Pilot Projects

试点项目计划摘要 试点项目方案的设计是基于提高科学步伐的长期愿景， 佛蒙特州免疫和传染病中心(VCIID)的合作和竞争力。 这与我们第三阶段Cobre计划的总体目标一致，即促进向 独立的可持续发展中心，可以竞争R01、P01、U19和SBIR/STTR的协作性拨款。 根据我们在第一阶段和第二阶段发展的研究专业知识，以及生物医学研究的国家趋势， 我们设计了三类试点项目来扩大VCIID的研究范围：i)基本 免疫学或微生物学研究，II)翻译研究，III)创业火花-VT 通过诊断或治疗将想法从基础研究转化为商业部门的计划 站台。在这三个类别中，重点将放在初级调查人员和合作上， 在VCIID Cobre教职员工以及其他Cobre项目中，如佛蒙特州肺脏中心 (VLC)或附近的盖泽尔/达特茅斯医学院Cobre免疫学/微生物学。严谨的 申请和审查程序将使用NIH指南来实施，以确定最有价值的 科学，并选择最有潜力的长期成功的申请者。此外，试点项目 该计划将通过为初级教师提供更优惠的薪酬线来回应他们的需求，以及 指定的指导。具体目标如下： 具体目标1.实施试点项目计划。我们将为VCIID教职员工提供试点项目资金 保护新拨款的关键数据，重点是与该公司和其他Cobre公司的调查人员合作 计划，核心设施的使用，并提供个性化的指导。 具体目标2.对促进出版物和赠款的试点项目进行严格评估 意见书。我们将使用NIH格式的书面申请，然后是MOST的口头报告 为外部咨询委员会(EAC)建功立业。在那些有很高科学成就的人中，优先考虑的是 适用于初级教员和协作教员。 具体目标3.围绕试点项目的共同研究主题培养P01/U-19工作组 资助金。围绕i)病毒的共同研究主题成立了由指定领导人组成的工作组 免疫学，二)免疫反应的代谢调节，三)免疫的计算机模拟 系统，四)寄生虫的小分子靶标，以及五)感染和 自身免疫性疾病。这些小组可以获得试点资金，以获得协作所需的关键数据 R01、P01、U19或SBIR/STTR授权。

SUMMARY for the Pilot Project Program The design of the Pilot Project Program is based on the long-term vision of enhancing the scientific pace, collaboration, and competitiveness of the Vermont Center for Immunology and Infectious Diseases (VCIID). This is consistent with our overall objective of the Phase III COBRE program to promote the transition to an independent sustainable center that can compete for collaborative R01, P01, U19, and SBIR/STTR grants. Based on our developed research expertise during Phases I and II, and national trends in biomedical research, we have designed three categories of Pilots Projects to expand the VCIID's research portfolio: i) basic research in immunology or microbiology, ii) translational research, and iii) an entrepreneurial SPARK-VT Program to move ideas from basic research into the commercial sector through diagnostic or therapeutic platforms. Emphasis among these three categories will be given to junior investigators and collaborations, both within VCIID COBRE faculty as well as with other COBRE programs, such as the Vermont Lung Center (VLC) or the nearby Geisel/Dartmouth Medical School COBRE in Immunology/Microbiology. A rigorous application and review process will be implemented using NIH guidelines to identify the most meritorious science, and to select applicants with the greatest potential for long-term success. In addition, the Pilot Project Program will be responsive to the needs of junior faculty by providing them with a more favorable pay line, and assigned mentoring. The Specific Aims are thus: Specific Aim 1. Implement a Pilot Project Program. We will provide Pilot Project funds to VCIID faculty to secure critical data for new grants, with emphasis on collaborations with investigators in this and other COBRE programs, use of core facilities, and with the provision of personalized mentoring. Specific Aim 2. Provide rigorous evaluation of Pilot Projects to promote publications and grant submissions. We will use an NIH format of written applications followed by oral presentations of the most meritorious to the External Advisory Committee (EAC). Among those with high scientific merit, preference will be given for junior faculty and collaborating faculty. Specific Aim 3. Foster P01/U-19 working groups around common research themes of the Pilot Project Grants. Working groups with appointed leaders have been formed around common research themes in i) viral immunology, ii) metabolic regulation of the immune response, iii) computational modeling of the immune system, iv) small molecule targets for parasites, and v) sex differences in susceptibility to infectious and autoimmune diseases. These groups could receive pilot funding to get critical data needed for collaborative R01, P01, U19, or SBIR/STTR grants.