Administrative Core

摘要 本行政核心的首要目标是提供一种手段， 临床前和确诊狼疮的分子谱分析将无缝运作，涵盖许多物流 地区为实现这一目标，提出了三个具体目标：目标1：监督 三个研究项目和另外两个核心（核心1-研究）的业务整合 技术核心;核心2-临床核心）。行政核心将提供治理、基础设施、 预算编制和财务问责制，传播宣传材料，规划会议， 完成所有组成部分的研究项目和核心的行政任务。目标2：促进 中心工作人员和咨询委员会之间进行有意义的互动。两个子目标是 建议：a）继续制定新的倡议和战略，以促进互动， 3个研究项目之间的合作及其与核心的互动; B）促进 中心工作人员和咨询委员会之间的沟通。建议咨询委员会 包括4名具备与拟议研究项目有关的专业知识的研究人员，以及2名非专业人员， 将提供关于患者观点的关键输入，包括招募的可行性，伦理问题， 建议的工作对个人和人口的意义，以及成果的传播。导演和 副主任将组织一年两次的咨询委员会会议，项目负责人将在会上介绍 向小组介绍情况，以评估项目进度、遵守时间表和里程碑的情况，以及 建议的试点/可行性研究的优点。目标3：促进关于以下问题的跨学科转化研究： SLE在纽约大学医学院。三个子项目描述了我们的策略：a）临床/翻译联络： Drs. Izmirly、贝尔蒙特和主任-由于他们出席了为 临床核心-将与其他流变学教师，研究员，居民和医学生互动。他们的 整体参与，预计将促进病人的兴趣和教育和转诊的病人看到的 其他卫生保健提供者。B）试点/可行性项目计划：在医学院内， 在CTSI的支持下，主任和副主任将宣传申请试点的机会， 与SLE相关的可行性项目。主任（作为流变学系主任）和 副主任（医学和病理学教授，教授免疫学课程， 发病机制在医学院和萨克勒生物医学科学研究生院）是很好的- 能够遇到、寻找和鼓励有前途的申请人参加这些项目。（c）浓缩 计划：总监和副总监将与其他项目和核心领导/副领导合作 邀请访问学者与中心成员进行研讨和互动，并安排中心 成员和他们的学生参加科学会议的重要疾病的主题，这个中心。

ABSTRACT The overarching goal of this Administrative Core is to provide a means by which the Translational Center for Molecular Profiling in Preclinical and Established Lupus will function seamlessly, covering many logistic areas. Three Specific Aims are proposed to accomplish this goal: Aim 1: To provide oversight for operational integration of the three Research Projects and two additional Cores (Core 1–Research Technology Core; Core 2–Clinical Core). The Administrative Core will provide governance, infrastructure, budgeting and financial accountability, dissemination of communicative materials, planning meetings and completing administrative tasks for all component Research Projects and Cores. Aim 2: To facilitate meaningful interactions among the Center personnel and the Advisory Committee. Two subaims are proposed: a) to continuously develop new initiatives and strategies to promote the interactions and collaborations among the 3 Research Projects and their interactions with the Cores; b) to facilitate communication between Center personnel and the Advisory Committee. The Advisory Committee is proposed to comprise 4 researchers with expertise relating to the proposed Research Projects, and 2 laypersons who will provide critical input on patients' perspectives with regard to feasibility of recruitment, ethical issues, personal and population meaningfulness of the work proposed, and dissemination of results. The Director and Associate Director will organize twice-yearly Advisory Committee meetings, at which the Project Leads will give presentations to the group to assess project progress, adherence to timelines and milestones, as well as the merit of proposed Pilot/Feasibility Studies. Aim 3: To foster translational, interdisciplinary research on SLE at the NYU School of Medicine. Three Subaims describe our strategies: a) Clinical/Translational Liaison: Drs. Izmirly, Belmont and the Director – by virtue of their attendance at clinical sites providing patients for the Clinical Core – will interact with other Rheumatology faculty, fellows, residents and medical students. Their integral involvement is expected to foster patient interest and education and referral of patients seen by the other health care providers. b) Pilot/Feasibility Project Program: Within the School of Medicine and with support from the CTSI, the Director and Associate Director will publicize the opportunity to apply for Pilot and Feasibility Projects relating to SLE. Both the Director (as Director of the Division of Rheumatology) and Associate Director (as Professor of Medicine and Pathology who teaches courses in immunology and pathogenesis in the School of Medicine and Sackler Graduate School of Biomedical Sciences) are well- positioned to encounter, seek out, and encourage promising applicants for such Projects. c) Enrichment Program: The Director and Associate Director will work with the other Project and Core Leads/Associate Leads to invite visiting scholars to give seminars and interact with members of the Center, and arrange for Center members and their students to attend scientific meetings important for the disease theme of this Center.