Studies of Rare Cancers

罕见癌症的研究

• 批准号: 10007419
• 负责人: Katherine McGlynn
• 金额: $ 67.07万
• 依托单位: DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10007419
• 关键词: Affect; Africa South of the Sahara; Alcohol consumption; Antidiabetic Drugs; Area; Asia; Cancer Etiology; Developed Countries; Developing Countries; Diabetes Mellitus; Etiology; Europe; Heavy Drinking; Hepatitis C; Histologic; Incidence; Intrahepatic Cholangiocarcinoma; Investigation; Malignant Neoplasms; Malignant neoplasm of liver; Non-Steroidal Anti-Inflammatory Agents; Obesity; Pharmaceutical Preparations; Primary Malignant Neoplasm of Liver; Primary carcinoma of the liver cells; Research; Risk; Risk Factors; Viral; base; follow-up; insight; interest; mortality; rare cancer; research study

Primary liver cancer, composed of two major histologic types, hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC), is the sixth most frequently occurring cancer in the world and the second most common cause of cancer mortality. While over 80% of liver cancers occur in Asia and sub-Saharan Africa, incidence has been increasing in low-rate areas, such as the U.S. and Europe, for several decades. Our research has been focusing on identifying factors associated with this increase in incidence. While excessive alcohol consumption and hepatitis C virus infection are major risk factors, our research has found that the risk attributable to diabetes and obesity is greater than the risk attributable to other factors. To follow-up on these findings, we are examining the contributions of these factors in 2 U.S. based research studies. We are also examining whether medications such as anti-diabetic drugs, non-steroidal anti-inflammatory drugs and statins affect the risk of liver cancer in developed countries.

原发性肝癌由肝细胞癌（HCC）和肝内胆管癌（ICC）两种主要组织学类型组成，是世界上第六大最常见的癌症，也是癌症死亡的第二大常见原因。 虽然超过 80% 的肝癌发生在亚洲和撒哈拉以南非洲，但几十年来，美国和欧洲等低发病率地区的发病率一直在上升。 我们的研究重点是确定与发病率增加相关的因素。 虽然过量饮酒和丙型肝炎病毒感染是主要危险因素，但我们的研究发现，糖尿病和肥胖造成的风险大于其他因素造成的风险。 为了跟进这些发现，我们正在两项美国研究中研究这些因素的贡献。 我们还在研究抗糖尿病药、非甾体抗炎药和他汀类药物等药物是否会影响发达国家患肝癌的风险。