Core C: Biomarkers p426-450

核心 C：生物标志物 p426-450

• 批准号: 8592344
• 负责人: Peyton Jacob
• 金额: $ 86.01万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-19 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8592344
• 关键词: Alkaloids; Analytical Chemistry; Biological Markers; Chemistry; Cigarette; Data; Development; Exposure to; Future; Goals; Human; Instruction; Laboratories; Link; Measurement; Measures; Methods; Modeling; Particulate; Phase; Poison; Regulation; Research Personnel; Risk; Sampling; Services; Smoke; Smokeless; Smokeless Tobacco; Smoking; Tobacco; Tobacco smoke; Tobacco use; Toxic effect; Toxin; Validation; anatalline; base; cigarette smoking; exposed human population; improved; novel; tobacco exposure

This Core serves two functions. The first is to provide a service to other TCORS investigators by carrying out the analysis of biofluid samples for their studies. The second is to develop new biomarkers of exposure that can be applied to the studies carried out by TCORS investigators, as well as to advance the field. Our laboratory is able to measure alkaloids and toxic substances in both tobacco products and in tobacco smoke. These measurements are needed for biomarker development and to interpret the biomarker data for distinguishing smokeless from smoked tobacco use. These measurements will include other substances in order to explore relationships between toxins and toxin precursors in tobacco and smoke with exposure determined using biomarkers. The improved exposure assessment measures that we expect to develop, and their application to studies carried out by the TCORS, could serve as models for future studies of the risks of new tobacco products and provide scientific basis for their regulation. RELEVANCE (See instructions): The development and validation of biomarkers is a high priority issue for FDA regulation. Studies of tobacco product chemistry with biomarker analyses may provide information on which substances are associated with toxin exposure in humans. Precursors in smoking products that generate toxic substances might provide leads for reducing the toxicity of new products or be targets for regulation. We expect that our studies will result in improved methods for determining human exposure to toxic substances in tobacco and tobacco smoke.

这个核心有两个功能。第一个是通过执行TCORS的其他调查人员提供服务， 分析他们研究用的生物流体样本第二是开发新的暴露生物标志物， 可以应用于TCORS研究人员进行的研究，以及推进该领域。我们 实验室能够测量烟草制品和烟草烟雾中的生物碱和有毒物质。 这些测量是生物标志物开发和解释生物标志物数据所需的， 区分无烟烟草和吸烟烟草。这些测量将包括其他物质， 探讨烟草和烟雾中毒素及毒素前体物与暴露的关系 使用生物标志物测定。我们预计将开发的改进的暴露评估措施，以及 它们在TCORS进行的研究中的应用，可以作为未来研究 新烟草产品，并为其监管提供科学依据。 相关性（参见说明）： 生物标志物的开发和验证是FDA监管的一个高度优先事项。烟草研究 产品化学和生物标志物分析可提供与哪些物质相关的信息 与人类接触毒素有关吸烟产品中产生有毒物质的前体可能会提供 减少新产品毒性的领导者或监管的目标。我们希望我们的研究 导致用于确定人类暴露于烟草和烟草中的有毒物质的改进的方法 抽烟