DartCF: The Dartmouth Cystic Fibrosis Research Center
DartCF:达特茅斯囊性纤维化研究中心
基本信息
- 批准号:10895148
- 负责人:
- 金额:$ 4.22万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-07-01 至 2025-06-30
- 项目状态:未结题
- 来源:
- 关键词:AccelerationAddressAffectAntibioticsArchivesAreaAwardBasic ScienceBioinformaticsBiologyBiostatistics CoreCessation of lifeChronicClinicalClinical ResearchCoculture TechniquesCollaborationsCommunitiesComplexCoupledCystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorDataData ScienceData SetDatabasesDevelopmentDiabetes MellitusDiseaseEcologyEducational workshopEndowmentEpitheliumEvaluationExtramural ActivitiesFacultyFosteringFoundationsFunctional disorderFundingGenetic DiseasesGoalsImmuneImmune responseImmunityInflammatory ResponseInstitutionInterventionInvestigationLiver diseasesLongevityLungMalnutritionMediatingMetabolicMicrobeMiningMissionModelingMonitorMutationNational Institute of Diabetes and Digestive and Kidney DiseasesOrganOutcomePancreatitisPathogenesisPatientsPharmaceutical PreparationsPilot ProjectsPreclinical Drug DevelopmentQuality of lifeResearchResearch PersonnelResourcesRespiratory Tract InfectionsServicesSignal TransductionStructureSymptomsSystemTherapeuticTissuesTrainingTranslational ResearchVirulenceWorkantimicrobialbasebody systemcareer developmentcohortcommensal microbescommunity centercomplex datacystic fibrosis patientscystic fibrosis related diabetesdata submissiondysbiosisforginggastrointestinalgut dysbiosisgut microbeshost-microbe interactionsimprovedimproved outcomeinnovationinsightinterestinteroperabilitymembermicrobialmicrobial communitymicrobiomenovelnovel strategiesnovel therapeutic interventionnovel therapeuticsopen datapathogenic microbepre-clinicalprematureprogramsrecruitsynergismsystemic inflammatory responsetooltranslational study
项目摘要
In cystic fibrosis (CF), mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) unleash a
cascade of clinical disorders, including chronic airway infections, systemic inflammation, microbial virulence,
diabetes, malnutrition and liver disease. Great progress has been made in some areas of disease, and CFTR
modulators provide dramatic benefits to some patients. Still, there is growing evidence of the interconnections
among lung and gut dysbiosis and CF pathogenesis. As patients live longer, formerly rare symptoms are
becoming more common. Thus, there is a pressing need to both understand and systematically treat the
functional relationships between CFTR function, commensal and pathogenic microbes, metabolic states, and
innate and acquired immune responses. Dartmouth has an interactive CF research team of 49 faculty members
with extramural funding of $11.1M/year, studying epithelial biology, CFTR correction, host-microbe interactions,
gut dysbiosis and immunity, as well as airway infections and antimicrobial strategies. The Dartmouth CF
Research Center (DartCF) will build on progress made in the past year. We will deploy P30 and institutional
funds to recruit new CF faculty, strengthen our research base, and foster interdisciplinary discovery. Our aims
are: 1) to catalyze new research in CF basic and translational research in areas of interest to NIDDK; 2) to
develop integrative strategies to understand and address CF pathobiology; 3) to create new research tools and
support CF research through outstanding shared services; and 4) to build research capacity in CF locally,
regionally, and nationally. We will focus P30 resources on 1) pioneering transparency and interoperability for CF
datasets, 2) forging collaborations between CF and data-science researchers to mine these datasets for
systems-level perspectives and 3) building on unique Dartmouth longitudinal patient cohorts to explore microbial
community structure in the gut, host-microbe signaling, the effects of existing therapies, and implications for
whole-body disease. A key theme is that dysbioses are interconnected, and that parallel investigations, coupled
by powerful new data-science strategies can understand this complex underlying biology and reveal new
therapeutic approaches. In parallel, we will leverage our research base to support early-stage preclinical target
development. DartCF supports a variety of mechanisms. First, we fund a Pilot Project Project (P3) to develop
new scientific opportunities in NIDDK-revelant areas and to recruit new faculty members to the Center. Second,
we fund three scientific cores to support studies in CF: a Gastrointestinal Biology Core (GIBC), a Clinical and
Translational Research Core (CTRC), and a CF Bioinformatics & Biostatistics Core (CF-BBC). Finally, we
support an Enrichment and Research Administration Core (ERAC) to foster an interactive scientific community,
sponsor retreats and courses, and track program progress. These efforts will identify new CF therapeutic
opportunities, develop novel interventions, monitor the resulting changes body-wide, and track outcomes.
DartCF will intensify the translation of research into improved CF outcomes at Dartmouth.
在囊性纤维化(CF)中,囊性纤维化跨膜传导调节因子(CFTR)的突变释放a
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
DEAN R MADDEN其他文献
DEAN R MADDEN的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('DEAN R MADDEN', 18)}}的其他基金
DartCF: The Dartmouth Cystic Fibrosis Research Center
DartCF:达特茅斯囊性纤维化研究中心
- 批准号:
10895149 - 财政年份:2018
- 资助金额:
$ 4.22万 - 项目类别:
DartCF: The Dartmouth Cystic Fibrosis Research Center
DartCF:达特茅斯囊性纤维化研究中心
- 批准号:
10001759 - 财政年份:2018
- 资助金额:
$ 4.22万 - 项目类别:
DartCF: The Dartmouth Cystic Fibrosis Research Center
DartCF:达特茅斯囊性纤维化研究中心
- 批准号:
10686303 - 财政年份:2018
- 资助金额:
$ 4.22万 - 项目类别:
DartCF: The Dartmouth Cystic Fibrosis Research Center
DartCF:达特茅斯囊性纤维化研究中心
- 批准号:
10678819 - 财政年份:2018
- 资助金额:
$ 4.22万 - 项目类别:
DartCF: The Dartmouth Cystic Fibrosis Research Center
DartCF:达特茅斯囊性纤维化研究中心
- 批准号:
10474845 - 财政年份:2018
- 资助金额:
$ 4.22万 - 项目类别:
DartCF: The Dartmouth Cystic Fibrosis Research Center
DartCF:达特茅斯囊性纤维化研究中心
- 批准号:
10240591 - 财政年份:2018
- 资助金额:
$ 4.22万 - 项目类别:
相似海外基金
Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
- 批准号:
MR/S03398X/2 - 财政年份:2024
- 资助金额:
$ 4.22万 - 项目类别:
Fellowship
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
- 批准号:
EP/Y001486/1 - 财政年份:2024
- 资助金额:
$ 4.22万 - 项目类别:
Research Grant
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
- 批准号:
2338423 - 财政年份:2024
- 资助金额:
$ 4.22万 - 项目类别:
Continuing Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
- 批准号:
MR/X03657X/1 - 财政年份:2024
- 资助金额:
$ 4.22万 - 项目类别:
Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
- 批准号:
2348066 - 财政年份:2024
- 资助金额:
$ 4.22万 - 项目类别:
Standard Grant
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
- 批准号:
2341402 - 财政年份:2024
- 资助金额:
$ 4.22万 - 项目类别:
Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
- 批准号:
AH/Z505481/1 - 财政年份:2024
- 资助金额:
$ 4.22万 - 项目类别:
Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10107647 - 财政年份:2024
- 资助金额:
$ 4.22万 - 项目类别:
EU-Funded
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10106221 - 财政年份:2024
- 资助金额:
$ 4.22万 - 项目类别:
EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
- 批准号:
AH/Z505341/1 - 财政年份:2024
- 资助金额:
$ 4.22万 - 项目类别:
Research Grant