权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

The iâ¥Rhythm Project: Healthy sleep and behavioral rhythms for obesity prevention

iàRhythm 项目：预防肥胖的健康睡眠和行为节律

基本信息

批准号：
10218226
负责人：
Jennette P Moreno
金额：
$ 23.17万
依托单位：
BAYLOR COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-26 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10218226
关键词：
8 year old Address Age Behavior Therapy Behavioral Bipolar Disorder Body mass index Child Child Rearing Circadian Rhythms Climate Development Evidence based treatment Family Feasibility Studies Geographic Locations Goals Household and Family International Intervention Japan Knowledge Longitudinal Studies Manic Mediating Minnesota Molecular Monitor Obesity Obesity Epidemic Overweight Parents Participant Pattern Peripheral Phase Physical activity Pilot Projects Prevention Research Resources Risk Risk Factors Role Sampling School-Age Population Schools Sleep Sleep Wake Cycle Sleep disturbances Standardization Structure Students Subgroup Technology Television Temperature Texas Time Training Variant Weather Weight Gain Wyoming affective disturbance behavioral health intervention career circadian pacemaker depressive symptoms elementary school ethnic diversity excessive weight gain experience family structure fifth grade innovation kindergarten mHealth novel obesity in children obesity prevention obesity risk prevent research and development second grade sleep behavior sleep pattern social suprachiasmatic nucleus

项目摘要

PROJECT SUMMARY/ABSTRACT Increases in children's standardized BMI (BMIz) have been demonstrated during summer across the US and internationally. The largest study to demonstrate this was our 5-year longitudinal study (kindergarten – 5th grade) which demonstrated that beginning in early elementary school, children begin a consistent pattern of improvements in BMIz during the school year and significant increases in BMIz during summer, with summertime increases in BMIz contributing to increased risk of becoming overweight or obese by 5th grade. Shortened sleep duration and circadian rhythm disturbances have been clearly implicated in obesity onset. Specifically, shifts in the daily behavioral rhythms of sleep and meal patterns are associated with increased adiposity, mediated through subsequent alterations in the molecular circadian clock. The transition from the school year to summer vacation represents a time during which children may experience changes in their behavioral rhythms (i.e., sleep and behavioral rhythms). Interpersonal Social Rhythm Therapy (IPSRT) is an evidence based treatment for bipolar disorder that has demonstrated efficacy to prevent the reoccurrences of mood disturbances by preventing the misalignment of endogenous circadian rhythms through the promotion of stable behavioral rhythms (e.g., sleep and meal patterns). The goals of the proposed research are to 1) adapt IPSRT to promote stable behavioral rhythms in children during summer vacation for the prevention of summer increases in BMIz (i.e., the i♥rhythm project) and 2) conduct a pilot study to examine the feasibility, acceptability, and preliminary efficacy of the i♥rhythm project to prevent increases in children's BMIz during summer. mHealth technologies will be utilized in order to reach parents using a familiar and convenient resource during out of school times. The K99 phase will provide additional training in order to develop expertise in sleep and circadian rhythms research and the development of behavioral health interventions using mHealth technologies, as well as additional professional and research development needed to address gaps in training. The additional training will facilitate transition to a career focused on the development of behavioral interventions to address the role of sleep and circadian rhythms in the onset of childhood obesity. The proposed research addresses several gaps in scientific knowledge and practice: 1) there are a paucity of interventions addressing summer weight gain in children 2) there is a significant gap in knowledge regarding the role of sleep and circadian rhythms in the prevention of child obesity and 3) addressing summer weight gain provides an important opportunity to address the prevention of child obesity. This innovative application represents a novel application of an intervention with established efficacy to promote stable behavioral rhythms for treatment of bipolar disorder and promises to do the same for the prevention of child obesity. This research is the first to address the role of sleep and circadian rhythms in the prevention of child obesity and to examine the preliminary evidence of such an intervention on the long-term prevention of obesity.

项目概要/摘要夏季期间，美国各地儿童的标准化体重指数 (BMIz) 有所增加，国际上。证明这一点的最大规模的研究是我们为期 5 年的纵向研究（幼儿园 – 第五年级）这表明，从小学早期开始，孩子们就开始了一致的模式学年期间 BMIz 有所改善，夏季期间 BMIz 显着增加，其中夏季体重指数的增加导致五年级时超重或肥胖的风险增加。睡眠时间缩短和昼夜节律紊乱显然与肥胖的发生有关。具体来说，睡眠和膳食模式的日常行为节奏的变化与增加肥胖是通过分子生物钟的后续改变介导的。过渡从学年到暑假是孩子们可能经历变化的时期行为节律（即睡眠和行为节律）。人际社会节律疗法（IPSRT）是一种双相情感障碍的循证治疗已被证明可以有效预防双相情感障碍的再次发生通过促进内源性昼夜节律的失调来预防情绪障碍稳定的行为节律（例如睡眠和进餐模式）。拟议研究的目标是 1）适应 IPSRT促进暑假期间儿童稳定行为节律预防暑 BMIz 的增加（即 i♥节奏项目）以及 2) 进行试点研究以检验可行性， i♥rhythm 项目在预防儿童 BMIz 增加方面的可接受性和初步效果夏天。将利用移动医疗技术，以便通过熟悉且方便的方式联系家长放学期间的资源。 K99阶段将提供额外的培训，以发展睡眠和昼夜节律研究以及行为健康干预措施开发方面的专业知识使用移动医疗技术，以及解决这一问题所需的额外专业和研究开发培训方面的差距。额外的培训将有助于过渡到专注于发展的职业行为干预，以解决睡眠和昼夜节律在儿童肥胖发病中的作用。拟议的研究解决了科学知识和实践中的几个差距：1）缺乏解决儿童夏季体重增加问题的干预措施 2) 在这方面的知识存在显着差距睡眠和昼夜节律在预防儿童肥胖中的作用以及 3) 解决夏季体重问题增益为预防儿童肥胖提供了重要机会。这个创新的应用代表了干预措施的一种新颖应用，具有促进稳定行为节律的功效用于治疗双相情感障碍，并承诺为预防儿童肥胖采取同样的措施。这项研究是第一个解决睡眠和昼夜节律在预防儿童肥胖中的作用并检查这种干预措施长期预防肥胖的初步证据。

项目成果

期刊论文数量（13）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Validation of the Family Health Behavior Scale for the Brazilian population.

对巴西人口的家庭健康行为量表的验证。

DOI：
10.1016/j.jped.2021.04.002
发表时间：
2022-01
期刊：
JORNAL DE PEDIATRIA
影响因子：
3.3
作者：
Preto, Luiza Tweedie;Scarpatto, Camila H.;Gaudie Ley, Laura Lessa;Silveira, Carolina;Salerno, Margareth Rodrigues;Moreno, Jennette Palcic;de Jezus Castro, Stela Maris;Booij, Linda;Mattiello, Rita
通讯作者：
Mattiello, Rita

Evaluation of a Circadian Rhythm and Sleep-Focused Mobile Health Intervention for the Prevention of Accelerated Summer Weight Gain Among Elementary School-Age Children: Protocol for a Randomized Controlled Feasibility Study.

DOI：
10.2196/37002
发表时间：
2022-05-16
期刊：
JMIR RESEARCH PROTOCOLS
影响因子：
1.7
作者：
Moreno, Jennette P.;Dadabhoy, Hafza;Musaad, Salma;Baranowski, Tom;Thompson, Debbe;Alfano, Candice A.;Crowley, Stephanie J.
通讯作者：
Crowley, Stephanie J.

The roles of sleep and eating patterns in adiposity gain among preschool-aged children.

睡眠和饮食模式在学龄前儿童肥胖中的作用。

DOI：
10.1093/ajcn/nqac197
发表时间：
2022
期刊：
The American journal of clinical nutrition
影响因子：
0
作者：
Goetz,AmyR;Jindal,Ishita;Moreno,JennetteP;Puyau,MauriceR;Adolph,AnneL;Musaad,Salma;Butte,NancyF;Bacha,Fida
通讯作者：
Bacha,Fida

School-Based Weight Management Program Curbs Summer Weight Gain Among Low-Income Hispanic Middle School Students.

学校体重管理计划抑制低收入西班牙裔中学生夏季体重增加。