2/2 Howard-Georgetown Collaborative Partnership in Cancer Research

2/2 霍华德-乔治敦癌症研究合作伙伴关系

• 批准号: 10004016
• 负责人: Lucile Lauren Adams-Campbell
• 金额: $ 21.81万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10004016
• 关键词: Address; Advanced Malignant Neoplasm; Advisory Committees; Affect; African American; Applications Grants; Award; Biological; Biological Markers; Biomedical Research; Breast Cancer survivor; Candidate Disease Gene; Categories; Chronic stress; Collaborations; Communities; Comprehensive Cancer Center; Data; Discipline; District of Columbia; Elements; Environment; Faculty; Foundations; Funding; Genetic; Goals; Historically Black Colleges and Universities; Individual; Infrastructure; Institution; Knowledge; Lead; Malignant Neoplasms; Mentors; Metabolic; Minority; Mission; Molecular Profiling; Office of Administrative Management; Outcome; Pathway interactions; Patients; Physical activity; Pilot Projects; Policies; Population; Postdoctoral Fellow; Process; Program Evaluation; Publications; Quality of life; Research; Research Personnel; Research Project Grants; Research Proposals; Research Training; Resource Sharing; Resources; Scientist; Social Justice; Structure; Students; Training; Training Programs; Training and Education; Underrepresented Students; Universities; Vision; allostatic load; anticancer research; base; cancer education; cancer health disparity; career development; clinical care; cohort; curriculum development; education research; experience; falls; follow-up; genetic signature; health disparity; innovation; insight; interest; member; non-alcoholic fatty liver disease; programs; recruit; research study; summer research; university student

Overall Abstract The overarching goal of the NCI Collaborative P20 Partnership in Cancer Research is to enhance cancer research capacity at Howard University and increase participation in cancer health disparities research at Georgetown Lombardi Comprehensive Cancer Center (GU). The Partnership goals will be achieved through two primary mechanisms: pilot research projects and cancer research education. The P20 will benefit from the guidance of an Internal Advisory Committee (IAC) made up of highly qualified and experienced scientists. The Research Pilot Projects will fund four 2-year collaborative research pilot projects. Each project will include at least one investigator from Howard and one from Georgetown. The investigators will benefit from the HU/GU CTSA and the Shared Resources available at GU. Pilot project 1 will identify candidate genes and genetic pathways associated with Non-Alcoholic Fatty Liver Disease (NAFLD). The research will inform possible biological mechanisms underlying the molecular and genetic signatures of perturbed metabolic and mechanistic pathways in NAFLD patients in an African–American population. Results may lead to innovative non-invasive biomarkers. Research Project 2 will investigate disparities in chronic stress, quality of life, and physical activity among Black and White breast cancer survivors. This study will provide insight into whether an association exists between physical activity and allostatic load in breast cancer survivors. During the course of the award, the P20 Partnership will elicit two additional pilot studies through a competitive process which will be driven by a merit review by the IAC. The expected outcome of the pilot projects is the submission of successful collaborative grant applications supported by the preliminary data obtained via the pilot research. The C-REP will contribute to the goals of the Partnership by engaging a diverse group students and faculty who are under-represented as investigators in biomedical research. A cohort consisting of a mix of college students in their junior or senior year, graduate and professional students will be recruited annually for an intensive 8-week mentored summer research experience. Follow-up mentoring will be provided to promote entry into a graduate or professional program or postdoctoral research training. Postdoctoral fellows and faculty will receive training and mentoring to support attaining a robust, high quality publication record and submission of highly competitive independent research proposals. Mentoring within the C-REP will occur via teams of at least one faculty member from both institutions. The Howard-Georgetown P20 Partnership brings many strengths including a large pool of under- represented students and faculty at Howard University, extensive research resources through GU, and a foundation of longstanding, productive partnerships between the two institutions.

总体摘要 NCI癌症研究合作P20伙伴关系的总体目标是促进癌症 霍华德大学的研究能力，并增加对癌症健康差异研究的参与 乔治敦隆巴迪综合癌症中心(GU)。伙伴关系目标将通过以下方式实现 两个主要机制：先导研究项目和癌症研究教育。P20将受益于 由高素质和经验丰富的科学家组成的内部咨询委员会(IAC)提供指导。这个 研究试点项目将资助四个为期两年的合作研究试点项目。每个项目将包括 至少一名来自霍华德的调查员和一名来自乔治敦的调查员。调查人员将受益于胡/古 Ctsa和gu提供的共享资源。试点项目1将确定候选基因和基因 与非酒精性脂肪性肝病(NAFLD)相关的途径。这项研究将向可能的 代谢紊乱和机械性疾病分子和遗传特征背后的生物学机制 非裔美国人人群中NAFLD患者的通路。结果可能导致创新的非侵入性 生物标志物。研究项目2将调查慢性压力、生活质量和体力活动方面的差异 在黑人和白人乳腺癌幸存者中。这项研究将提供对是否存在关联的洞察 乳腺癌幸存者的体力活动和不平衡负荷之间的关系。在颁奖过程中，P20 伙伴关系将通过竞争性的过程引发另外两项试点研究，这一过程将由功绩驱动 由IAC审查。试点项目的预期结果是提交成功的合作赠款 通过试点研究获得的初步数据支持的应用。首席代表将为 通过吸纳代表人数不足的不同群体的学生和教职员工，实现伙伴关系的目标 生物医学研究方面的研究人员。由大三或大四的大学生混合而成的群体 今年，研究生和专业学生将每年被招募参加为期8周的强化辅导暑期 研究经验。将提供后续指导，以促进进入研究生或专业人员 项目或博士后研究培训。博士后研究员和教师将接受培训和指导 支持实现稳健、高质量的出版记录，并提交具有高度竞争力的独立 研究建议。C-Rep内部的指导将通过双方至少一名教职员工组成的团队进行 机构。霍华德-乔治敦P20合作伙伴关系带来了许多优势，包括大量低于 代表霍华德大学的学生和教职员工，通过GU获得广泛的研究资源，以及 这是两个机构之间长期、富有成效的伙伴关系的基础。