Exergaming Intervention and Breast Cancer Biomarkers in Black Women

说明(申请人提供)：肥胖本身是一个严重的公共卫生问题，并与绝经后乳腺癌发病率和死亡率的增加有关。这项研究提案将评估一种改善黑人女性体力活动的新方法，与大多数其他种族和民族的女性相比，黑人女性通常体力活动较少，超重和肥胖程度更高。在这项研究中，我们将使用一种新的游戏干预策略，并评估其对体重和与肥胖、胰岛素相关途径和炎症相关的生物标记物的影响。我们提出了一项为期6个月的双臂随机临床干预试验，使用视频游戏与对照组进行比较。我们将100名久坐不动的超重或肥胖女性随机分配到Wii Fit运动干预组或对照组。这项研究的具体目的是：(1)考察在以社区为基础的环境中进行游戏干预的可行性和可接受性。我们将评估总体收益和对干预方案的依从性；(2)探索使用Wii Fit运动对久坐、超重或肥胖黑人女性心血管健康研究终点和体脂百分比的主要影响。据我们所知，这是第一项对成人进行视频游戏干预的研究；(3)研究在成人中收集生物蠕虫的可行性 以社区为基础；(4)探讨游戏干预对生物标志物的影响。

DESCRIPTION (provided by applicant): Obesity itself is a significant public health problem and is associated with increased postmenopausal breast cancer incidence and mortality. This research proposal will assess a novel method to improve physical activity in Black women, who are generally less physically active and more overweight and obese than women of most other racial and ethnic groups. In this study we will use a novel gaming intervention strategy and assess its impact on weight and biomarkers related to obesity, insulin-related pathways and inflammation. We propose a 6 month two-arm randomized clinical intervention trial using video gaming compared to a control group. We will randomize 100 Black sedentary overweight or obese women to either the Wii Fit exercise intervention arm or the control arm. The Specific Aims of the study are: (1) to examine the feasibility and acceptability of an exergaming intervention in a community-based setting. We will assess overall accrual and adherence to the intervention regimen; (2) to explore intervention main effects of exergaming using Wii Fit on study endpoints of cardiovascular fitness and percent body fat in Black women who are sedentary and overweight or obese. To our knowledge, this is the first study investigating a video gaming intervention in adults; (3) to examine the feasibility of collecting biospecimens in a community-based setting; and (4) to explore the impact of the exergaming intervention on biomarkers.