Administrative Core

行政核心

基本信息

  • 批准号:
    10747154
  • 负责人:
  • 金额:
    $ 25.12万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-08-10 至 2026-05-31
  • 项目状态:
    未结题

项目摘要

Administrative Core The objective of the Administrative Core is to link together the various elements of the Weill Cornell Medicine Contraception Research Center (WCM-CRC). This center, titled “On-demand nonhormonal male contraception via ADCY10 inhibition,” has a singular scientific theme; to identify the safest and most efficacious means for blocking soluble adenylyl cyclase (sAC; ADCY10) in vivo to achieve an on-demand contraceptive pill for men. To achieve this goal, the WCM-CRC leverages the established inter-disciplinary team comprised of expertise in sAC physiology, pharmacology, biochemistry, reproductive biology, structural biology, enzymology, computational modeling, medicinal chemistry, and drug development. This team, which has been effectively and efficiently working together for the past 4 years, successfully advanced sAC inhibitors into potent, specific, drug-like leads that demonstrated proof-of-concept for on- demand male contraception in vivo in mice. This administrative core mirrors the successful administrative core from the previously funded WCM-CRC; all personnel and operational resources are maintained. Due to the advancements made over the past four years, the WCM-CRC investigative team joined forces with an expert in reproductive biology and an expert in contraceptive marketing and end-user preferences to form Sacyl Pharmaceuticals, Inc. (SACYL), a biotech company established to further develop and market sAC inhibitors as nonhormonal, on-demand birth control pills for men. SACYL will provide `Pharma-quality' drug development expertise to augment the work proposed in this application. In addition to ensuring that the established group of collaborators comprising the WCM-CRC functions as a single entity, the WCM- CRC Administrative Core will be responsible for maintaining complementarity between the WCM-CRC and SACYL as well as fostering interactions between the WCM-CRC and NICHD program personnel, investigators in other CRCs, and regulatory agencies. The Core's administrative responsibilities include planning, flow of information, developing resources, outreach, and overall administration for the WCM- CRC. In practice, the WCM-CRC Administrative Core will provide structure and oversight for the already existing relationships between the two co-Principal Investigators, the other project leaders, SACYL, and the Center's advisory committees.
管理的核心

项目成果

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会议论文数量(0)
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{{ truncateString('LONNY R LEVIN', 18)}}的其他基金

Optimization of in vivo validated ADCY10 inhibitors
体内验证的 ADCY10 抑制剂的优化
  • 批准号:
    10747156
  • 财政年份:
    2023
  • 资助金额:
    $ 25.12万
  • 项目类别:
Target Engagement
目标参与度
  • 批准号:
    10747155
  • 财政年份:
    2023
  • 资助金额:
    $ 25.12万
  • 项目类别:
Neuronal growth factor signaling via cAMP
通过 cAMP 的神经元生长因子信号传导
  • 批准号:
    7342124
  • 财政年份:
    2007
  • 资助金额:
    $ 25.12万
  • 项目类别:
Neuronal growth factor signaling via cAMP
通过 cAMP 的神经元生长因子信号传导
  • 批准号:
    7194673
  • 财政年份:
    2007
  • 资助金额:
    $ 25.12万
  • 项目类别:
Neuronal growth factor signaling via cAMP
通过 cAMP 的神经元生长因子信号传导
  • 批准号:
    7738937
  • 财政年份:
    2007
  • 资助金额:
    $ 25.12万
  • 项目类别:
Neuronal growth factor signaling via cAMP
通过 cAMP 的神经元生长因子信号传导
  • 批准号:
    7535181
  • 财政年份:
    2007
  • 资助金额:
    $ 25.12万
  • 项目类别:
Neuronal growth factor signaling via cAMP
通过 cAMP 的神经元生长因子信号传导
  • 批准号:
    7935631
  • 财政年份:
    2007
  • 资助金额:
    $ 25.12万
  • 项目类别:
A new target for malaria drug development
疟疾药物开发的新目标
  • 批准号:
    7174209
  • 财政年份:
    2005
  • 资助金额:
    $ 25.12万
  • 项目类别:
A new target for malaria drug development
疟疾药物开发的新目标
  • 批准号:
    7327787
  • 财政年份:
    2005
  • 资助金额:
    $ 25.12万
  • 项目类别:
New target for malaria drug development
疟疾药物开发的新目标
  • 批准号:
    6911385
  • 财政年份:
    2005
  • 资助金额:
    $ 25.12万
  • 项目类别:

相似海外基金

Advisory Committees
咨询委员会
  • 批准号:
    7353899
  • 财政年份:
    2006
  • 资助金额:
    $ 25.12万
  • 项目类别:
Toward a Political Theory of Bioethics: Participation, Representation, and Deliberation on Federal Bioethics Advisory Committees
迈向生命伦理学的政治理论:联邦生命伦理学咨询委员会的参与、代表和审议
  • 批准号:
    0451289
  • 财政年份:
    2005
  • 资助金额:
    $ 25.12万
  • 项目类别:
    Standard Grant
Advisory Committees
咨询委员会
  • 批准号:
    7557224
  • 财政年份:
  • 资助金额:
    $ 25.12万
  • 项目类别:
Advisory Committees
咨询委员会
  • 批准号:
    7902286
  • 财政年份:
  • 资助金额:
    $ 25.12万
  • 项目类别:
Advisory Committees
咨询委员会
  • 批准号:
    7691385
  • 财政年份:
  • 资助金额:
    $ 25.12万
  • 项目类别:
Advisory Committees
咨询委员会
  • 批准号:
    8150373
  • 财政年份:
  • 资助金额:
    $ 25.12万
  • 项目类别:
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