rTMS in alleviating Pain and Co-morbid symptoms in GWVI

rTMS 缓解 GWVI 的疼痛和共病症状

• 批准号: 10578659
• 负责人: DAVID J. CLARK
• 金额: --
• 依托单位: VA SAN DIEGO HEALTHCARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-10-01 至 2025-09-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10578659
• 关键词: Address; Adopted; Analgesics; Anesthesia procedures; Antidepressive Agents; Arthralgia; Award; Brain region; Chronic Headaches; Clinical; Clinical Trials; Contralateral; Development; Diagnosis; Diffuse; Etiology; Evaluation; FDA approved; Functional disorder; Funding; Gulf War; Gulf War veteran; Hamilton Rating Scale for Depression; Headache; Investigation; Left; Location; Maintenance; Major Depressive Disorder; Mental Depression; Meta-Analysis; Migraine; Military Personnel; Motor Cortex; Multi-Institutional Clinical Trial; Myalgia; Narcotics; Neuroanatomy; Neuronavigation; Neuropsychology; Pain; Pain management; Painless; Patients; Persian Gulf; Persian Gulf Syndrome; Pharmacological Treatment; Phase; Prefrontal Cortex; Prevalence; Prevention; Psychophysiologic Disorders; Quality of life; Randomized; Research; Severities; Site; Specificity; Symptoms; System; Transcranial magnetic stimulation; Treatment Efficacy; Treatment Protocols; Veterans; affective disturbance; associated symptom; brain magnetic resonance imaging; chronic pain; chronic pain patient; chronic painful condition; comorbidity; depressive symptoms; design; disabling symptom; efficacy evaluation; improved; innovation; mild traumatic brain injury; military veteran; pain relief; pain symptom; painful neuropathy; physical symptom; randomized, controlled study; rehabilitation strategy; repetitive transcranial magnetic stimulation; sham-controlled study; side effect; treatment effect; treatment strategy

Abstract Headaches (HA), muscle and joint pain and depression are some of the most common debilitating symptoms in military personnel served in the 1990-1991 Persian Gulf War (GW1). Migraine like HA and diffuse body pain were detected in 64% of Gulf War Veteran (GWV) diagnosed with Gulf War Veterans’ Illnesses (GWVI). Likewise, depression carries a very high co- morbid prevalence (50%) in patients with chronic pain, and in GWV with GWVI related chronic HA, and body muscle and joint pain conditions (GWVI-HAP). Repetitive transcranial magnetic stimulation (rTMS) offers an effective non-invasive treatment option for GWVI-HAP. Our preliminary study funded by the DOD Innovation Treatment Evaluation Award for GWVI demonstrated that a short course (4 sessions) of rTMS at the motor cortex could significantly reduce GWI-HAP symptoms up to two months. This multi-center clinical trial study aims to further: 1) valid the long-term efficacy of the treatment for GWI-HAP and depression; and 2) assess site specificity of the treatment for both pain and depression. !

摘要 头痛（HA），肌肉和关节疼痛和抑郁症是一些最常见的 在1990-1991年波斯湾战争（GW 1）中服役的军事人员的衰弱症状。 64%的海湾战争退伍军人（GWV）有偏头痛样HA和弥漫性躯体疼痛 海湾战争退伍军人疾病（GWVI）同样，抑郁症也会带来很高的并发症， 慢性疼痛患者和GWV伴GWVI相关慢性疼痛患者的发病率（50%） HA和身体肌肉和关节疼痛状况（GWVI-HAP）。重复经颅磁 经颅磁刺激（rTMS）为GWVI-HAP提供了一种有效的非侵入性治疗选择。我们 由国防部创新治疗评估奖资助的GWVI初步研究 证明在运动皮层进行短期（4次）rTMS可以显著地 减少GWI-HAP症状长达两个月。本多中心临床试验研究旨在进一步： 1)有效的治疗GWI-HAP和抑郁症的长期疗效; 2）评估部位 治疗疼痛和抑郁症的特异性。 !