Research Support Core

研究支持核心

• 批准号: 10023722
• 负责人: Gregory Evan Miller
• 金额: $ 70.99万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10023722
• 关键词: Addictive Behavior; Affect; Affective; African American; Alcohol or Other Drugs use; Behavior; Biological Assay; Biological Markers; Biometry; Brain; Capital; Centers of Research Excellence; Chronic stress; Cognitive; Collaborations; Communities; Consultations; Consumption; Data; Data Analytics; Development; Disease; Drug abuse; Drug usage; Education; Educational workshop; Etiology; Exposure to; Family; Fatty acid glycerol esters; Food; Functional Magnetic Resonance Imaging; Funding; Generations; Goals; Health; Health Services Research; Immune signaling; Immunology; Inflammation; Inflammatory; Intervention; Investigation; Low income; Mission; Motivation; National Institute of Drug Abuse; Neurobiology; Neurocognitive; Neuroimmune; Neurosciences; Participant; Peripheral; Physiological; Pilot Projects; Plant Roots; Population; Prevention; Preventive; Process; Protocols documentation; Research; Research Personnel; Research Project Grants; Research Project Summaries; Research Support; Resources; Risk; Sampling; Science; Scientist; Skin; Specific qualifier value; Specimen; Stress; Structure; System; Targeted Research; Testing; Training; Transact; Universities; Youth; cardiometabolic risk; cardiometabolism; contextual factors; data analysis pipeline; data exchange; data management; design; drug use vulnerability; emotion regulation; ethnic minority population; experience; image processing; imaging facilities; inflammatory marker; member; minority communities; multilevel analysis; network models; neural circuit; neuroimaging; next generation; prevent; programs; protocol development; psychosocial; ranpirnase; resilience; social; substance misuse; substance misuse prevention; sugar; therapy development; working group

PROJECT SUMMARY: Research Support Core We propose a Research Support Core (RSC) in the context of a P50 Research Center of Excellence: The Center for Translational and Prevention Science (CTAPS). The RSC’s overarching goal is to facilitate a new generation of research focused on (a) stress-induced alterations in brain-immune signaling that create vulnerabilities to substance misuse and cardiometabolic disease, (b) the identification of malleable protective processes that can prevent or mitigate the downstream health consequences of stress, and (c) the development of interventions for African Americans that prevent substance misuse and cardiometabolic disease. To this end, the Research Support Core (RSC) will: (a) oversee and execute analyses of neurocognitive, inflammatory, cardiometabolic, and biostatistical data collected by Center Research Projects (RPs) and Pilot Studies; (b) provide intellectual consultation to Center scientists regarding design protocols, promising targets for research and intervention, and interpretation of results; and (c) sponsor educational and training experiences for CTAPS scientists and the broader scientific community. This Core represents a continuation of a highly productive collaboration between scientists at the University of Georgia and Northwestern University, who together have established pipelines for generating inflammatory, cardiometabolic, and neuroimaging data relevant to African Americans’ substance use and overall health. The RSC comprises substantial intellectual capital and state-of-the science facilities for analysis of neuroimaging data and assaying biomarkers of inflammatory and cardiometabolic functioning. It is composed of three subscores: Neurocognitive (NCO), Inflammatory (INF), and Biostatistical (BSC). The RSC’s aims are to: (1) provide intellectual consultation to RP directors, transdisciplinary work groups, and pilot project investigators, (2) help develop protocols for collecting high-quality neuroimaging, inflammatory, and cardiometabolic data, (3) assay biospecimens for inflammatory and cardiometabolic biomarkers, (4) process and analyze data collected in neuroimaging paradigms, and (5) provide educational experiences to CTAPS scientists, mentees, and affiliates, as well as serving as a resource for the scientific community by providing education through online seminars and preconference workshops.

项目概要：研究支持核心 我们建议在P50卓越研究中心的背景下建立一个研究支持核心（RSC）： 转化和预防科学中心（CTAPS）。RSC的首要目标是促进一个新的 一代人的研究集中在（a）压力引起的脑免疫信号的改变， （B）确定可延展的保护性材料， 可以预防或减轻压力的下游健康后果的过程，以及（c） 为非洲裔美国人制定干预措施，防止药物滥用和心脏代谢 疾病为此，研究支助核心将：（a）监督和分析 中心研究项目收集的神经认知、炎症、心脏代谢和生物统计数据 (RPs)和试点研究;（B）为中心科学家提供有关设计方案的知识咨询， 有希望的研究和干预目标，以及对结果的解释;以及（c）赞助教育和 为CTAPS科学家和广大科学界提供培训经验。这个核心代表了 继续在格鲁吉亚大学的科学家和 西北大学，他们共同建立了产生炎症的管道， 心脏代谢和神经影像学数据相关的非裔美国人的物质使用和整体健康。的 RSC拥有大量的智力资本和用于神经成像分析的最新科学设施 数据并分析炎症和心脏代谢功能的生物标志物。它由三个 分项评分：神经认知（NCO）、炎症（INF）和生物统计学（BSC）。RSC的目标是：（1） 为RP主任、跨学科工作组和试点项目调查人员提供知识咨询， (2)帮助制定收集高质量神经成像、炎症和心脏代谢数据的方案，（3） 测定生物样本的炎症和心脏代谢生物标志物，（4）处理和分析收集的数据 在神经成像范例，和（5）提供教育经验，CTAPS科学家，学员， 附属机构，并通过在线提供教育，为科学界提供资源 研讨会和会前讲习班。