Studies of Rare Cancers

罕见癌症的研究

• 批准号: 10263747
• 负责人: Katherine McGlynn
• 金额: $ 148.98万
• 依托单位: DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10263747
• 关键词: Affect; Africa South of the Sahara; Alcohol consumption; Antidiabetic Drugs; Area; Asia; Cancer Etiology; Centers for Disease Control and Prevention (U.S.); Developed Countries; Diabetes Mellitus; Etiology; Europe; HIV; HIV/HCV; Heavy Drinking; Hepatitis C; Hepatitis C co-infection; Hepatitis C virus; Histologic; Incidence; Infection; Intrahepatic Cholangiocarcinoma; Investigation; Malignant Neoplasms; Malignant neoplasm of liver; Non-Steroidal Anti-Inflammatory Agents; Obesity; Pharmaceutical Preparations; Primary Malignant Neoplasm of Liver; Primary carcinoma of the liver cells; Research; Risk; Risk Factors; United States; Viral; base; follow-up; insight; interest; mortality; rare cancer; research study

Primary liver cancer, composed of two major histologic types, hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC), is the sixth most frequently occurring cancer in the world and the second most common cause of cancer mortality. While over 80% of liver cancers occur in Asia and sub-Saharan Africa, incidence has been increasing in low-rate areas, such as the U.S. and Europe, for several decades. Our research has been focusing on identifying factors associated with this increase in incidence. According to the Centers for Disease Control and Prevention (CDC), approximately 25% of people with HIV in the United States also have HCV. Infection with both HIV and HCV is called HIV/HCV coinfection. While excessive alcohol consumption and hepatitis C virus infection are major risk factors, our research has found that the risk attributable to diabetes and obesity is greater than the risk attributable to other factors. To follow-up on these findings, we are examining the contributions of these factors in 2 U.S. based research studies. We are also examining whether medications such as anti-diabetic drugs, non-steroidal anti-inflammatory drugs and statins affect the risk of liver cancer in developed countries.

原发性肝癌，包括两种主要的组织学类型，肝细胞癌 (HCC)和肝内胆管癌（ICC）是第六大最常见的癌症 也是癌症死亡的第二大常见原因。超过80%的肝脏 癌症发生在亚洲和撒哈拉以南非洲，低发病率地区的发病率一直在上升， 例如美国和欧洲，几十年来。我们的研究一直集中在 确定与发病率增加相关的因素。根据该中心 疾病控制和预防中心（CDC），大约25%的艾滋病毒感染者在美国 国家也有HCV。同时感染HIV和HCV称为HIV/HCV合并感染。而 过量饮酒和丙型肝炎病毒感染是主要的危险因素，我们 研究发现，糖尿病和肥胖的风险大于 归因于其他因素。为了跟进这些发现，我们正在研究 这些因素的贡献在2美国的研究。我们也在研究 药物，如抗糖尿病药物、非甾体抗炎药和他汀类药物 影响发达国家的肝癌风险。