DATA COORDINATING CENTER FOR THE PRENATAL AND CHILDHOOD MECHANISMS OF HEALTH DISPARITIES: START-UP AND RECRUITMENT OF THE FIRST SUBCOHORT OF PREGNANT WOMEN AND THEIR PARTNERS

产前和儿童健康差异机制数据协调中心:第一个孕妇及其伴侣小组的启动和招募

基本信息

  • 批准号:
    10025384
  • 负责人:
  • 金额:
    $ 38.1万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-09-23 至 2020-09-22
  • 项目状态:
    已结题

项目摘要

BACKGROUND Health disparities in the United States have their origins as early as the prenatal period. Early life conditions including poverty and discrimination generate disparities in health over the life course that become further entrenched in the population through their transmission across generations. Parental mental health, which is strongly linked with social and economic disadvantage as well as child development, may play a key mediating role in the transmission of disparities across generation, but a persistent gap in the disparities literature is that both maternal and paternal psychopathology have not been fully considered as mechanisms nor measured using phenotypically validated approaches. As a result, though disparities in health are well documented, the developmental mechanisms that impact disparities at the very beginning of life are not, particularly those which lead to developmental deficits that emerge long before disease states. The National Institutes of Health (NIH) strategic plan (2016-2020) highlights the need for research to improve “understanding mechanisms that lead to disparities by race/ethnicity and socioeconomic status.” Such enhanced understanding is needed to clarify the etiology of disparities – particularly the specific exposures linked with social or economic disadvantage that impact early development. Advancing knowledge of the developmental mechanisms that generate disparities requires a more thorough understanding of how socioeconomic and race/ethnic status influence the determinants of development from gestation onward. To accomplish this, more in-depth measurement of potential causes of disparities is needed from more diverse samples starting earlier in the life course are needed than is currently available from existing studies. A. Study Research Aims The Division of Intramural Population Health Research (DIPHR) is examining evidence-and theory-based risk and protective factors for maternal health during pregnancy and child development that are expected to be affected by inequalities at the individual, family, and neighborhood levels. The results of this study will expand the knowledge base concerning the impacts of disparities on parental health and early child development that may account for the establishment of life-long disparities in health. This knowledge base will, in turn, inform interventional research on effective approaches to the alleviation of disparities. Accordingly, this prospective observational cohort study will enroll a socioeconomically and racially and ethnically diverse cohort totaling approximately 2,000 women and their partners during the first trimester of pregnancy and conduct follow-up assessments through pregnancy, delivery and the first year of their offspring’s life. The specific aims of the overall study are the following: (1) To investigate disparities in parents’ health and behaviors during pregnancy (2) To investigate the mechanisms generating disparities in birth outcomes and child development during the first year of life. B. Study Design The clinical site(s) will enroll a socioeconomically and racially and ethnically diverse sample totaling approximately 2,000 pregnant women and their partners at 12 or fewer gestational weeks. In addition to gestational age, eligibility requirements for participants are that they be noninstitutionalized, able to grant consent (or, if under the age of majority, to obtain parental consent), and able to speak either English or Spanish. The study will include serial collection of quantitative data from multiple sources including structured diagnostic interviews for psychiatric disorders. In addition, anthropometric assessments and biomedical measurements such as weight, height, and blood pressure will be obtained. At baseline, detailed assessments of maternal and paternal prepregnancy physical and mental health and social histories, familial and neighborhood-level risk and protective factors for fetal development will be conducted utilizing structured interviews. Specific domains to be assessed include psychiatric diagnoses, childhood adversities, traumatic and stressful life events, perceived stress and social support, substance use, and eating behavior, as well as intentions to breastfeed and perceived partner support for breastfeeding. Further, participant addresses will be geocoded to enable data on neighborhood-level characteristics to be obtained from public sources. Biospecimens (blood, urine, saliva) will be collected from mothers serially for genotyping and to measure neuroendocrine-immune and metabolic pathways through pregnancy; in addition, blood for genotyping will be collected partners/co-parents at baseline. Maternal biospecimens will be collected and infants’ physical health and neurodevelopment assessed at delivery. Prenatal, labor and delivery, and neonatal medical record abstractions at the end of pregnancy will provide additional data on maternal and fetal conditions during pregnancy and complications during delivery. Follow-up assessments of infants at 6 months and 12 months of age will encompass physical health and neurodevelopment; parenting behaviors and family and neighborhood environments will also be assessed. Between postdelivery study visits, parents will complete interim Real-time assessment of Pregnancy and Parenting Environment for Research, known as RAPPER-based assessments of behaviors, moods, parenting experiences, and children’s growth and development during the first postnatal year. Part of the RAPPER platform will be used to construct an electronic pregnancy/baby “book” that will give back to participants to recognize their families’ study participation. After the 12-month follow-up, pediatric record abstraction will provide additional data on infant health and development. SCOPE The purpose of this task order is to provide services of a Data Coordinating Center for the completion of the start-up, initial recruitment phase, and the beginning of second trimester follow-up assessments in the Prenatal and Childhood Mechanisms of Health Disparities observational study. In collaboration with the clinical study site(s) and DIPHR investigators, theData Coordinating Center is responsible for designing and implementing a system to track participant recruitment, retention, and follow-up over multiple waves of assessment across up to 4 study sites; designing and implementing the data collection platforms for the study; developing and implementing a system to track the ascertainment, shipment, and storage of biospecimens in the NICHD biorepository; developing and implementing a system to ensure data quality and completeness; and providing those data collection and management systems and documentation of study procedures to the Contracting Officer’s Representative (COR).
背景

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Seth Sherman其他文献

Seth Sherman的其他文献

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{{ truncateString('Seth Sherman', 18)}}的其他基金

DATA COORDINATING CENTER TO PROVIDE SERVICES TO WORK COLLABORATIVELY WITH THE NATIONAL NEUROHIV TISSUE CONSORTIUM CLINICAL SITES TO PROVIDE MANAGEMENT AND DATABASE CAPABILITIES, SCIENTIFIC EXPERTISE,
数据协调中心提供服务,与国家神经艾滋病毒组织联盟临床站点合作,提供管理和数据库能力、科学专业知识、
  • 批准号:
    10923530
  • 财政年份:
    2023
  • 资助金额:
    $ 38.1万
  • 项目类别:
DATA COORDINATING CENTER FOR THE PRENATAL AND CHILDHOOD MECHANISMS OF HEALTH DISPARITIES: FOLLOW-UP OF THE FIRST SUBCOHORT AND INITIATION OF RECRUITMENT OF THE SECOND SUBCOHORT OF PREGNANT WOMEN
产前和儿童期健康差异机制数据协调中心:第一小组的后续行动和第二小组孕妇的招募工作
  • 批准号:
    10800843
  • 财政年份:
    2022
  • 资助金额:
    $ 38.1万
  • 项目类别:
DATA COORDINATING CENTER FOR THE PRENATAL AND CHILDHOOD MECHANISMS OF HEALTH DISPARITIES: RECRUITMENT OF THE FIRST SUBCOHORT AND FOLLOW-UP
产前和儿童健康差异机制数据协调中心:第一小组的招募和后续行动
  • 批准号:
    10576717
  • 财政年份:
    2021
  • 资助金额:
    $ 38.1万
  • 项目类别:
DATA COORDINATING CENTER FOR THE PRENATAL AND CHILDHOOD MECHANISMS OF HEALTH DISPARITIES: START-UP AND RECRUITMENT OF THE FIRST SUBCOHORT OF PREGNANT WOMEN AND THEIR PARTNERS
产前和儿童健康差异机制数据协调中心:第一个孕妇及其伴侣小组的启动和招募
  • 批准号:
    10261309
  • 财政年份:
    2019
  • 资助金额:
    $ 38.1万
  • 项目类别:
AMBIENT AIR POLLUTION EXPOSURE DURING PREGNANCY AND LONGITUDINAL FETAL GROWTH
怀孕期间和胎儿纵向生长期间的环境空气污染暴露
  • 批准号:
    10086826
  • 财政年份:
    2018
  • 资助金额:
    $ 38.1万
  • 项目类别:
AMBIENT AIR POLLUTION EXPOSURE DURING PREGNANCY AND LONGITUDINAL FETAL GROWTH
怀孕期间和胎儿纵向生长期间的环境空气污染暴露
  • 批准号:
    9986964
  • 财政年份:
    2018
  • 资助金额:
    $ 38.1万
  • 项目类别:
DATA COORDINATING CENTER FOR PERSONAL AIR MONITORING FOR B-WELL-MOM STUDY
B-WELL-MOM 研究个人空气监测数据协调中心
  • 批准号:
    8940709
  • 财政年份:
    2014
  • 资助金额:
    $ 38.1万
  • 项目类别:
ASTHMA PREGNANCY STUDY
哮喘妊娠研究
  • 批准号:
    9332176
  • 财政年份:
    2013
  • 资助金额:
    $ 38.1万
  • 项目类别:

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