Research Support Core

研究支持核心

• 批准号: 10023722
• 负责人: Gregory Evan Miller
• 金额: $ 70.99万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10023722
• 关键词: Addictive Behavior; Affect; Affective; African American; Alcohol or Other Drugs use; Behavior; Biological Assay; Biological Markers; Biometry; Brain; Capital; Centers of Research Excellence; Chronic stress; Cognitive; Collaborations; Communities; Consultations; Consumption; Data; Data Analytics; Development; Disease; Drug abuse; Drug usage; Education; Educational workshop; Etiology; Exposure to; Family; Fatty acid glycerol esters; Food; Functional Magnetic Resonance Imaging; Funding; Generations; Goals; Health; Health Services Research; Immune signaling; Immunology; Inflammation; Inflammatory; Intervention; Investigation; Low income; Mission; Motivation; National Institute of Drug Abuse; Neurobiology; Neurocognitive; Neuroimmune; Neurosciences; Participant; Peripheral; Physiological; Pilot Projects; Plant Roots; Population; Prevention; Preventive; Process; Protocols documentation; Research; Research Personnel; Research Project Grants; Research Project Summaries; Research Support; Resources; Risk; Sampling; Science; Scientist; Skin; Specific qualifier value; Specimen; Stress; Structure; System; Targeted Research; Testing; Training; Transact; Universities; Youth; cardiometabolic risk; cardiometabolism; contextual factors; data analysis pipeline; data exchange; data management; design; drug use vulnerability; emotion regulation; ethnic minority population; experience; image processing; imaging facilities; inflammatory marker; member; minority communities; multilevel analysis; network models; neural circuit; neuroimaging; next generation; prevent; programs; protocol development; psychosocial; ranpirnase; resilience; social; substance misuse; substance misuse prevention; sugar; therapy development; working group

PROJECT SUMMARY: Research Support Core We propose a Research Support Core (RSC) in the context of a P50 Research Center of Excellence: The Center for Translational and Prevention Science (CTAPS). The RSC’s overarching goal is to facilitate a new generation of research focused on (a) stress-induced alterations in brain-immune signaling that create vulnerabilities to substance misuse and cardiometabolic disease, (b) the identification of malleable protective processes that can prevent or mitigate the downstream health consequences of stress, and (c) the development of interventions for African Americans that prevent substance misuse and cardiometabolic disease. To this end, the Research Support Core (RSC) will: (a) oversee and execute analyses of neurocognitive, inflammatory, cardiometabolic, and biostatistical data collected by Center Research Projects (RPs) and Pilot Studies; (b) provide intellectual consultation to Center scientists regarding design protocols, promising targets for research and intervention, and interpretation of results; and (c) sponsor educational and training experiences for CTAPS scientists and the broader scientific community. This Core represents a continuation of a highly productive collaboration between scientists at the University of Georgia and Northwestern University, who together have established pipelines for generating inflammatory, cardiometabolic, and neuroimaging data relevant to African Americans’ substance use and overall health. The RSC comprises substantial intellectual capital and state-of-the science facilities for analysis of neuroimaging data and assaying biomarkers of inflammatory and cardiometabolic functioning. It is composed of three subscores: Neurocognitive (NCO), Inflammatory (INF), and Biostatistical (BSC). The RSC’s aims are to: (1) provide intellectual consultation to RP directors, transdisciplinary work groups, and pilot project investigators, (2) help develop protocols for collecting high-quality neuroimaging, inflammatory, and cardiometabolic data, (3) assay biospecimens for inflammatory and cardiometabolic biomarkers, (4) process and analyze data collected in neuroimaging paradigms, and (5) provide educational experiences to CTAPS scientists, mentees, and affiliates, as well as serving as a resource for the scientific community by providing education through online seminars and preconference workshops.

项目摘要：研究支持核心 我们在 P50 卓越研究中心的背景下提出了研究支持核心 (RSC)： 转化和预防科学中心（CTAPS）。 RSC 的总体目标是促进新的 一代研究的重点是（a）压力引起的大脑免疫信号改变，从而产生 容易遭受药物滥用和心脏代谢疾病，(b) 确定可塑性保护措施 可以预防或减轻压力对健康造成的下游后果的过程，以及（c） 为非裔美国人制定预防药物滥用和心脏代谢的干预措施 疾病。为此，研究支持核心 (RSC) 将： (a) 监督并执行以下分析： 中心研究项目收集的神经认知、炎症、心脏代谢和生物统计数据 （RP）和试点研究； (b) 向中心科学家提供有关设计方案的智力咨询， 有前途的研究和干预目标以及结果解释； (c) 赞助教育和 为 CTAPS 科学家和更广泛的科学界提供培训经验。这个核心代表了一个 佐治亚大学的科学家和 西北大学共同建立了产生炎症的管道， 与非裔美国人的物质使用和整体健康相关的心脏代谢和神经影像数据。这 RSC 拥有用于神经影像分析的大量智力资本和最先进的科学设施 数据和分析炎症和心脏代谢功能的生物标志物。它由三部分组成 分项评分：神经认知 (NCO)、炎症 (INF) 和生物统计 (BSC)。 RSC 的目标是：(1) 为 RP 主任、跨学科工作组和试点项目研究人员提供智力咨询， (2) 帮助制定收集高质量神经影像、炎症和心脏代谢数据的方案，(3) 测定生物样本的炎症和心脏代谢生物标志物，(4) 处理和分析收集的数据 神经影像范式，(5) 为 CTAPS 科学家、学员和学员提供教育经验 附属机构，并通过在线提供教育作为科学界的资源 研讨会和会前讲习班。