Pilot Projects

试点项目

• 批准号: 10006840
• 负责人: Ralph C Budd
• 金额: $ 44.7万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-05 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10006840
• 关键词: Advisory Committees; Autoimmune Diseases; Award; Basic Science; Biology; Biomedical Research; Categories; Centers of Research Excellence; Collaborations; Commercial Sectors; Communicable Diseases; Computer Models; Core Facility; Data; Development; Diagnostic; Evaluation; Experimental Designs; Faculty; Fostering; Funding; Future; Goals; Grant; Guidelines; Immune response; Immune system; Immunobiology; Immunology; Individual; Infection; Infectious Diseases Research; Interdisciplinary Study; Lung; Mentors; Metabolic; Microbiology; Oral; Parasites; Phase; Pilot Projects; Predisposition; Process; Publications; Research; Research Personnel; Science; Secure; Sex Differences; Small Business Innovation Research Grant; Small Business Technology Transfer Research; Therapeutic; Time; Translational Research; United States National Institutes of Health; Vermont; Viral; Vision; base; commercialization; design; immunoregulation; medical schools; meetings; preference; programs; small molecule; success; translational diagnostics; trend; working group

SUMMARY for the Pilot Project Program The design of the Pilot Project Program is based on the long-term vision of enhancing the scientific pace, collaboration, and competitiveness of the Vermont Center for Immunology and Infectious Diseases (VCIID). This is consistent with our overall objective of the Phase III COBRE program to promote the transition to an independent sustainable center that can compete for collaborative R01, P01, U19, and SBIR/STTR grants. Based on our developed research expertise during Phases I and II, and national trends in biomedical research, we have designed three categories of Pilots Projects to expand the VCIID's research portfolio: i) basic research in immunology or microbiology, ii) translational research, and iii) an entrepreneurial SPARK-VT Program to move ideas from basic research into the commercial sector through diagnostic or therapeutic platforms. Emphasis among these three categories will be given to junior investigators and collaborations, both within VCIID COBRE faculty as well as with other COBRE programs, such as the Vermont Lung Center (VLC) or the nearby Geisel/Dartmouth Medical School COBRE in Immunology/Microbiology. A rigorous application and review process will be implemented using NIH guidelines to identify the most meritorious science, and to select applicants with the greatest potential for long-term success. In addition, the Pilot Project Program will be responsive to the needs of junior faculty by providing them with a more favorable pay line, and assigned mentoring. The Specific Aims are thus: Specific Aim 1. Implement a Pilot Project Program. We will provide Pilot Project funds to VCIID faculty to secure critical data for new grants, with emphasis on collaborations with investigators in this and other COBRE programs, use of core facilities, and with the provision of personalized mentoring. Specific Aim 2. Provide rigorous evaluation of Pilot Projects to promote publications and grant submissions. We will use an NIH format of written applications followed by oral presentations of the most meritorious to the External Advisory Committee (EAC). Among those with high scientific merit, preference will be given for junior faculty and collaborating faculty. Specific Aim 3. Foster P01/U-19 working groups around common research themes of the Pilot Project Grants. Working groups with appointed leaders have been formed around common research themes in i) viral immunology, ii) metabolic regulation of the immune response, iii) computational modeling of the immune system, iv) small molecule targets for parasites, and v) sex differences in susceptibility to infectious and autoimmune diseases. These groups could receive pilot funding to get critical data needed for collaborative R01, P01, U19, or SBIR/STTR grants.

试点项目计划摘要 试点项目方案的设计是基于提高科学步伐的长期愿景， 佛蒙特州免疫学和传染病中心 (VCIID) 的合作和竞争力。 这与我们第三阶段 COBRE 计划的总体目标是一致的，即促进向 独立的可持续发展中心，可以竞争 R01、P01、U19 和 SBIR/STTR 协作赠款。 基于我们在第一阶段和第二阶段开发的研究专业知识以及生物医学研究的国家趋势， 我们设计了三类试点项目来扩展 VCIID 的研究组合： i) 基础 免疫学或微生物学研究，ii) 转化研究，以及 iii) 创业型 SPARK-VT 通过诊断或治疗将想法从基础研究转移到商业领域的计划 平台。这三个类别中的重点将放在初级研究人员和合作上， VCIID COBRE 教员以及其他 COBRE 项目（例如佛蒙特州肺中心） (VLC) 或附近的 Geisel/达特茅斯医学院 COBRE 免疫学/微生物学专业。严格的 申请和审查过程将使用 NIH 指南来实施，以确定最有价值的 科学，并选择最有长期成功潜力的申请人。此外，试点项目 该计划将通过为初级教师提供更优惠的薪酬线来满足他们的需求，并且 指派辅导。具体目标是： 具体目标 1. 实施试点项目计划。我们将向 VCIID 教师提供试点项目资金 确保新拨款的关键数据，重点是与本项和其他 COBRE 的研究人员合作 计划、核心设施的使用以及提供个性化指导。 具体目标 2. 对试点项目进行严格评估，以促进出版物和资助 意见书。我们将使用 NIH 格式的书面申请，然后口头介绍最 外部咨询委员会 (EAC) 的功劳。具有较高科学价值者优先考虑 授予初级教师和合作教师。 具体目标 3. 围绕试点项目的共同研究主题建立 P01/U-19 工作组 补助金。围绕以下共同研究主题成立了由指定领导组成的工作组：i) 病毒 免疫学，ii) 免疫反应的代谢调节，iii) 免疫的计算模型 系统，iv) 寄生虫的小分子靶点，以及 v) 对传染性和传染性的易感性的性别差异 自身免疫性疾病。这些团体可以获得试点资金，以获得协作所需的关键数据 R01、P01、U19 或 SBIR/STTR 补助金。