ASTHMA PREGNANCY STUDY

哮喘妊娠研究

• 批准号: 9332176
• 负责人: Seth Sherman
• 金额: $ 32.51万
• 依托单位: THE EMMES COMPANY, LLC
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-11 至 2017-08-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9332176
• 关键词: Accounting; Air; Alabama; Asthma; Blood Pressure; Breathing; Cells; Chronic Disease; Clinic; Clinic Visits; Clinical; Clinical Data; Clinical assessments; Cohort Studies; Complication; Data Collection; Discipline of obstetrics; Emergency Situation; Environmental Risk Factor; Epidemiology; Exhalation; Exposure to; Flow Cytometry; Genetic; Hospitalization; Hypersensitivity; Immune; Inflammation; Intake; Literature; Lung Inflammation; Mediation; Medical Records; Minimal Risk Study; National Heart, Lung, and Blood Institute; Nitric Oxide; Patients; Pharmaceutical Preparations; Population; Postpartum Period; Pregnancy; Prevention Research; Procedures; Protocols documentation; Pulmonary Function Test/Forced Expiratory Volume 1; Pulse Oximetry; Questionnaires; Recording of previous events; Recruitment Activity; Regulatory T-Lymphocyte; Reporting; Respiratory physiology; Risk; Risk Factors; Role; Severities; Specimen; Surveys; Symptoms; Universities; Visit; Woman; asthmatic; atopy; base; dietary antioxidant; experience; improved; inflammatory marker; interest; neonatal outcome; pregnancy immunology; prenatal; statistics

The Division of Epidemiology, Statistics and Prevention Research (hereafter, the Division) The B-WELL-Mom clinical centers, Northwestern University and the University of Alabama Birmingham, will recruit a total of 400 asthmatics (200 with well-controlled asthma and 200 with sub-optimal asthma control) and 150 women without asthma from their prenatal clinic populations. Asthma control assessment will be based on the criteria described in the NHLBI expert panel report. Except for asthma history questions, control subjects follow the same protocol. All patients will have four study clinic visits. At each visit, clinical assessments will include blood pressure, pulse oximetry, peak flow, FEV1 and FEV6. Biologic specimens will also be collected. Patients complete questionnaires related to symptoms and risk factors for exacerbation or mediation of asthma or breathing problems. Flow cytometry will be conducted to count immune cells including T-regulatory cells. All of the clinical data collection procedures are well-established procedures with minimal risk and the study surveys are based on preexisting, validated questionnaires. Between clinic visits, women will record their peak flow, exhaled nitric oxide and answer questions on symptoms, medications and other factors that might interfere with breathing. Medical record review will capture emergency visits and hospitalizations as well as details of labor and delivery. Supports Z1AHD008936

流行病学、统计和预防研究处（以下简称该处） 西北大学和亚拉巴马伯明翰大学的B-WELL-Mom临床中心将从产前门诊人群中招募总共400名哮喘患者（200名哮喘控制良好，200名哮喘控制欠佳）和150名无哮喘的妇女。哮喘控制评估将基于NHLBI专家小组报告中描述的标准。除了哮喘史问题，对照组受试者遵循相同的方案。所有患者将接受4次研究诊所访视。每次访视时，临床评估将包括血压、脉搏血氧饱和度、峰流速、FEV 1和FEV 6。还将采集生物标本。患者完成与哮喘或呼吸问题加重或缓解的症状和风险因素相关的问卷调查。将进行流式细胞术以计数免疫细胞，包括调节性T细胞。所有临床数据收集程序均为完善的程序，风险最小，研究调查基于预先存在的经验证的问卷。在诊所就诊之间，女性将记录她们的峰值流量、呼出的一氧化氮，并回答有关症状、药物和其他可能干扰呼吸的因素的问题。医疗记录审查将记录急诊和住院情况以及分娩和分娩的详细信息。支持Z1 AHD 008936