Identifying the role of emotion processes in core features of Autism Spectrum Disorder
Identifying the role of emotion processes in core features of Autism Spectrum Disorder
批准号:
10001024
负责人:
Vanessa Hus Bal
金额:
$18.23万
依托单位国家:
美国
项目类别:
财政年份:
2017
资助国家:
美国
项目状态:
已结题
起止时间:
2017-09-05 至 2022-08-31
关键词:
12 year oldAffectAffectiveAgeAlzheimer&aposs DiseaseAnimal ModelAreaAutonomic nervous systemBasic ScienceBehaviorBehavioralBiologicalBrainBreathingCaliforniaCardiacChildClinicalClinical ResearchCollectionComplexConsciousDataDepressed moodDevelopmentDiseaseEmotionalEmotional StabilityEmotionsFaceFacial ExpressionFacial MusclesFailureFamiliarityFosteringFoundationsFrontotemporal DementiaFunctional disorderFutureGenerationsGoalsImpairmentIndividualInstructionIntellectual functioning disabilityInterdisciplinary StudyInvestigationKnowledgeLaboratoriesLaboratory FindingLearningLinkLongevityLongitudinal StudiesMaintenanceMajor Depressive DisorderMeasurementMeasuresMediatingMental disordersMentorsMethodologyMethodsMissionMotivationNational Institute of Mental HealthNeurobiologyNeurodevelopmental DisorderNeurologistOutcomePatient Self-ReportPatientsPhysiologicalPopulationProcessPsychiatristPsychiatryPsychologistPsychometricsPsychopathologyPsychophysiologyPublic HealthReactionRegulationResearchRoleSan FranciscoScienceScientistSocial BehaviorSocial FunctioningSocial InteractionStimulusSymptomsSystemTimeTrainingTranslatingUniversitiesVirginiaWithdrawalanimal model developmentautism spectrum disorderautistic childrenbasecareerclinical phenotypeclinical translationcognitive functionemotion dysregulationemotion regulationexperiencegenetic risk factorimprovedinnovationinterestmultidisciplinarymultilevel analysisnew therapeutic targetpatient oriented researchpositive emotional statepreservationprofessorprogramsrelating to nervous systemrespiratoryresponseskillssocialsocial attachmentsocial skillstherapy development
中文摘要
项目摘要/摘要
英文摘要
PROJECT SUMMARY / ABSTRACT
This is a K23 application for Dr. Vanessa H. Bal, an Assistant Professor in Psychiatry at the University of
California San Francisco. Dr. Bal is establishing herself as a clinician-scientist who conducts interdisciplinary,
patient-oriented research aimed at advancing understanding of the biological bases of Autism Spectrum
Disorder (ASD) symptoms. This K23 will provide Dr. Bal with essential support to accomplish the following
goals: 1) develop expertise in the theoretical basis of affective science; 2) gain methodological proficiency
(collection and analysis of psychophysiological and facial behavior data) to conduct future emotion studies in
children with ASD across the range of ability (e.g., minimally verbal); 3) gain familiarity with the neural systems
mediating emotion processes; 4) obtain the knowledge necessary to use laboratory-based findings to
understand mechanisms underlying clinical measures of socioemotional impairments; 5) learn to translate
clinical phenotypes to animal model and treatment development studies; 6) acquire knowledge needed to
conduct longitudinal research with neurodevelopmental populations; and 7) develop an independent
interdisciplinary research career. To achieve these goals, Dr. Bal has assembled a multidisciplinary mentoring
team including a primary mentor: Dr. Howard Rosen (a neurologist with expertise in psychophysiology and the
organization of emotional systems in the brain); four co-mentors: Drs. Virginia Sturm (a neuropsychologist with
expertise in laboratory assessment of emotion and social behavior in patients), Stephen Hinshaw (a
psychologist with expertise in developmental psychopathology and longitudinal studies of neurodevelopmental
disorders), and Matthew State (a psychiatrist and geneticist with expertise in interdisciplinary ASD research);
and a statistical advisor, Dr. Kevin Delucchi (a biostatistician with expertise in psychiatric research).
The proposed project explores the relationship between emotional processes (reactivity and regulation)
and socioemotional dysfunction in ASD. Dr. Bal will use laboratory-based paradigms to measure physiological
(cardiac, respiratory, electrodermal) and behavioral (facial muscles) emotional reactivity and regulation in child-
ren with ASD and typically development (Aims 1 & 2). She will then integrate laboratory findings with clinical
measures of socioemotional functioning and ASD symptoms to determine the real-world impact of emotional
impairments (Aim 3). The goal of Dr. Bal's research is to identify mechanisms underlying socioemotional
impairments that can be used to delineate associations between genetic risk factors and clinical outcomes.
This project is innovative because it explores the potential role of emotion processing in ASD symptoms, using
well-established, translational methods from affective science that have clarified mechanisms underlying
clinical impairments in other patient groups. Results will significantly contribute to our understanding of the
biological basis of ASD symptoms. Dr. Bal's K23 training will prepare her to conduct cutting-edge studies of
aberrant socioemotional development across the lifespan that will inform clinical and basic ASD research.
期刊论文(16)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
DOI:
10.1089/aut.2020.0044
发表时间:
2021-03
期刊:
Autism in adulthood : challenges and management
影响因子:
--
作者:
[Gunin GB, Gravino A, Bal VH]
通讯作者:
Bal VH
DOI:
10.1002/aur.2808
发表时间:
2022-11
期刊:
AUTISM RESEARCH
影响因子:
4.7
作者:
[Jadav, Nikita, Bal, Vanessa H.]
通讯作者:
Bal, Vanessa H.
DOI:
10.1080/13811118.2020.1868367
发表时间:
2022-07
期刊:
ARCHIVES OF SUICIDE RESEARCH
影响因子:
2.8
作者:
[Bal, Vanessa H., Leventhal, Bennett L., Carter, Gregory, Kim, Hosanna, Koh, Yun-Joo, Ha, Mina, Kwon, Ho-Jang, Hong, Patricia, Kim, Young Shin]
通讯作者:
Kim, Young Shin
DOI:
10.1002/aur.2480
发表时间:
2021-06
期刊:
Autism research : official journal of the International Society for Autism Research
影响因子:
--
作者:
[Bal VH, Wilkinson E, White LC, Law JK, SPARK Consortium, Feliciano P, Chung WK]
通讯作者:
Chung WK
Measurement of subcategories of repetitive behaviors in autistic adolescents and adults.
自闭症青少年和成人重复行为子类别的测量。
DOI:
10.1089/aut.2019.0056
发表时间:
2020
期刊:
Autism in adulthood : challenges and management
影响因子:
--
作者:
[McDermott,CourtneyR, Farmer,Cristan, Gotham,KatherineO, Bal,VanessaH]
通讯作者:
Bal,VanessaH
共 8 条
海外基金