Administrative Core

摘要 这一行政核心的首要目标是提供一种手段，使翻译中心 临床前和已确诊的狼疮的分子图谱将无缝运行，涵盖许多逻辑 区域。为实现这一目标提出了三个具体目标：目标1：监督 三个研究项目和两个额外核心的业务整合(核心1--研究 技术核心；核心2-临床核心)。行政核心将提供治理、基础设施、 预算编制和财务问责、传播交流材料、规划会议和 完成所有组件研究项目和核心的管理任务。目标2：促进 中心工作人员和咨询委员会之间有意义的互动。两个子目标是 提议：a)不断制定新的倡议和战略，以促进相互作用和 3个研究项目之间的协作及其与核心的互动；b)促进 中心人员与咨询委员会之间的沟通。建议设立咨询委员会 由4名与拟议研究项目有关的专门知识的研究人员和2名非专业人员组成 将为患者提供关于招募可行性、伦理问题、 建议工作的个人和群体意义，以及成果的传播。署长及 副主任将每年组织两次咨询委员会会议，项目负责人将在会上 向工作组介绍情况，以评估项目进展情况、遵守时间表和里程碑，以及 建议的试验计划/可行性研究的优点。目标3：促进翻译、跨学科研究 纽约大学医学院的系统性红斑狼疮。三个Subaim描述了我们的战略：a)临床/翻译联络： Izmirly博士、Belmont博士和主任-凭借他们在临床站点的出席为患者提供 临床核心-将与其他风湿病学教员、研究员、住院医生和医学生互动。他们的 整体参与有望培养患者的兴趣，并对患者进行教育和转介 其他医疗保健提供者。B)试点/可行性项目方案：在医学院内和与 在CTSI的支持下，主任和副主任将宣传申请试点和 与SLE相关的可行性项目。主任(风湿科主任)和 副主任(医学和病理学教授，教授免疫学和 医学院和萨克勒生物医学研究生院的病因学)是很好的- 定位于遇到、寻找并鼓励有前途的申请者参与这类项目。C)浓缩 计划：主任和副主任将与其他项目和核心主管/副主管一起工作 邀请访问学者举办研讨会，与中心成员互动，并安排中心 会员及其学生参加对本中心疾病主题具有重要意义的科学会议。

ABSTRACT The overarching goal of this Administrative Core is to provide a means by which the Translational Center for Molecular Profiling in Preclinical and Established Lupus will function seamlessly, covering many logistic areas. Three Specific Aims are proposed to accomplish this goal: Aim 1: To provide oversight for operational integration of the three Research Projects and two additional Cores (Core 1–Research Technology Core; Core 2–Clinical Core). The Administrative Core will provide governance, infrastructure, budgeting and financial accountability, dissemination of communicative materials, planning meetings and completing administrative tasks for all component Research Projects and Cores. Aim 2: To facilitate meaningful interactions among the Center personnel and the Advisory Committee. Two subaims are proposed: a) to continuously develop new initiatives and strategies to promote the interactions and collaborations among the 3 Research Projects and their interactions with the Cores; b) to facilitate communication between Center personnel and the Advisory Committee. The Advisory Committee is proposed to comprise 4 researchers with expertise relating to the proposed Research Projects, and 2 laypersons who will provide critical input on patients' perspectives with regard to feasibility of recruitment, ethical issues, personal and population meaningfulness of the work proposed, and dissemination of results. The Director and Associate Director will organize twice-yearly Advisory Committee meetings, at which the Project Leads will give presentations to the group to assess project progress, adherence to timelines and milestones, as well as the merit of proposed Pilot/Feasibility Studies. Aim 3: To foster translational, interdisciplinary research on SLE at the NYU School of Medicine. Three Subaims describe our strategies: a) Clinical/Translational Liaison: Drs. Izmirly, Belmont and the Director – by virtue of their attendance at clinical sites providing patients for the Clinical Core – will interact with other Rheumatology faculty, fellows, residents and medical students. Their integral involvement is expected to foster patient interest and education and referral of patients seen by the other health care providers. b) Pilot/Feasibility Project Program: Within the School of Medicine and with support from the CTSI, the Director and Associate Director will publicize the opportunity to apply for Pilot and Feasibility Projects relating to SLE. Both the Director (as Director of the Division of Rheumatology) and Associate Director (as Professor of Medicine and Pathology who teaches courses in immunology and pathogenesis in the School of Medicine and Sackler Graduate School of Biomedical Sciences) are well- positioned to encounter, seek out, and encourage promising applicants for such Projects. c) Enrichment Program: The Director and Associate Director will work with the other Project and Core Leads/Associate Leads to invite visiting scholars to give seminars and interact with members of the Center, and arrange for Center members and their students to attend scientific meetings important for the disease theme of this Center.