Neuroprotective functions of autophagy regulators in Alzheimer's disease

-淀粉样蛋白的积累在阿尔茨海默病中起核心作用，增强其清除可改善动物阿尔茨海默病模型中的记忆丧失。这个项目建立在我最近发现的细胞清洁系统的调节因子上，“自噬”可以加速细胞中β淀粉样蛋白的去除。本研究将进一步了解自噬调节因子在减轻阿尔茨海默病症状中的保护功能。这项工作的发现可能为开发有效的抗ad治疗方法提供基础。

The accumulation of the beta amyloid protein has a central role in AD and enhancing its removal improves memory loss in animal AD models. This project builds on my recent finding of regulators of a cell housekeeping system, “autophagy” which accelerate removal of beta amyloid in cells. This study will advance knowledge into the protective functions of the autophagy regulators in reducing AD symptoms. Findings from this work might provide the basis for developing effective anti-AD therapeutics.