclinical atherosclerosis that varies among residents of high- and low-SES neighborhoods in Washington, D.C.; whether individuals from low-SES neighborhoods have altered EC lipid metabolism and EC cholesterol crystal formation; and whether patients with stress-related CVD have impaired signaling pathways controlling lysosomal function and autophagy. Researchers also hope to identify novel signaling pathways important to stress-induced atherogenesis and to broaden understanding of how CVD develops and progresses. Jung Shin Byun, PhD, Staff Scientist, National Institute on Minority Health and Health Disparities. Project Title: Single-Cell RNA-Seq to Describe Differences in Immune Cell Profiles Between African American and European American Patients with Triple-Negative Breast Cancer. Using RNA sequencing in African American and European Americans, the researchers aim to identify prevalent differential gene expression in different cell lineages by studying circulating peripheral blood cells and Triplle Negative Breast Cancer infiltrates at the single-cell level. Mehdi Farokhnia, MD and Monica Faulkner, PhD, Post-doctoral Fellows, National Institute on Alcohol Abuse and Alcoholism and National Institute on Drug Abuse. Project Title: Integration of Imaging, Genetics, and Biobehavioral Data to Investigate the Neurobiological Substrates of Racial Disparity Between Black and White Individuals With Alcohol Use Disorder. This project will investigate whether distinct neural circuits and biobehavioral characteristics underlie differences in AUDs development and progression between Black and White individuals, and whether genetic ancestry contributes to neurobiological characterization of racial disparity in relation to AUD. Symielle A. Gaston, PhD, MPH, Postdoctoral Fellow, National Institute on Environmental Health Sciences. Project Title: Identification and Characterization of Environmental Factors Contributing to Disparities in Sleep Health and Cardiometabolic Dysfunction. Members of racial/ethnic minority and low SES groups are more likely than Whites to live in suboptimal sleep environments. Poor sleep can negatively affect cardiometabolic health. Investigators will assess multiple environmental exposures and their relationships with sleep and cardiometabolic health to see if they explain racial/ethnic and SES disparities in poor sleep and cardiometabolic health in the U.S. Deyana Lewis, PhD, MPH, Postdoctoral Visiting Fellow, National Institute on Aging. IRTA Post-doctoral Fellow, National Human Genome Research Institute. Project Title: Whole Exome Sequencing of High Risk African American Prostate Cancer Families. African American (AA) men have the higher rates of prostate cancer (PCa) and are more than twice as likely as men with European ancestry (EA) to die of the disease. Whole exome sequencing (WES) of hereditary prostate cancer (HPC) families can help identify rare susceptibility variants that more often affect AAs. The researchers will sequence exomes to identify genetic variations that contribute to the aggressiveness of PCa in AA men and EAs.

科尔曼奖申请审查委员会由来自NIMHD ExtraWall、DIR和其他IC的成员组成。五名申请者被选为19财年的资助对象。以下是获奖者及其研究项目的描述。 伊冯·鲍默，雷尔医生。NAT(博士)，国家心脏工作人员科学家。肺和血液研究所。项目标题：阐明来自社会环境的慢性应激对血管内皮细胞功能和血管生物学的影响：一项解决心血管健康差异的翻译研究。研究人员的目标是确定血管炎症是否是亚临床动脉粥样硬化的标志，这种疾病在华盛顿特区高SES和低SES社区的居民中各不相同；SES低社区的个体是否改变了EC脂代谢和EC胆固醇晶体形成；以及与应激相关的CVD患者是否损害了控制溶酶体功能和自噬的信号通路。研究人员还希望确定对应激诱导的动脉粥样硬化重要的新的信号通路，并扩大对心血管疾病发展和进展的理解。 Jung Shin Byun，博士，国家少数民族健康和健康差距研究所工作人员科学家。项目标题：单细胞RNA-SEQ描述患有三阴性乳腺癌的非裔美国人和欧洲裔美国人之间免疫细胞图谱的差异。利用非裔美国人和欧洲裔美国人的RNA测序，研究人员旨在通过在单细胞水平上研究循环外周血细胞和三联阴性乳腺癌浸润物，确定不同细胞系中普遍存在的差异基因表达。 Mehdi Farokhnia医学博士和Monica Faulkner博士，国家酒精滥用和酒精中毒研究所和国家药物滥用研究所博士后研究员。 项目标题：整合影像、遗传学和生物行为数据，以调查患有酒精使用障碍的黑人和白人之间种族差异的神经生物学基础。这个项目将调查不同的神经回路和生物行为特征是否是黑人和白人之间AUDS发展和进展差异的基础，以及遗传祖先是否有助于AUD种族差异的神经生物学表征。 Symielle A.Gaston，博士，公共卫生硕士，国家环境健康科学研究所博士后研究员。项目标题：确定和表征导致睡眠健康和心脏代谢功能障碍差异的环境因素。种族/少数民族和低SES群体的成员比白人更有可能生活在不理想的睡眠环境中。睡眠不足会对心脏新陈代谢健康产生负面影响。调查人员将评估多种环境暴露及其与睡眠和心脏代谢健康的关系，看看它们是否可以解释美国睡眠不良和心脏代谢健康方面的种族/民族和SES差异。 戴亚娜·刘易斯，博士，公共卫生硕士，国家老龄研究所博士后访问研究员。IRTA国家人类基因组研究所博士后研究员。项目标题：非洲裔美国人前列腺癌高危家系的全外显子组测序。非裔美国人(AA)的前列腺癌(PCA)发病率更高，死于前列腺癌的可能性是欧洲血统(EA)男性的两倍多。遗传性前列腺癌(HPC)家系的全外显子组测序(WES)可以帮助识别更常影响AAs的罕见易感变异。研究人员将对外显子进行测序，以确定导致AA患者和EA患者PCa侵袭性的基因变异。