Drug Dependence Clinical Research Program

药物依赖性临床研究计划

• 批准号: 10025048
• 负责人: Peyton Jacob
• 金额: $ 78.29万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10025048
• 关键词: Analytical Chemistry; Applications Grants; Biological Markers; Cannabis; Cardiology; Cessation of life; Chemistry; Clinic; Clinical Pharmacology; Clinical Research; Consult; Country; Data Analyses; Development; Discipline; Drug Addiction; Drug Kinetics; Drug abuse; Drug usage; Exposure to; Faculty; Funding; Future; Goals; Grant; Harm Reduction; Health; Human; Individual; Infrastructure; Institution; Institutional Review Boards; Internal Medicine; Laboratories; Learning; Manuscripts; Measures; Mentors; Methods; Modality; National Institute of Drug Abuse; Occupational Medicine; Pediatrics; Pharmaceutical Preparations; Pharmacology Study; Pharmacotherapy; Pilot Projects; Poison; Postdoctoral Fellow; Preparation; Prevention program; Psychiatry; Psychology; Psychotropic Drugs; Public Health; Public Health Dentistry; Public Policy; Pulmonology; Request for Applications; Research; Research Design; Research Personnel; Research Priority; Research Project Grants; Research Support; Research Training; Resources; Risk; Services; Smoking; Tobacco; Tobacco Dependence; Toxicology; United States National Institutes of Health; addiction; analytical method; career; career development; cost; cost effective; design; drug of abuse; effective therapy; environmental tobacco smoke; experience; exposed human population; human subject; improved; instrument; member; method development; premature; programs; public health research; ranpirnase; response; skills; substance abuse prevention; synergism; thirdhand smoke; tobacco products; treatment program; treatment strategy

ABSTRACT – OVERALL COMPONENT This Core Support Center Grant (P30) application requests continued support for an analytical chemistry laboratory and administrative shared core infrastructure, and support for a pilot project core. The participating, currently funded, constituent projects continue research programs with human laboratory and treatment clinic studies of the clinical pharmacology of abused drugs, pharmacotherapies and other treatment strategies to treat drug abuse and addictions, and studies of the underlying causes and health consequences of drug addiction with the goal of improving therapies, reducing harm, and guiding public policy. Disciplines represented by the participating projects and investigators include psychiatry, psychology, internal medicine, cardiology, occupational medicine, pulmonary medicine, pediatrics, toxicology, environmental public health, dentistry, and chemistry. Currently, most of the supported projects involve the problems associated with tobacco addiction, but some are studies of cannabis and these are increasing with grant proposals submitted or in preparation. We are prepared to support studies of other abused drugs as well, with validated methods used in past studies, as well as the capability to develop new methods. Projects supported by the Pilot Project Core will likely involve other drugs of abuse, facilitated by encouraging scholars in UCSF's Learning for Early Careers in Addiction & Diversity (LEAD) Program whose studies involve a variety of abused substances, to apply for pilot project funding. Our aims are: (1) To provide a state-of-the-art, well equipped and staffed, analytical chemistry laboratory resource for the participating projects of drug abuse researchers at UCSF and at other institutions. (2) A Pilot Project Core with the overarching goal of building a pipeline of investigators with the skills and experience to conduct high quality, cutting edge, and/or rapid response research in substance abuse and prevention. (3) To provide administrative support for manuscript preparation, IRB and related regulatory documents, grants management, and other research administrative services of value participating projects. (4) To provide statistical consulting services regarding study design and data analysis strategies, particularly optimal pharmacokinetic analysis to participating projects. The overall objective is to provide sophisticated analytical laboratory resources with stability of support together with adequate administrative support responsive to the needs of individual funded constituent scientific projects as those projects change and evolve. This facility is a cost-effective shared laboratory resource that enhances and extends research possibilities of investigators currently funded by NIH or other federal or nonfederal agencies to further our understanding of human psychoactive drug use, abuse and addiction, its health consequences and its treatment management.

摘要-整体组件 此核心支持中心补助金（P30）申请要求继续支持分析化学 实验室和行政部门共用核心基础设施，并为试点项目核心提供支助。参与者， 目前已获得资助的组成项目继续与人类实验室和治疗诊所进行研究计划 研究滥用药物的临床药理学、药物疗法和其他治疗策略， 治疗药物滥用和成瘾，以及研究药物滥用的根本原因和健康后果 成瘾的目标是改善治疗，减少伤害，并指导公共政策。学科 以参与项目和研究人员为代表的包括精神病学，心理学，内科学， 心脏病学、职业医学、肺医学、儿科学、毒理学、环境公共卫生、 牙科和化学目前，大部分获资助的项目都涉及以下问题： 烟草成瘾，但有些是大麻的研究，这些研究随着提交的赠款提案而增加 或在准备中。我们也准备用经过验证的方法支持对其他滥用药物的研究 在过去的研究中使用，以及开发新方法的能力。试点项目支持的项目 核心可能会涉及其他滥用药物，通过鼓励加州大学旧金山分校的早期学习学者促进 成瘾与多样性（LEAD）计划的职业生涯，其研究涉及各种滥用物质， 申请试点项目资金。我们的目标是：（1）提供一个最先进的，设备齐全，人员配备， 分析化学实验室资源的药物滥用研究人员在加州大学旧金山分校的参与项目， 在其他机构。(2)核心试点项目，其总体目标是建立一个调查人员管道 具有进行高质量，前沿和/或快速反应研究的技能和经验， 药物滥用和预防。(3)为手稿准备、IRB和 相关的法规文件、赠款管理和其他有价值的研究行政服务 参与项目。(4)提供有关研究设计和数据分析的统计咨询服务 策略，特别是对参与项目的最佳药代动力学分析。总体目标是 提供先进的分析实验室资源，并提供稳定的支持， 行政支助，以满足个别资助的组成科学项目的需要， 项目会变化和发展。该设施是一种具有成本效益的共享实验室资源， 扩展了目前由NIH或其他联邦或非联邦机构资助的研究人员的研究可能性 进一步了解人类精神活性药物的使用、滥用和成瘾及其对健康的影响 及其治疗管理。