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中文摘要
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行政核心 行政核心的目标是将 避孕研究中心。这个拟议中的中心有一个独特的科学主题; 确定体内阻断sAC的最安全和最有效的方法,以实现按需治疗 避孕药为了实现这一目标,CRC利用已经成功的跨- 学科团队由sAC药理学和生物化学、sAC结构 生物学、药物化学和药物开发。为了完成CRC,我们包括 Andrology Core.这一行政核心将确保这一合作者小组发挥作用, 一个单一的实体,并仍然专注于CRC的目标,开发一个非激素, 药物避孕药除了促进 作为组成本CRC的调查员,行政核心将促进 CRC和指定的NICHD项目科学家、NICHD项目人员、研究者 其他CRC和监管机构。核心的行政职责包括规划、 信息流动、开发资源、外联和CRC的总体管理。在 在实践中,CRC行政核心将为已经建立的 CRC研究者和咨询委员会之间的现有关系。
英文摘要
Administrative Core The objective of the Administrative Core is to link together the various elements of the Contraception Research Center (CRC). This proposed center has a singular scientific theme; to identify the safest and most efficacious means for blocking sAC in vivo to achieve an on-demand contraceptive pill. To achieve this goal, the CRC leverages the already successful inter- disciplinary team comprised of expertise in sAC pharmacology and biochemistry, sAC structural biology, and medicinal chemistry and drug development. To complete the CRC, we include an Andrology Core. This Administrative Core will ensure that this group of collaborators functions as a single entity and remains focused on the CRC’s goal to develop a non-hormonal, pharmacological, on-demand contraceptive. Besides facilitating interactions among the investigators that make up this CRC, the administrative core will foster interactions between the CRC and the designated NICHD Project Scientist, NICHD program personnel, investigators in other CRCs, and regulatory agencies. The Core’s administrative responsibilities include planning, flow of information, developing resources, outreach, and overall administration for the CRC. In practice, the CRC Administrative Core will provide a structure and oversight for the already existing relationships between the CRC investigators and the advisory committees.
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Administrative Core
Optimization of in vivo validated ADCY10 inhibitors
Target Engagement
Neuronal growth factor signaling via cAMP
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