Translational Basic and Clinical Research Training in Rheumatology

风湿病学转化基础和临床研究培训

• 批准号: 10158016
• 负责人: Jill P Buyon
• 金额: $ 31.33万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-05-01 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10158016
• 关键词: Basic Science; Clinical Research; Research Training; Rheumatology

This application for Translational Basic and Clinical Research Training in Rheumatology, under the leadership of Dr. Jill Buyon – Director of the Division of Rheumatology at NYU, who brings translational expertise in SLE and long-standing mentorship – is based on several years of rapid growth and attentive reflection with clear purpose: to support trainees through extended development toward leadership roles and meaningful contributions in science and medicine. Since the standard 2-year fellowship is simply not adequate to prepare fellows for academic careers, this program addresses the need to extend traditional ACGME training. We seek support for 3 physician postgraduates and 1 pre-doctoral MD/PhD trainee to establish an early pipeline to Rheumatology. During a brief hiatus after >30 years of uninterrupted NIAMS T32 funding, the Division has transitioned leadership; re-expanded the ACGME fellowship from 3 to 4 positions annually; fostered advancement of junior faculty with new tenure-track appointments; recruited faculty to fill unmet needs in rheumatology- focused basic science; established centers of translational research that include MiCRA (NYU Microbiome Center for Rheumatology and Autoimmunity), the Colton Center for Autoimmunity, and the Psoriatic Arthritis Center; and instituted SAMPLE (Specimen And Matched Phenotype Linked Evaluation), an IRB-approved biorepository utilizing a uniform consent to provide a shared division-wide resource for clinical and bench researchers. At the core of this proposal is interdisciplinary training along two methodologically distinct research tracks: reinvigoration of basic science career pathways, and clinical research encouraging inquiry relating to disparities and community engagement consistent with the populations we serve. In many cases the enriched training will include an advanced degree. Each track bears the prefix “translational” – be it basic or clinical – to emphasize the common purpose of all healthcare investigators. An Early Scientist Pathway will be offered to MD/PhD candidates (translational-basic track only), with recruitment accomplished by partnering with the directors of the NYU MD/PhD and graduate programs in Immunology/Inflammation and Cell/Molecular Biology. Both tracks are grounded in core disease clusters reflecting faculty expertise and recognized leadership: 1) lupus and diseases of systemic autoimmunity; 2) inflammatory and autoimmune arthritis; and 3) degenerative and metabolic bone disease. Each track incorporates common and highly customized didactics; individualized research training experiences with a project team of Primary, Associate, and Methodological Mentors to bring clinical context to the bench and vice versa; an Advisory Career Development Committee; and planning to support post-T32 advancement to faculty positions. Programmatic success will be evaluated though quarterly meetings of the Executive Committee, semiannual meetings of the External Advisory Committee, and an Annual Retreat. Institutional commitment is strong with support for infrastructure and internal funding for physician- scientists. The NYU-HHC CTSI provides extensive resources available for the proposed training program.

本申请为流变学的转化基础和临床研究培训，根据 Jill Buyon博士的领导-纽约大学流变学系主任， 在SLE和长期指导的专业知识-是基于几年的快速增长和细心 目标明确的反思：通过向领导角色的扩展发展来支持学员， 在科学和医学上做出了重大贡献。由于标准的两年研究金根本不够 为了使研究员为学术生涯做好准备，该计划解决了扩展传统ACGME培训的需要。 我们寻求3名医生研究生和1名博士前MD/PhD实习生的支持，以建立早期管道 到修辞学。在超过30年不间断的NIAMS T32资助之后的短暂中断期间，该司 过渡领导;重新扩大ACGME奖学金从每年3到4个职位;促进发展 初级教师与新的终身职位的轨道任命;招聘教师，以填补在流变学未满足的需求- 专注于基础科学;建立了转化研究中心，包括MiCRA（纽约大学微生物组 风湿病和自身免疫中心），科尔顿自身免疫中心和银屑病关节炎中心 中心;并制定了样本（标本和匹配的表型关联评价），IRB批准的 生物储存库利用统一的同意为临床和实验室提供共享的部门范围资源 研究人员该建议的核心是跨学科培训，沿着两种方法上不同的研究 轨道：重振基础科学职业道路，鼓励与以下方面有关的调查的临床研究 差异和社区参与与我们服务的人群一致。在许多情况下， 培训将包括高级学位。每一个轨道都带有前缀“翻译”-无论是基础还是临床- 强调所有医疗保健研究者的共同目标。早期科学家路径将提供给 MD/PhD候选人（仅限实习-基本轨道），通过与 纽约大学医学博士/博士和免疫学/炎症和细胞/分子生物学研究生课程的主任。 这两个轨道是在核心疾病集群反映教师的专业知识和公认的领导接地：1） 狼疮和系统性自身免疫性疾病; 2）炎性和自身免疫性关节炎;和3）退行性 和代谢性骨病。每一个轨道结合共同的和高度定制的教学法;个性化 研究培训经验与项目团队的主要，副，和方法导师带来 临床背景的板凳，反之亦然;一个咨询职业发展委员会;并计划 支持后T32晋升到教师职位。每季度将对方案的成功进行评估 执行委员会会议、外部咨询委员会半年一次的会议和年度会议。 退机构的承诺是强有力的，支持基础设施和内部资金的医生- 科学家NYU-HHC CTSI为拟议的培训计划提供了广泛的资源。