Genome sequencing of Lewy Body Dementia and Frontotemporal Dementia: a public resource for the study of Alzheimers disease and related dementias

路易体痴呆和额颞叶痴呆的基因组测序：阿尔茨海默病和相关痴呆研究的公共资源

• 批准号: 10005769
• 负责人: Bryan Traynor
• 金额: $ 5.41万
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10005769
• 关键词: Adult; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Biology; Complex; Congresses; Data; Databases; Defect; Dementia; Development; Diagnosis; Disease; Disease model; Drug Targeting; Environment; Etiology; Evolution; Frontotemporal Dementia; Genes; Genetic; Genetic Research; Genetic Risk; Genome; Goals; Health; Human Genome; Intramural Research Program; Knowledge; Laboratories; Lead; Learning; Lewy Body Dementia; Molecular; Nerve Degeneration; Neurodegenerative Disorders; Neurologic; Neurosciences; Onset of illness; Parkinson Disease; Patients; Personal Satisfaction; Phenotype; Process; Research; Research Personnel; Resources; Risk; Services; Syndrome; Technology; Testing; Time; United States National Institutes of Health; Universities; Work; aging brain; cohort; computing resources; cost; cost effective; drug development; drug discovery; effective intervention; frontotemporal lobar dementia-amyotrophic lateral sclerosis; gene discovery; genetic analysis; genome sequencing; genomic data; improved; insight; model design; nervous system disorder; neurogenetics; online resource; risk variant; sequencing platform; targeted treatment; therapeutic target

The Intramural Research Program is the ideal environment to undertake a project of this magnitude. The Laboratory of Neurogenetics has demonstrated expertise in handling large genomic datasets and has an exemplary track record of gene discovery. It is also remarkably cost effective to undertake this project within the Intramural Research Program. This project will place the Intramural Research Program at the forefront of dementia research and will greatly accelerate the pace of genetic discovery within the field. Specific Aim 1: We will perform genome sequencing of 3,000 LBD cases, 3,000 FTD cases and 2,500 neurologically normal control subjects. The Uniformed Services University will perform the sequencing using the Illumina X10 Sequencing platform. Specific Aim 2: We will analyze the genome sequence data generated from specific aim 1. The purpose of these analyses is to identify genetic loci that alter risk of developing disease and age at disease onset (i.e. genetic modifiers of phenotype). Specific Aim 3: We will make the genome sequence data generated from specific aim 1 publicly available. No embargo will be placed on access to the genome sequence data. These data will be the cornerstone of a new online resource that researchers can access, analyze, and combine with their own data to increase their power to detect new genetic loci. In this way, this unique database will be augmented over time and will greatly accelerate the pace of genetic discovery within the field. Our genome sequencing project is consistent with the strategic goals of the NIA. It aims to understand the dynamics of the aging process by unraveling the complex biology of dementia (Goal A). Unraveling the biology underlying dementia will improve the health, well-being and independence of adults as they age by improving our understanding of the aging brain, Alzheimer's disease, and other neurodegenerative disease (Goal D). We also hope that learning the genetics underlying dementia will provide therapeutic targets for drug discovery and ultimately lead to the development of effective interventions (Goal C). The intent of this project is to establish a public resource that will accelerate high quality research within the field, and that will grow over time (Goal G and H).

校内研究计划是进行这种规模的项目的理想环境。神经遗传学实验室在处理大型基因组数据集方面表现出了专业知识，并在基因发现方面有着出色的记录。在校内研究计划中开展这一项目也具有显著的成本效益。该项目将把校内研究计划置于痴呆症研究的最前沿，并将大大加快该领域内基因发现的步伐。 具体目标1：我们将对3，000例LBD病例、3，000例FTD病例和2，500例神经学正常对照受试者进行基因组测序。Uniformed Services University将使用Illumina X10测序平台进行测序。 具体目标2：我们将分析具体目标1产生的基因组序列数据。这些分析的目的是确定改变疾病发生风险和疾病发作时年龄的遗传基因座（即表型的遗传修饰因子）。 具体目标3：我们将公开从具体目标1产生的基因组序列数据。将不对获取基因组序列数据实行禁运。这些数据将成为一个新的在线资源的基石，研究人员可以访问，分析，并与他们自己的数据联合收割机，以增加他们检测新的遗传位点的能力。通过这种方式，这个独特的数据库将随着时间的推移而扩大，并将大大加快该领域内基因发现的步伐。 我们的基因组测序项目符合NIA的战略目标。它旨在通过解开痴呆症的复杂生物学来了解衰老过程的动态（目标A）。揭示痴呆症的生物学基础将通过提高我们对大脑老化，阿尔茨海默病和其他神经退行性疾病的理解来改善成年人的健康，福祉和独立性（目标D）。我们还希望了解痴呆症的遗传学基础将为药物发现提供治疗靶点，并最终导致有效干预措施的发展（目标C）。该项目的目的是建立一个公共资源，加速该领域的高质量研究，并随着时间的推移而增长（目标G和H）。