Studies of Rare Cancers

罕见癌症的研究

• 批准号: 10918980
• 负责人: Katherine McGlynn
• 金额: $ 102.67万
• 依托单位: DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10918980
• 关键词: Affect; Africa South of the Sahara; Alcohol consumption; Alcoholic Hepatitis; Antidiabetic Drugs; Area; Asia; Cancer Etiology; Centers for Disease Control and Prevention (U.S.); Developed Countries; Diabetes Mellitus; Etiology; Europe; HIV; HIV/HCV; Heavy Drinking; Hepatitis C; Hepatitis C co-infection; Hepatitis C virus; Histologic; Incidence; Infection; Intrahepatic Cholangiocarcinoma; Investigation; Malignant Neoplasms; Malignant neoplasm of liver; Non-Steroidal Anti-Inflammatory Agents; Obesity; Persons; Pharmaceutical Preparations; Primary Malignant Neoplasm of Liver; Primary carcinoma of the liver cells; Research; Risk; Risk Factors; United States; Viral; follow-up; insight; interest; mortality; rare cancer; research study

Primary liver cancer, composed of two major histologic types, hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC), is the sixth most frequently occurring cancer in the world and the second most common cause of cancer mortality. While over 80% of liver cancers occur in Asia and sub-Saharan Africa, incidence has been increasing in low-rate areas, such as the U.S. and Europe, for several decades. Our research has been focusing on identifying factors associated with this increase in incidence. According to the Centers for Disease Control and Prevention (CDC), approximately 25% of people with HIV in the United States also have HCV. Infection with both HIV and HCV is called HIV/HCV coinfection. While excessive alcohol consumption and hepatitis C virus infection are major risk factors, our research has found that the risk attributable to diabetes and obesity is greater than the risk attributable to other factors. To follow-up on these findings, we are examining the contributions of these factors in 2 U.S. based research studies. We are also examining whether medications such as anti-diabetic drugs, non-steroidal anti-inflammatory drugs and statins affect the risk of liver cancer in developed countries.

原发性肝癌由肝细胞癌（HCC）和肝内胆管癌（ICC）两种主要组织学类型组成，是世界上第六大最常见的癌症，也是第二大最常见的癌症死亡原因。虽然80%以上的肝癌发生在亚洲和撒哈拉以南非洲，但几十年来，美国和欧洲等低发病率地区的发病率一直在上升。我们的研究一直集中在确定与发病率增加有关的因素。根据美国疾病控制和预防中心（CDC）的数据，在美国，大约25%的艾滋病毒感染者同时患有丙型肝炎病毒。同时感染HIV和HCV称为HIV/HCV合并感染。虽然过量饮酒和丙型肝炎病毒感染是主要的危险因素，但我们的研究发现，糖尿病和肥胖导致的风险大于其他因素导致的风险。为了进一步研究这些发现，我们在两项基于美国的研究中检查了这些因素的贡献。我们还在研究发达国家的抗糖尿病药物、非甾体抗炎药和他汀类药物是否会影响肝癌的风险。

项目成果

Menopausal hormone therapy use and risk of primary liver cancer in the clinical practice research datalink.

• DOI: 10.1002/ijc.29960
• 发表时间: 2016-05-01
• 期刊: International journal of cancer
• 影响因子: 6.4
• 作者: McGlynn KA;Hagberg K;Chen J;Braunlin M;Graubard BI;Suneja N;Jick S;Sahasrabuddhe VV
• 通讯作者: Sahasrabuddhe VV

Geographic variation of intrahepatic cholangiocarcinoma, extrahepatic cholangiocarcinoma, and hepatocellular carcinoma in the United States.

• DOI: 10.1371/journal.pone.0120574
• 发表时间: 2015
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Altekruse SF;Petrick JL;Rolin AI;Cuccinelli JE;Zou Z;Tatalovich Z;McGlynn KA
• 通讯作者: McGlynn KA

Childhood height and birth weight in relation to future prostate cancer risk: a cohort study based on the copenhagen school health records register.

• DOI: 10.1158/1055-9965.epi-13-0712
• 发表时间: 2013-12
• 期刊: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
• 作者: Cook MB;Gamborg M;Aarestrup J;Sørensen TI;Baker JL
• 通讯作者: Baker JL

Metabolic syndrome increases the risk of primary liver cancer in the United States: a study in the SEER-Medicare database.

• DOI: 10.1002/hep.24397
• 发表时间: 2011-08
• 期刊: HEPATOLOGY
• 影响因子: 13.5
• 作者: Welzel, Tania M.;Graubard, Barry I.;Zeuzem, Stefan;El-Serag, Hashem B.;Davila, Jessica A.;McGlynn, Katherine A.
• 通讯作者: McGlynn, Katherine A.

Genetic determinants of serum lipid levels in Chinese subjects: a population-based study in Shanghai, China.

• DOI: 10.1007/s10654-009-9402-3
• 发表时间: 2009
• 期刊: EUROPEAN JOURNAL OF EPIDEMIOLOGY
• 影响因子: 13.6
• 作者: Andreotti, Gabriella;Menashe, Idan;Chen, Jinbo;Chang, Shih-Chen;Rashid, Asif;Gao, Yu-Tang;Han, Tian-Quan;Sakoda, Lori C.;Chanock, Stephen;Rosenberg, Philip S.;Hsing, Ann W.
• 通讯作者: Hsing, Ann W.