The iâ¥Rhythm Project: Healthy sleep and behavioral rhythms for obesity prevention

项目概要/摘要 美国夏季儿童标准化BMI（BMIz）增加， 化国际大证明这一点的最大研究是我们的5年纵向研究（幼儿园-5年级） 这表明，从小学早期开始，孩子们开始一个一致的模式， 学年期间BMIz的改善和夏季BMIz的显著增加， 夏季BMIz增加导致5年级超重或肥胖的风险增加。 睡眠时间缩短和昼夜节律紊乱已明确与肥胖发病有关。 具体来说，睡眠和饮食模式的日常行为节奏的变化与增加的 肥胖，通过随后的分子生物钟改变介导。的过渡 学年到暑假代表了一段时间，在这段时间里，孩子们可能会经历他们的生活的变化。 行为节律（即，睡眠和行为节律）。人际社会节律疗法（IPSRT）是一种 双相情感障碍的循证治疗，已证明有效防止复发 情绪障碍，通过促进预防内源性昼夜节律失调， 稳定的行为节律（例如，睡眠和饮食模式）。本研究的目的是：1）适应 IPSRT在暑假期间促进儿童稳定的行为节律，以预防夏季 BMIz的增加（即，（二）进行试验研究以探讨有关计划的可行性， 可接受性和初步疗效的间歇性节律项目，以防止增加儿童的BMIz期间 夏天将利用移动医疗技术，以达到父母使用熟悉和方便 资源在校外时间。K99阶段将提供额外的培训， 睡眠和昼夜节律研究以及行为健康干预措施开发方面的专业知识 使用移动医疗技术，以及解决以下问题所需的额外专业和研究发展： 培训的差距。额外的培训将有助于过渡到以发展为重点的职业生涯， 行为干预，以解决睡眠和昼夜节律在儿童肥胖症发病中的作用。 拟议的研究解决了科学知识和实践中的几个差距：1）缺乏 针对儿童夏季体重增加的干预措施2）在以下方面的知识存在重大差距： 睡眠和昼夜节律在预防儿童肥胖中的作用; 3）解决夏季体重问题 gain为解决预防儿童肥胖问题提供了一个重要机会。这种创新的应用 代表了一种新的干预应用，具有促进稳定行为节律的既定功效 用于治疗双相情感障碍，并有望同样用于预防儿童肥胖。本研究 是第一个解决睡眠和昼夜节律在预防儿童肥胖中的作用， 这种干预措施对长期预防肥胖的初步证据。

PROJECT SUMMARY/ABSTRACT Increases in children's standardized BMI (BMIz) have been demonstrated during summer across the US and internationally. The largest study to demonstrate this was our 5-year longitudinal study (kindergarten – 5th grade) which demonstrated that beginning in early elementary school, children begin a consistent pattern of improvements in BMIz during the school year and significant increases in BMIz during summer, with summertime increases in BMIz contributing to increased risk of becoming overweight or obese by 5th grade. Shortened sleep duration and circadian rhythm disturbances have been clearly implicated in obesity onset. Specifically, shifts in the daily behavioral rhythms of sleep and meal patterns are associated with increased adiposity, mediated through subsequent alterations in the molecular circadian clock. The transition from the school year to summer vacation represents a time during which children may experience changes in their behavioral rhythms (i.e., sleep and behavioral rhythms). Interpersonal Social Rhythm Therapy (IPSRT) is an evidence based treatment for bipolar disorder that has demonstrated efficacy to prevent the reoccurrences of mood disturbances by preventing the misalignment of endogenous circadian rhythms through the promotion of stable behavioral rhythms (e.g., sleep and meal patterns). The goals of the proposed research are to 1) adapt IPSRT to promote stable behavioral rhythms in children during summer vacation for the prevention of summer increases in BMIz (i.e., the i♥rhythm project) and 2) conduct a pilot study to examine the feasibility, acceptability, and preliminary efficacy of the i♥rhythm project to prevent increases in children's BMIz during summer. mHealth technologies will be utilized in order to reach parents using a familiar and convenient resource during out of school times. The K99 phase will provide additional training in order to develop expertise in sleep and circadian rhythms research and the development of behavioral health interventions using mHealth technologies, as well as additional professional and research development needed to address gaps in training. The additional training will facilitate transition to a career focused on the development of behavioral interventions to address the role of sleep and circadian rhythms in the onset of childhood obesity. The proposed research addresses several gaps in scientific knowledge and practice: 1) there are a paucity of interventions addressing summer weight gain in children 2) there is a significant gap in knowledge regarding the role of sleep and circadian rhythms in the prevention of child obesity and 3) addressing summer weight gain provides an important opportunity to address the prevention of child obesity. This innovative application represents a novel application of an intervention with established efficacy to promote stable behavioral rhythms for treatment of bipolar disorder and promises to do the same for the prevention of child obesity. This research is the first to address the role of sleep and circadian rhythms in the prevention of child obesity and to examine the preliminary evidence of such an intervention on the long-term prevention of obesity.