权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

DATA COORDINATING CENTER FOR THE PRENATAL AND CHILDHOOD MECHANISMS OF HEALTH DISPARITIES: RECRUITMENT OF THE FIRST SUBCOHORT AND FOLLOW-UP

产前和儿童健康差异机制数据协调中心：第一小组的招募和后续行动

基本信息

批准号：
10576717
负责人：
Seth Sherman
金额：
$ 56.73万
依托单位：
THE EMMES COMPANY, LLC
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-11-01 至 2022-12-15
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10576717
关键词：
18 year old Address Affect Age-Months Beginning of Life Birth COVID-19 COVID-19 pandemic Characteristics Child Development Child Rearing Childhood Clinical Clinical Research Cohort Studies Collaborations Collection Contracts Data Data Collection Data Coordinating Center Data Management Resources Development Discrimination Disease Documentation Economically Deprived Population Eligibility Determination Enrollment Ensure Environment Ethnic Origin Etiology Family First Pregnancy Trimester Generations Gestational Age Health Health behavior Individual Inequality Infant Infant Development Infant Health Intervention Studies Interview Interviewer Knowledge Lead Life Life Cycle Stages Lifting Link Literature Maternal Health Measurement Measures Mediating Medical Records Mental Health Methods Monitor Names National Institute of Child Health and Human Development Neighborhoods Neonatal Observational Study Outcome Parents Participant Patient Recruitments Patient Self-Report Performance Persons Phase Phenotype Play Population Poverty Pregnancy Pregnancy Complications Pregnant Women Procedures Protocols documentation Psychiatric Diagnosis Psychopathology Race Research Research Design Research Personnel Risk Factors Role Sampling Services Ships Site Social support Socioeconomic Status Source Strategic Planning Stressful Event System Testing Training Umbilical Cord Blood United States United States National Institutes of Health Update Woman base biobank childhood adversity clinical research site cohort data quality design ethnic diversity fetal follow up assessment follow-up health disparity improved knowledge base neurodevelopment offspring pandemic disease perceived stress physical conditioning population health prenatal prospective protective factors racial disparity racial diversity recruit social disadvantage socioeconomics substance use theories transmission process

项目摘要

Health disparities in the United States have their origins as early as the prenatal period. Early life conditions including poverty and discrimination generate disparities in health over the life course that become further entrenched in the population through their transmission across generations. Parental mental health, which is strongly linked with social and economic disadvantage as well as child development, may play a key mediating role in the transmission of disparities across generation, but a persistent gap in the disparities literature is that both maternal and paternal psychopathology have not been fully considered as mechanisms nor measured using phenotypically validated approaches. As a result, though disparities in health are well documented, the developmental mechanisms that impact disparities at the very beginning of life are not, particularly those which lead to developmental deficits that emerge long before disease states. The National Institutes of Health (NIH) strategic plan (2016-2020) highlights the need for research to improve “understanding mechanisms that lead to disparities by race/ethnicity and socioeconomic status.” Such enhanced understanding is needed to clarify the etiology of disparities – particularly the specific exposures linked with social or economic disadvantage that impact early development. Advancing knowledge of the developmental mechanisms that generate disparities requires a more thorough understanding of how socioeconomic and race/ethnic status influence the determinants of development from gestation onward. To accomplish this, more in-depth measurement of potential causes of disparities is needed from more diverse samples starting earlier in the life course are needed than is currently available from existing studies.

美国的健康差距早在产前就有了根源。早期生活条件，包括贫穷和歧视，在整个生命过程中造成健康方面的差异，这种差异通过代代相传而进一步加深。父母的心理健康，这是密切相关的社会和经济的劣势，以及儿童的发展，可能会发挥关键的中介作用，在跨代的差异传输，但在差异文献中的一个持续的差距是，母亲和父亲的精神病理学没有被充分考虑的机制，也没有使用表型验证的方法进行测量。因此，尽管健康方面的差异有充分的文献记载，但在生命之初影响差异的发育机制却没有，特别是那些导致发育缺陷的机制，这些缺陷早在疾病状态之前就出现了。美国国立卫生研究院 (NIH)《战略计划》（2016-2020年）强调需要开展研究，以改善“对导致种族/族裔和社会经济地位差异的机制的理解”。需要加强这种了解，以澄清差异的根源，特别是与影响早期发展的社会或经济不利条件有关的具体风险。要进一步了解造成差距的发展机制，就需要更透彻地了解社会经济和种族/族裔地位如何从孕育期起就影响发展的决定因素。要做到这一点，更深入的测量差异的潜在原因是需要从更多样化的样本开始在生命过程中的早期需要比目前可从现有的研究。