rTMS in alleviating Pain and Co-morbid symptoms in GWVI
rTMS 缓解 GWVI 的疼痛和共病症状
基本信息
- 批准号:10041709
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-10-01 至 2024-09-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAdoptedAnalgesicsAnesthesia proceduresAntidepressive AgentsArthralgiaAwardBrainBrain regionChronic HeadachesClinicalClinical TrialsContralateralDevelopmentDiagnosisDiffuseEtiologyEvaluationFDA approvedFunctional disorderFundingGulf WarGulf War veteranHamilton Rating Scale for DepressionHeadacheInvestigationLeftLocationMagnetic Resonance ImagingMaintenanceMajor Depressive DisorderMental DepressionMeta-AnalysisMigraineMilitary PersonnelMotor CortexMulti-Institutional Clinical TrialMyalgiaNarcoticsNeuronavigationNeuropsychologyPainPain managementPainlessPatientsPersian GulfPersian Gulf SyndromePharmacological TreatmentPhasePrefrontal CortexPrevalencePreventionPsychophysiologic DisordersQuality of lifeRandomizedResearchSeveritiesSiteSpecificitySymptomsSystemTranscranial magnetic stimulationTreatment EfficacyTreatment ProtocolsVeteransaffective disturbanceassociated symptomchronic painchronic pain patientchronic painful conditioncomorbiditydepressive symptomsdesigndisabling symptomefficacy evaluationimprovedinnovationmild traumatic brain injurymilitary veteranpain reliefpain symptompainful neuropathyphysical symptomrandomized controlled studyrehabilitation strategyrepetitive transcranial magnetic stimulationsham-controlled studyside effecttreatment effecttreatment strategy
项目摘要
Abstract
Headaches (HA), muscle and joint pain and depression are some of the most common
debilitating symptoms in military personnel served in the 1990-1991 Persian Gulf War (GW1).
Migraine like HA and diffuse body pain were detected in 64% of Gulf War Veteran (GWV)
diagnosed with Gulf War Veterans’ Illnesses (GWVI). Likewise, depression carries a very high co-
morbid prevalence (50%) in patients with chronic pain, and in GWV with GWVI related chronic
HA, and body muscle and joint pain conditions (GWVI-HAP). Repetitive transcranial magnetic
stimulation (rTMS) offers an effective non-invasive treatment option for GWVI-HAP. Our
preliminary study funded by the DOD Innovation Treatment Evaluation Award for GWVI
demonstrated that a short course (4 sessions) of rTMS at the motor cortex could significantly
reduce GWI-HAP symptoms up to two months. This multi-center clinical trial study aims to further:
1) valid the long-term efficacy of the treatment for GWI-HAP and depression; and 2) assess site
specificity of the treatment for both pain and depression.
!
摘要
头痛(HA),肌肉和关节疼痛和抑郁症是一些最常见的
在1990-1991年波斯湾战争(GW 1)中服役的军事人员的衰弱症状。
64%的海湾战争退伍军人(GWV)有偏头痛样HA和弥漫性躯体疼痛
海湾战争退伍军人疾病(GWVI)同样,抑郁症也会带来很高的并发症,
慢性疼痛患者和GWV伴GWVI相关慢性疼痛患者的发病率(50%)
HA以及身体肌肉和关节疼痛状况(GWVI-HAP)。重复经颅磁
经颅磁刺激(rTMS)为GWVI-HAP提供了一种有效的非侵入性治疗选择。我们
由国防部创新治疗评估奖资助的GWVI初步研究
证明在运动皮层进行短期(4次)rTMS可以显著地
减少GWI-HAP症状长达两个月。本多中心临床试验研究旨在进一步:
1)有效的治疗GWI-HAP和抑郁症的长期疗效; 2)评估部位
治疗疼痛和抑郁症的特异性。
!
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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DAVID J. CLARK其他文献
DAVID J. CLARK的其他文献
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{{ truncateString('DAVID J. CLARK', 18)}}的其他基金
rTMS in alleviating Pain and Co-morbid symptoms in GWVI
rTMS 缓解 GWVI 的疼痛和共病症状
- 批准号:
10295159 - 财政年份:2019
- 资助金额:
-- - 项目类别:
rTMS in alleviating Pain and Co-morbid symptoms in GWVI
rTMS 缓解 GWVI 的疼痛和共病症状
- 批准号:
10578659 - 财政年份:2019
- 资助金额:
-- - 项目类别:
Traumatic Brain Injury and Endogenous Pain Modulation
创伤性脑损伤和内源性疼痛调节
- 批准号:
10329882 - 财政年份:2016
- 资助金额:
-- - 项目类别:
Pain after Trauma and TBI: Epigenetic Mechanisms
创伤和创伤性脑损伤后的疼痛:表观遗传机制
- 批准号:
9215534 - 财政年份:2016
- 资助金额:
-- - 项目类别:
Neural immunoregulation of post-traumatic autoimmunity
创伤后自身免疫的神经免疫调节
- 批准号:
10522859 - 财政年份:2016
- 资助金额:
-- - 项目类别:
Pain after Trauma and TBI: Epigenetic Mechanisms
创伤和创伤性脑损伤后的疼痛:表观遗传机制
- 批准号:
9076504 - 财政年份:2016
- 资助金额:
-- - 项目类别:
Neural Immunoregulation of Post-Traumatic Autoimmunity
创伤后自身免疫的神经免疫调节
- 批准号:
9765423 - 财政年份:2016
- 资助金额:
-- - 项目类别:
Neural Immunoregulation of Post-Traumatic Autoimmunity
创伤后自身免疫的神经免疫调节
- 批准号:
9172811 - 财政年份:2016
- 资助金额:
-- - 项目类别:
Traumatic Brain Injury and Endogenous Pain Modulation
创伤性脑损伤和内源性疼痛调节
- 批准号:
10552600 - 财政年份:2016
- 资助金额:
-- - 项目类别:
Neural immunoregulation of post-traumatic autoimmunity
创伤后自身免疫的神经免疫调节
- 批准号:
10698029 - 财政年份:2016
- 资助金额:
-- - 项目类别:
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