Quantitative 3D imaging of in situ nanoparticle movement and cellular behavior during neuroinflammation
神经炎症过程中纳米粒子原位运动和细胞行为的定量 3D 成像
基本信息
- 批准号:10001544
- 负责人:
- 金额:$ 36.19万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-08-01 至 2023-07-31
- 项目状态:已结题
- 来源:
- 关键词:3-DimensionalAdultBehaviorBiological AssayBiological SciencesBrainBrain DiseasesCellsCentral Nervous System DiseasesClinical SciencesDevelopmental ProcessDiseaseEnvironmentExcisionFoundationsInflammationInjuryLeadMethodologyModelingMolecularMovementNeurologic ProcessProcess AssessmentRattusRegulationResearchSeverity of illnessSliceTechnologyTherapeuticThree-Dimensional ImagingTimeTransgenic OrganismsTranslatingTranslationsautism spectrum disordercell behaviorcellular imagingfluid flowglymphatic systemhuman diseaseimaging modalityin situ imagingin vivoinsightnanoparticleneonatal brainnervous system disorderneuroinflammationperinatal brainquantitative imagingsynaptogenesistherapeutic targetwasting
项目摘要
PROJECT SUMMARY
Currently, the means to gather real-time molecular information from the diseased human brain
is limited, and high-throughput platforms that can assay neurological disease severity
representative of the in vivo environment are still lacking. This proposal reflects a foundational
effort in my lab to generate a high throughout, quantitative, real-time method of imaging cell and
nanoparticle behavior, in 3-dimensions, within the neonatal or perinatal brain in the presence of
disease. We will specifically focus on neuroinflammation as a common disease hallmark and
use a transgenic rat model of autism. This approach will open up new avenues of research in
the life sciences and clinical sciences, by providing a platform for assessment of processes that
are currently inaccessible to high-throughput study, including developmental processes (i.e.
synaptogenesis) and normal regulation of fluid flow (i.e. regulation of waste removal via the
glymphatic system). In addition, tracking and modelling nanoparticle co-localization in, or
interaction with, cells following injury could also provide new potential therapeutic targets.
Developing therapeutic technologies by leveraging their in vivo interactions with common
disease hallmarks can lead to more efficient translation of therapies across diseases with
shared pathophysiological features. Given that inflammation is a common factor across many
central nervous system (CNS) diseases, results are expected to provide insights and translate
from the autism model used in this proposal to other models, including adult, of brain disease.
项目摘要
目前,从患病的人脑中收集实时分子信息的方法
是有限的,高通量平台,可以测定神经系统疾病的严重程度,
仍然缺乏体内环境的代表性。该提案反映了一个基本的
在我的实验室努力产生一个高通量,定量,实时成像细胞的方法,
纳米粒子行为,在三维,在新生儿或围产期脑中的存在,
疾病我们将特别关注神经炎症作为一种常见疾病的标志,
使用转基因自闭症大鼠模型。这种方法将开辟新的研究途径,
生命科学和临床科学,为评估
目前无法进行高通量研究,包括发育过程(即,
突触发生)和流体流动的正常调节(即,经由突触发生的废物去除的调节)。
胶质淋巴系统)。此外,跟踪和建模纳米粒子共定位,或
损伤后与细胞的相互作用也可以提供新的潜在治疗靶点。
通过利用它们与常见的生物活性物质的体内相互作用来开发治疗技术
疾病标志可以导致更有效地翻译各种疾病的治疗方法,
共同的病理生理特征。鉴于炎症是许多疾病的共同因素,
中枢神经系统(CNS)疾病,结果预计将提供见解和翻译
从这个建议中使用的自闭症模型到其他模型,包括成人大脑疾病。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Elizabeth A Nance其他文献
Colocation of Genes Encoding a tRNA-mRNA Hybrid and a Putative Signaling Peptide on Complementary Strands in the Genome of the Hyperthermophilic Bacterium Thermotoga maritima
超嗜热细菌海栖热袍菌基因组中编码 tRNA-mRNA 杂合体和假定信号肽的基因在互补链上的共定位
- DOI:
10.1128/jb.00470-06 - 发表时间:
2006 - 期刊:
- 影响因子:3.2
- 作者:
C. Montero;Derrick L. Lewis;Matthew R. Johnson;S. B. Conners;Elizabeth A Nance;J. Nichols;R. Kelly - 通讯作者:
R. Kelly
Elizabeth A Nance的其他文献
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{{ truncateString('Elizabeth A Nance', 18)}}的其他基金
Combinatorial Neuroprotective Strategies for Preterm Brain Injury
早产儿脑损伤的组合神经保护策略
- 批准号:
10798705 - 财政年份:2023
- 资助金额:
$ 36.19万 - 项目类别:
Enzyme-loaded nanoparticles for neonatal neuroprotection
用于新生儿神经保护的载酶纳米粒子
- 批准号:
10391787 - 财政年份:2021
- 资助金额:
$ 36.19万 - 项目类别:
Enzyme-loaded nanoparticles for neonatal neuroprotection
用于新生儿神经保护的载酶纳米粒子
- 批准号:
10194572 - 财政年份:2020
- 资助金额:
$ 36.19万 - 项目类别:
Quantitative 3D imaging of in situ nanoparticle movement and cellular behavior during neuroinflammation
神经炎症过程中纳米粒子原位运动和细胞行为的定量 3D 成像
- 批准号:
10462583 - 财政年份:2017
- 资助金额:
$ 36.19万 - 项目类别:
Quantitative 3D imaging of in situ nanoparticle movement and cellular behavior during neuroinflammation
神经炎症过程中纳米粒子原位运动和细胞行为的定量 3D 成像
- 批准号:
10708728 - 财政年份:2017
- 资助金额:
$ 36.19万 - 项目类别:
Quantitative 3D imaging of in situ nanoparticle movement and cellular behavior during neuroinflammation
神经炎症过程中纳米粒子原位运动和细胞行为的定量 3D 成像
- 批准号:
10216303 - 财政年份:2017
- 资助金额:
$ 36.19万 - 项目类别:
Quantitative 3D imaging of in situ nanoparticle movement and cellular behavior during neuroinflammation
神经炎症过程中纳米粒子原位运动和细胞行为的定量 3D 成像
- 批准号:
9749975 - 财政年份:2017
- 资助金额:
$ 36.19万 - 项目类别:
Quantitative 3D imaging of in situ nanoparticle movement and cellular behavior during neuroinflammation
神经炎症过程中纳米粒子原位运动和细胞行为的定量 3D 成像
- 批准号:
10392274 - 财政年份:2017
- 资助金额:
$ 36.19万 - 项目类别:
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