Neurologic and Reproductive Effects of Hexane on Workers

己烷对工人的神经和生殖影响

• 批准号: 7464584
• 负责人: S Katharine Hammond
• 金额: $ 58.01万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-15 至 2013-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7464584
• 关键词: Acetone; Animals; Area; Atrophic; Binding; Books; Chemicals; Clinical; Cohort Studies; Color; Color vision defect; Data; Discrimination; Disruption; Electroplating; Employment; Epidemiologic Studies; Exposure to; Eye; Fertility; Follicle Stimulating Hormone; Functional disorder; Furniture; Gasoline; Gonadotropins; Health; Hexanes; Hormonal; Human; Impairment; Individual; Industry; International; Knowledge; Laboratories; Life; Male Infertility; Manufactured Baseball; Measurement; Mechanics; Nervous system structure; Neurologic; Neuropathy; Neurotoxins; Occupational Exposure; Organic solvent product; Outcome; Participant; Peripheral Nerves; Peripheral Nervous System Diseases; Population; Pregnancy; Printing; Public Health; Questionnaires; Recording of previous events; Records; Recruitment Activity; Reproductive system; Sampling; San Francisco; Serum; Solvents; Statistical Data Interpretation; Symptoms; Test Result; Testing; Textiles; Threshold Limit Values; Time; Toxic effect; Urine; Vegetable Oils; Visual; Work; abstracting; base; cognitive function; cohort; consumer product; eligible participant; experience; male; member; n-hexane; neuropsychological; neurotoxic; repaired; reproductive; response; sertoli cell; toxicant; urinary

DESCRIPTION (provided by applicant): N-hexane was a component of many degreasing products used by auto mechanics from 1990-2002; its use ceased when several mechanics were identified as having peripheral neuropathy. Exposure data suggested that these workers were exposed to levels of n-hexane less than half the Threshold Limit Value (TLV). Acetone, which has been shown in animal studies to potentiate the effects of n-hexane and increase persistence, was added to these products in 1997. This retrospective cohort study aims to investigate possible persistent neurologic, reproductive and ocular effects of n-hexane and acetone after cessation of exposure. The sample will be drawn from the cohort of mechanics employed in the Bay Area during 1990- 2002. The cohort of potentially exposed workers will be identified through union records (District 190 of the International Association of Machinists and Aerospace Workers). Data will be abstracted from the union records for all potentially eligible participants in the study. Based on knowledge of which employers used hexane-containing products, we will recruit a sample of 600 mechanics who had worked at automotive repair shops that had once used hexane-containing products and another 600 will be recruited from such shops that never used hexane-containing products. Participants will be administered a questionnaire to obtain histories of symptoms experienced and solvent use, as well as demographic data and potential confounder exposures. They will also be administered batteries of tests to assess peripheral nerve function and cognitive function, as well as a test of blue-yellow color discrimination. Urine samples will be collected for measurement of the gonadotropins FSH and LH. Animal evidence indicates that n-hexane may cause testicular atrophy, which would be reflected by raised urinary metabolite levels of the FSH. The questionnaire will also inquire about any fertility problems subjects may have experienced. Individual n- hexane and other solvent exposure profiles will be created on the basis of solvent use and employment histories combined with existing exposure measurements and historical product composition information. Statistical analysis of the data will investigate associations of exposure histories with symptomatology, clinical and laboratory test results, and time-to-pregnancy. These results may provide a basis for reassessment of the current TLV for n-hexane, particularly when it is used in conjunction with acetone. PUBLIC HEALTH RELEVANCE: Hexane is a very widely used chemical in industry, consumer products and gasoline that has known toxic effects, particularly on the nervous system. As hexane exposure is widespread, it is important to understand whether current permitted exposure levels are protective. This study will assess this by investigating possible effects on the nervous system, the reproductive system and the eye in a large group of auto mechanics, many of whom have been exposed to hexane in their work.

描述（由申请人提供）：1990-2002年，正己烷是许多汽车机械脱脂产品的组成部分；当几个机械师被确定为周围神经病变时，停止使用。暴露数据表明，这些工人暴露于正己烷水平低于阈值限值（TLV）的一半。丙酮在1997年被添加到这些产品中，在动物研究中显示，丙酮可以增强正己烷的作用并增加持久性。本回顾性队列研究旨在探讨停止接触正己烷和丙酮后可能的持续性神经、生殖和眼部影响。样本将从1990年至2002年期间在湾区工作的机械师队列中抽取。将通过工会记录（国际机械师和航空航天工人协会第190区）确定潜在暴露的工人群体。数据将从所有可能符合条件的研究参与者的工会记录中提取。根据对哪些雇主使用含己烷产品的了解，我们将招募600名曾经在使用过含己烷产品的汽车维修店工作过的机械师作为样本，另外600名将从从未使用过含己烷产品的汽车维修店招聘。参与者将接受问卷调查，以获得所经历的症状和溶剂使用的历史，以及人口统计数据和潜在的混杂物暴露。他们还将接受一系列测试，以评估周围神经功能和认知功能，以及蓝黄颜色辨别测试。尿液样本将被收集用于测量促性腺激素FSH和LH。动物证据表明，正己烷可能导致睾丸萎缩，这将反映在尿中促卵泡刺激素代谢水平升高。问卷还将询问受试者可能经历过的任何生育问题。单独的正己烷和其他溶剂暴露概况将建立在溶剂使用和就业历史的基础上，结合现有的暴露测量和历史产品成分信息。数据的统计分析将调查暴露史与症状、临床和实验室检测结果以及怀孕时间的关系。这些结果可以为重新评估目前正己烷的TLV提供基础，特别是当它与丙酮结合使用时。公共卫生相关性：己烷是一种在工业、消费品和汽油中广泛使用的化学物质，已知具有毒性作用，特别是对神经系统。由于己烷暴露是广泛的，了解目前的允许暴露水平是否具有保护作用是很重要的。这项研究将通过调查一大批汽车修理工对神经系统、生殖系统和眼睛可能产生的影响来评估这一点，他们中的许多人在工作中都接触过己烷。