The i♥Rhythm Project: Healthy sleep and behavioral rhythms for obesity prevention

iâ¥节奏项目：预防肥胖的健康睡眠和行为节奏

• 批准号: 9988577
• 负责人: Jennette P Moreno
• 金额: $ 24.9万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-26 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9988577
• 关键词: Rhythm; Project; Healthy; sleep; behavioral

PROJECT SUMMARY/ABSTRACT Increases in children's standardized BMI (BMIz) have been demonstrated during summer across the US and internationally. The largest study to demonstrate this was our 5-year longitudinal study (kindergarten – 5th grade) which demonstrated that beginning in early elementary school, children begin a consistent pattern of improvements in BMIz during the school year and significant increases in BMIz during summer, with summertime increases in BMIz contributing to increased risk of becoming overweight or obese by 5th grade. Shortened sleep duration and circadian rhythm disturbances have been clearly implicated in obesity onset. Specifically, shifts in the daily behavioral rhythms of sleep and meal patterns are associated with increased adiposity, mediated through subsequent alterations in the molecular circadian clock. The transition from the school year to summer vacation represents a time during which children may experience changes in their behavioral rhythms (i.e., sleep and behavioral rhythms). Interpersonal Social Rhythm Therapy (IPSRT) is an evidence based treatment for bipolar disorder that has demonstrated efficacy to prevent the reoccurrences of mood disturbances by preventing the misalignment of endogenous circadian rhythms through the promotion of stable behavioral rhythms (e.g., sleep and meal patterns). The goals of the proposed research are to 1) adapt IPSRT to promote stable behavioral rhythms in children during summer vacation for the prevention of summer increases in BMIz (i.e., the i♥rhythm project) and 2) conduct a pilot study to examine the feasibility, acceptability, and preliminary efficacy of the i♥rhythm project to prevent increases in children's BMIz during summer. mHealth technologies will be utilized in order to reach parents using a familiar and convenient resource during out of school times. The K99 phase will provide additional training in order to develop expertise in sleep and circadian rhythms research and the development of behavioral health interventions using mHealth technologies, as well as additional professional and research development needed to address gaps in training. The additional training will facilitate transition to a career focused on the development of behavioral interventions to address the role of sleep and circadian rhythms in the onset of childhood obesity. The proposed research addresses several gaps in scientific knowledge and practice: 1) there are a paucity of interventions addressing summer weight gain in children 2) there is a significant gap in knowledge regarding the role of sleep and circadian rhythms in the prevention of child obesity and 3) addressing summer weight gain provides an important opportunity to address the prevention of child obesity. This innovative application represents a novel application of an intervention with established efficacy to promote stable behavioral rhythms for treatment of bipolar disorder and promises to do the same for the prevention of child obesity. This research is the first to address the role of sleep and circadian rhythms in the prevention of child obesity and to examine the preliminary evidence of such an intervention on the long-term prevention of obesity.

项目概要/摘要 夏季期间，美国各地儿童的标准化体重指数 (BMIz) 有所增加， 国际上。证明这一点的最大规模的研究是我们为期 5 年的纵向研究（幼儿园 – 第五 年级）这表明，从小学早期开始，孩子们就开始了一致的模式 学年期间 BMIz 有所改善，夏季期间 BMIz 显着增加，其中 夏季体重指数的增加导致五年级时超重或肥胖的风险增加。 睡眠时间缩短和昼夜节律紊乱显然与肥胖的发生有关。 具体来说，睡眠和膳食模式的日常行为节奏的变化与增加 肥胖是通过分子生物钟的后续改变介导的。过渡从 学年到暑假是孩子们可能经历变化的时期 行为节律（即睡眠和行为节律）。人际社会节律疗法（IPSRT）是一种 双相情感障碍的循证治疗已被证明可以有效预防双相情感障碍的再次发生 通过促进内源性昼夜节律的失调来预防情绪障碍 稳定的行为节律（例如睡眠和进餐模式）。拟议研究的目标是 1）适应 IPSRT促进暑假期间儿童稳定行为节律预防暑 BMIz 的增加（即 i♥节奏项目）以及 2) 进行试点研究以检验可行性， i♥rhythm 项目在预防儿童 BMIz 增加方面的可接受性和初步效果 夏天。将利用移动医疗技术，以便通过熟悉且方便的方式联系家长 放学期间的资源。 K99阶段将提供额外的培训，以发展 睡眠和昼夜节律研究以及行为健康干预措施开发方面的专业知识 使用移动医疗技术，以及解决这一问题所需的额外专业和研究开发 培训方面的差距。额外的培训将有助于过渡到专注于发展的职业 行为干预，以解决睡眠和昼夜节律在儿童肥胖发病中的作用。 拟议的研究解决了科学知识和实践中的几个差距：1）缺乏 解决儿童夏季体重增加问题的干预措施 2) 在这方面的知识存在显着差距 睡眠和昼夜节律在预防儿童肥胖中的作用以及 3) 解决夏季体重问题 增益为预防儿童肥胖提供了重要机会。这个创新的应用 代表了干预措施的一种新颖应用，具有促进稳定行为节律的功效 用于治疗双相情感障碍，并承诺为预防儿童肥胖采取同样的措施。这项研究 是第一个解决睡眠和昼夜节律在预防儿童肥胖中的作用并检查 这种干预措施长期预防肥胖的初步证据。