Enrichment and Research Administration Core

浓缩和研究管理核心

• 批准号: 10001760
• 负责人: DEAN R MADDEN
• 金额: $ 21.04万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10001760
• 关键词: Achievement; Address; Advisory Committees; Ally; Applications Grants; Area; Award; Basic Science; Biology; Biomedical Research; Clinical; Collaborations; Communication; Communities; Core Facility; Cystic Fibrosis; Data; Decision Making; Doctor of Philosophy; Education; Educational Activities; Educational workshop; Electronic Mail; Ensure; Environment; Epithelial; Epithelium; Expenditure; Extramural Activities; Faculty; Faculty Recruitment; Feedback; Fostering; Foundations; Funding; Goals; Health; Immune response; Immunity; Individual; Infrastructure; Intellectual Property; Interdisciplinary Study; Laboratories; Leadership; Mission; Monitor; National Institute of Diabetes and Digestive and Kidney Diseases; Outcome; Patient-Focused Outcomes; Performance; Pilot Projects; Probability; Process; Productivity; Program Development; Progress Reports; Reporting; Research; Research Activity; Research Personnel; Research Project Grants; Research Support; Research Technics; Resources; Role; Schedule; Series; Services; Structure; Technology Transfer; Therapeutic; Time; Training Activity; Translating; Translational Research; Translations; United States National Institutes of Health; Validation; conflict resolution; cystic fibrosis patients; dysbiosis; experience; flexibility; forging; gastrointestinal; high standard; improved; innovation; interest; liver function; meetings; member; microbial colonization; microbial community; novel therapeutic intervention; peer; programs; quality assurance; ranpirnase; recruit; research and development; skills; social media; success; symposium; translational pipeline; web site

The overarching goal of the Enrichment & Research Administration Core (ERAC) is to support the scientific mission of the Dartmouth Cystic Fibrosis Research Center (DartCF): to foster a superior environment for discovery of new principles of CF biology, epithelial function, microbial colonization, and host responses, and their translation into clinical outcomes, in areas of interest to NIDDK. Launched in 2018, DartCF will continue to support three Biomedical Research Cores. It will expand its pilot program to recruit new investigators and fund new research directions, including CF gut dysbiosis, GI microbial communities, and liver function. It will also support an intensive research development program and will leverage institutional resources for program enrichment, including annual symposia and new training modules in best research practices. Working across the basic and translational spectrum, these components will advance the identification and validation of new therapeutic strategies in CF. Scientific leadership will be provided by Director Dean Madden, PhD, the DartCF leadership team, Internal and External Advisory Committees, and an inclusive Faculty Council. The role of the ERAC is to provide efficient scientific leadership, organizational support, and fiscal oversight for all Center components. Building on strategies developed for other programmatic awards and deployed in year one of funding, the ERAC will achieve the following Specific Aims: (1) To provide scientific leadership supporting all DartCF members as they explore new high-impact research directions; (2) To support strategic research development opportunities; (3) To facilitate robust scientific communication; (4) To offer streamlined administrative and fiscal support, providing timely and accurate reporting to DartCF and institutional leadership and NIDDK Program staff; and (5) To enrich the scientific and research environment by deploying institutional resources. Each of these aims will advance the DartCF mission. Inclusive, experienced leadership will identify and create new opportunities for Center faculty to pursue basic and translational research projects in CF, with a goal of improving therapeutic options and patient outcomes. The education program will provide expert guidance to our faculty, enhancing their research productivity and generating additional extramural support for CF research. A weekly research-in-progress series, interspersed with invited seminars and an annual Dartmouth CF Retreat, will sustain a highly integrated, interactive scientific community and stimulate the exploration of new research directions. Together with the Biomedical Research Cores, pilot and core funding will both recruit faculty to the Center and increase their ability to compete for extramural funding. Program leadership has a strong track record of scientific collaboration and two decades' experience with multiproject awards. Leveraging these skillsets, we have developed an Administrative Core committed to providing excellent organizational support to the investigators of DartCF and to advancing its success as an NIDDK-supported CF Research Center.

浓缩和研究管理核心（ERAC）的首要目标是支持科学研究， 达特茅斯囊性纤维化研究中心（DartCF）的使命：为以下患者营造上级环境： 发现CF生物学、上皮功能、微生物定植和宿主反应的新原理，以及 在NIDDK感兴趣的领域，将其转化为临床结果。DartCF于2018年推出，将继续 支持三个生物医学研究核心。它将扩大其试点计划，招募新的调查人员， 新的研究方向，包括CF肠道生态失调，GI微生物群落和肝功能。它还将 支持密集研究开发计划，并将利用机构资源进行规划 丰富，包括年度专题讨论会和最佳研究做法的新培训单元。跨越 基本和平移光谱，这些组件将推进新的识别和验证 CF的治疗策略DartCF主任Dean Madden博士将提供科学领导 领导团队，内部和外部咨询委员会，以及包容性的学院理事会。的作用 ERAC将为所有中心提供有效的科学领导、组织支持和财政监督。 件.在为其他方案奖制定并在2009年第一年部署的战略的基础上， ERAC将实现以下具体目标：（1）提供科学领导，支持所有 DartCF成员，因为他们探索新的高影响力的研究方向;（2）支持战略研究 （3）促进科学交流;（4）提供简化的 行政和财政支持，向DartCF和机构领导提供及时准确的报告 和NIDDK计划的工作人员;和（5）通过部署机构， 资源这些目标中的每一个都将推进DartCF的使命。具有包容性和经验丰富的领导层将确定 并为中心教师创造新的机会，在CF进行基础和转化研究项目， 改善治疗选择和患者结局的目标。教育计划将提供专家 指导我们的教师，提高他们的研究生产力，并产生额外的校外支持， CF研究。每周一次的研究进展系列，穿插邀请研讨会和年度达特茅斯 CF务虚会，将维持一个高度整合，互动的科学界，并刺激新的探索 研究方向。连同生物医学研究核心，试点和核心资金都将招募教师 并提高他们竞争校外资金的能力。项目领导力有很强的追踪能力 科学合作的记录和二十年的多项目获奖经验。利用这些 技能，我们已经制定了一个行政核心，致力于提供出色的组织支持， DartCF的研究人员，并推动其作为NIDDK支持的CF研究中心的成功。