Effects of prenatal diet and mercury exposure on child behavior and development

产前饮食和汞接触对儿童行为和发育的影响

• 批准号: 7350505
• 负责人: Emily Oken
• 金额: $ 34.36万
• 依托单位: HARVARD PILGRIM HEALTH CARE, INC.
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-03 至 2012-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7350505
• 关键词: Address; Adverse effects; Age; Attenuated; Behavior; Behavior assessment; Benefits and Risks; Binding; Biological Assay; Biological Markers; Birth; Blood; Blood specimen; Brain; Child; Child Behavior; Child Development; Childhood; Cognition; Cognitive; Cohort Studies; Consumption; Data; Data Analyses; Data Quality; Development; Diet; Dietary Assessment; Emotional; Equilibrium; Evaluation; Exposure to; Fishes; Funding; Grant; Health; Home environment; Hyperactive behavior; Intake; Intelligence; Intelligence quotient; Life; Measures; Mercury; Mothers; Numbers; Nutrient; Nutritional; Omega-3 Fatty Acids; Outcome; Outcome Measure; Participant; Policies; Polyunsaturated Fatty Acids; Positioning Attribute; Predisposition; Pregnancy; Pregnant Women; Public Health; Randomized Controlled Clinical Trials; Range; Recommendation; Research Infrastructure; Risk; Role; Safety; Seafood; Selenium; Supplementation; Symptoms; Test Result; Theoretical model; Time; Toxic effect; Toxicant exposure; Visit; Vocabulary; Woman; cohort; cost; cost effective; design; early childhood; executive function; follow-up; human study; improved; inattention; neurodevelopment; neurotoxicity; nutrient blood level; peer; postnatal; prenatal; toxicant; visual memory

DESCRIPTION (provided by applicant): Fish and other seafood may contain beneficial nutrients as well as harmful contaminants. The prenatal period is a time of particular susceptibility to the adverse effects of organic mercury as well as to the beneficial influence of nutrients such as elongated n-3 fatty acids and selenium. However, little is known about the balance of risk and benefit from maternal fish intake during pregnancy on child development. The small number of previous studies regarding fish intake and child development are limited by lack of detailed nutrient measures, short duration of follow-up, and few outcome measures. In the proposed study, we will use information on maternal fish intake and biomarkers of mercury and nutrient exposure to examine the combined influence of the risks and benefits of maternal diet during pregnancy on child development. This project build upon the established infrastructure of Project Viva, an ongoing pre-birth US cohort study with stored maternal blood samples, validated prenatal dietary assessment, and detailed information on a number of covariates including home environment and other important predictors of child development. Study aims will be to assess associations of levels of mercury and n-3 fatty acids from maternal blood collected during pregnancy with child cognition and behavior at age 7 years. In addition, we will examine the influence of maternal prenatal fish intake on child cognition and behavior, with and without additional adjustment for mercury and n-3 fatty acids. We will explore the role of nutrients as modifiers of the effect of prenatal mercury exposure, by determining whether mercury has a stronger adverse effect among participants with lower levels of elongated n-3 fatty acids or selenium. Funds from this grant will support wide-ranging cognitive and behavioral assessments added to the already-funded cohort follow-up visit at age 7 years, as well as assays of exposure biomarkers and data analysis. This project is both cost- and time-efficient compared to the initiation of a new cohort, and offers many advantages over previous studies. The study team brings internationally recognized expertise in establishing, maintaining, and analyzing data from a longitudinal cohort, in performing and interpreting assays of nutrient and toxicant exposure, and in interpreting cognitive test results. The proposed study will provide information important to helping mothers and their health advisors make the best decisions about diet during pregnancy to optimize child development. The proposed study will provide timely and high quality data to inform the ongoing national policy discussion regarding the nutritional benefits as well as the contaminant risks from fish intake during pregnancy, and how these competing effects may balance out. Getting the message right is crucial, since pregnant women act upon recommendations regarding the safety of dietary fish intake. The right kind of message could improve children's developmental potential, but the wrong message could do the opposite.

描述（由申请人提供）：鱼和其他海鲜可能含有有益的营养成分以及有害的污染物。产前时期特别容易受到有机汞的不利影响，同时也容易受到长链n-3脂肪酸和硒等营养物质的有益影响。然而，关于母亲在怀孕期间摄入鱼类对儿童发育的风险和益处的平衡，人们知之甚少。由于缺乏详细的营养测量，随访时间短，结果测量少，先前关于鱼类摄入和儿童发育的研究数量很少。在拟议的研究中，我们将利用母体鱼类摄入量以及汞和营养素暴露的生物标志物的信息来检查孕期母体饮食对儿童发育的风险和益处的综合影响。该项目建立在Viva项目的基础上，Viva项目是一项正在进行的美国产前队列研究，其中包括储存的母亲血液样本，有效的产前饮食评估，以及许多协变量的详细信息，包括家庭环境和其他重要的儿童发育预测因素。研究目的是评估怀孕期间采集的母亲血液中汞和n-3脂肪酸水平与7岁儿童认知和行为的关系。此外，我们将研究母亲产前摄入鱼类对儿童认知和行为的影响，无论是否对汞和n-3脂肪酸进行额外的调整。我们将探讨营养素作为产前汞暴露影响调节剂的作用，通过确定汞对低水平的长链n-3脂肪酸或硒的参与者是否有更强的不利影响。这笔资金将支持广泛的认知和行为评估，增加到已经资助的7岁队列随访，以及暴露生物标志物和数据分析的分析。与新队列的启动相比，该项目既节省成本又节省时间，并且比以前的研究提供了许多优势。研究团队在建立、维护和分析纵向队列数据、执行和解释营养和毒物暴露分析以及解释认知测试结果方面具有国际公认的专业知识。这项拟议的研究将提供重要的信息，帮助母亲和她们的健康顾问在怀孕期间做出最佳的饮食决定，以优化儿童的发育。拟议的研究将提供及时和高质量的数据，为正在进行的国家政策讨论提供信息，这些讨论涉及怀孕期间摄入鱼类的营养益处和污染物风险，以及这些相互竞争的影响如何平衡。获得正确的信息是至关重要的，因为孕妇会根据有关食用鱼类安全的建议采取行动。正确的信息可以提高孩子的发展潜力，但错误的信息可能适得其反。