Administrative Core
行政核心
基本信息
- 批准号:10747154
- 负责人:
- 金额:$ 25.12万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-08-10 至 2026-05-31
- 项目状态:未结题
- 来源:
- 关键词:Adenylate CyclaseAdvisory CommitteesAffectAnimal ModelBiochemistryBiological AvailabilityBiotechnologyCharacteristicsChemicalsCommunicationComputer ModelsContraceptive AgentsContraceptive methodsCrystallographyDataDrug KineticsElementsEnsureEnzymatic BiochemistryEvaluationFertilizationFosteringFundingGoalsHumanHuman ResourcesInfertilityInstitutionInstitutional Review BoardsInvestigational New Drug ApplicationLeadLinkMaintenanceMale Contraceptive AgentsMarketingMedicineMusNational Institute of Child Health and Human DevelopmentOralOral ContraceptivesPartner in relationshipPharmaceutical ChemistryPharmaceutical PreparationsPharmacologic SubstancePharmacologyPhysiologyPositioning AttributePrincipal InvestigatorPropertyQuality ControlReproductive BiologyResearchResearch ActivityResearch PersonnelResourcesSeriesSperm MotilityStructureTherapeuticTimeWorkcontraceptive efficacydesigndrug developmentdrug discoverydrug qualityearly phase clinical trialimprovedin vivoinhibitormalemating behaviormembermenoutreachpharmacodynamic biomarkerpharmacologicpillpreclinical developmentpreferencepreventprogramsrecruitscaffoldsperm cellstructural biologytool
项目摘要
Administrative Core
The objective of the Administrative Core is to link together the various elements of the Weill Cornell
Medicine Contraception Research Center (WCM-CRC). This center, titled “On-demand nonhormonal male
contraception via ADCY10 inhibition,” has a singular scientific theme; to identify the safest and most
efficacious means for blocking soluble adenylyl cyclase (sAC; ADCY10) in vivo to achieve an on-demand
contraceptive pill for men. To achieve this goal, the WCM-CRC leverages the established inter-disciplinary
team comprised of expertise in sAC physiology, pharmacology, biochemistry, reproductive biology,
structural biology, enzymology, computational modeling, medicinal chemistry, and drug development. This
team, which has been effectively and efficiently working together for the past 4 years, successfully
advanced sAC inhibitors into potent, specific, drug-like leads that demonstrated proof-of-concept for on-
demand male contraception in vivo in mice. This administrative core mirrors the successful administrative
core from the previously funded WCM-CRC; all personnel and operational resources are maintained. Due
to the advancements made over the past four years, the WCM-CRC investigative team joined forces with
an expert in reproductive biology and an expert in contraceptive marketing and end-user preferences to
form Sacyl Pharmaceuticals, Inc. (SACYL), a biotech company established to further develop and market
sAC inhibitors as nonhormonal, on-demand birth control pills for men. SACYL will provide `Pharma-quality'
drug development expertise to augment the work proposed in this application. In addition to ensuring that
the established group of collaborators comprising the WCM-CRC functions as a single entity, the WCM-
CRC Administrative Core will be responsible for maintaining complementarity between the WCM-CRC and
SACYL as well as fostering interactions between the WCM-CRC and NICHD program personnel,
investigators in other CRCs, and regulatory agencies. The Core's administrative responsibilities include
planning, flow of information, developing resources, outreach, and overall administration for the WCM-
CRC. In practice, the WCM-CRC Administrative Core will provide structure and oversight for the already
existing relationships between the two co-Principal Investigators, the other project leaders, SACYL, and
the Center's advisory committees.
管理的核心
项目成果
期刊论文数量(0)
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会议论文数量(0)
专利数量(0)
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{{ truncateString('LONNY R LEVIN', 18)}}的其他基金
Optimization of in vivo validated ADCY10 inhibitors
体内验证的 ADCY10 抑制剂的优化
- 批准号:
10747156 - 财政年份:2023
- 资助金额:
$ 25.12万 - 项目类别:
Neuronal growth factor signaling via cAMP
通过 cAMP 的神经元生长因子信号传导
- 批准号:
7342124 - 财政年份:2007
- 资助金额:
$ 25.12万 - 项目类别:
Neuronal growth factor signaling via cAMP
通过 cAMP 的神经元生长因子信号传导
- 批准号:
7194673 - 财政年份:2007
- 资助金额:
$ 25.12万 - 项目类别:
Neuronal growth factor signaling via cAMP
通过 cAMP 的神经元生长因子信号传导
- 批准号:
7738937 - 财政年份:2007
- 资助金额:
$ 25.12万 - 项目类别:
Neuronal growth factor signaling via cAMP
通过 cAMP 的神经元生长因子信号传导
- 批准号:
7535181 - 财政年份:2007
- 资助金额:
$ 25.12万 - 项目类别:
Neuronal growth factor signaling via cAMP
通过 cAMP 的神经元生长因子信号传导
- 批准号:
7935631 - 财政年份:2007
- 资助金额:
$ 25.12万 - 项目类别:
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