Enrichment and Research Administration Core

浓缩和研究管理核心(ERAC)的总体目标是支持科学 达特茅斯囊性纤维化研究中心(DartCF)的使命：为 CF生物学、上皮功能、微生物定植和宿主反应的新原理的发现，以及 它们在NIDDK感兴趣的领域转化为临床结果。于2018年推出的DartCF将继续 支持三个生物医学研究核心。它将扩大试点计划，以招募新的调查人员并为其提供资金 新的研究方向，包括CF肠道菌群失调、GI微生物群落和肝功能。它还将 支持密集的研究开发计划，并将利用机构资源进行计划 丰富，包括年度专题讨论会和最佳研究做法方面的新培训单元。在以下位置工作 基本和翻译频谱，这些组件将推进新的识别和验证 慢性阻塞性肺疾病的治疗策略。科学领导将由DartCF的Dean Madden博士主任提供 领导团队、内部和外部咨询委员会以及包容各方的教务委员会。美国政府的角色 ERAC将为所有中心提供高效的科学领导、组织支持和财务监督 组件。建立在为其他方案奖制定并在第一年部署的战略的基础上 在资金方面，ERAC将实现以下具体目标：(1)提供科学领导，支持所有 DartCF成员探索新的高影响力研究方向；(2)支持战略研究 发展机遇；(3)促进强有力的科学交流；(4)提供精简的 行政和财政支持，向DartCF和机构领导层提供及时和准确的报告 和NIDDK计划工作人员；以及(5)通过部署机构来丰富科研环境 资源。这些目标中的每一个都将推进DartCF任务。包容、经验丰富的领导层将确定 并为中心教职员工创造新的机会，以从事基础和翻译研究项目， 改善治疗选择和患者结果的目标。该教育项目将提供专家 指导我们的教员，提高他们的研究效率，并产生额外的校外支持 Cf研究。每周进行中的研究系列，其间穿插着受邀的研讨会和一年一度的达特茅斯 Cf务虚会，将维持一个高度整合、互动的科学社区，并刺激探索新的 研究方向。与生物医学研究中心一起，试点和核心基金都将招聘教师 向该中心提供资金，提高他们争取外部资金的能力。计划领导力有很强的跟踪能力 科学合作的记录和二十年的多项目奖项经验。利用这些优势 技能集，我们开发了一个管理核心，致力于提供出色的组织支持 DartCF的研究人员为推动其作为NIDDK支持的CF研究中心的成功而努力。

The overarching goal of the Enrichment & Research Administration Core (ERAC) is to support the scientific mission of the Dartmouth Cystic Fibrosis Research Center (DartCF): to foster a superior environment for discovery of new principles of CF biology, epithelial function, microbial colonization, and host responses, and their translation into clinical outcomes, in areas of interest to NIDDK. Launched in 2018, DartCF will continue to support three Biomedical Research Cores. It will expand its pilot program to recruit new investigators and fund new research directions, including CF gut dysbiosis, GI microbial communities, and liver function. It will also support an intensive research development program and will leverage institutional resources for program enrichment, including annual symposia and new training modules in best research practices. Working across the basic and translational spectrum, these components will advance the identification and validation of new therapeutic strategies in CF. Scientific leadership will be provided by Director Dean Madden, PhD, the DartCF leadership team, Internal and External Advisory Committees, and an inclusive Faculty Council. The role of the ERAC is to provide efficient scientific leadership, organizational support, and fiscal oversight for all Center components. Building on strategies developed for other programmatic awards and deployed in year one of funding, the ERAC will achieve the following Specific Aims: (1) To provide scientific leadership supporting all DartCF members as they explore new high-impact research directions; (2) To support strategic research development opportunities; (3) To facilitate robust scientific communication; (4) To offer streamlined administrative and fiscal support, providing timely and accurate reporting to DartCF and institutional leadership and NIDDK Program staff; and (5) To enrich the scientific and research environment by deploying institutional resources. Each of these aims will advance the DartCF mission. Inclusive, experienced leadership will identify and create new opportunities for Center faculty to pursue basic and translational research projects in CF, with a goal of improving therapeutic options and patient outcomes. The education program will provide expert guidance to our faculty, enhancing their research productivity and generating additional extramural support for CF research. A weekly research-in-progress series, interspersed with invited seminars and an annual Dartmouth CF Retreat, will sustain a highly integrated, interactive scientific community and stimulate the exploration of new research directions. Together with the Biomedical Research Cores, pilot and core funding will both recruit faculty to the Center and increase their ability to compete for extramural funding. Program leadership has a strong track record of scientific collaboration and two decades' experience with multiproject awards. Leveraging these skillsets, we have developed an Administrative Core committed to providing excellent organizational support to the investigators of DartCF and to advancing its success as an NIDDK-supported CF Research Center.