Vermont Immunobiology / Infectious Diseases Center

佛蒙特州免疫生物学/传染病中心

• 批准号: 6962012
• 负责人: Ralph C Budd
• 金额: $ 236.65万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6962012
• 关键词: clinical research; communicable diseases; immune response; immunology; university

DESCRIPTION (provided by applicant): This application proposes the establishment of a Center of Biomedical Research Excellence (COBRE) in Immune Responses to Infectious Pathogens at The University of Vermont (UVM). It will bring together talented senior mentoring faculty and highly promising junior faculty from 6 departments and 3 colleges. An immunologist Director (Dr. Ralph Budd), a microbiologist Co-Director (Dr. Gary Ward), a total of 7 senior mentoring faculty, and Internal and External Advisory Committees will work closely together to provide an intellectual infrastructure for 5 junior faculty, and initiate the Vermont Immunobiology/Infectious Diseases Center (VIC). The specific aims of the proposal are: Specific Aim 1; Establish the research and intellectual infrastructure to support a University-wide center for the study of the immune responses to infectious pathogens. a. Establish a mentoring program to support junior Immunology/Microbiology faculty that will include direct assignment of two senior faculty for each junior faculty, offer courses on grant writing, ethics in science, and career counseling. b. Expand cores in Proteomics and Microarray that will benefit both the junior and senior mentoring faculty. c. Establish a University-wide seminar series in Immunology/Infectious Diseases, as well as an annual retreat for all COBRE personnel, and Internal and External Advisory Committees. d. Establish a mechanism of communication between basic scientists and clinicians that facilitates development of translational research. e. Promote a stronger training environment for Graduate Education in Immunology/Infectious Diseases, both at the basic and clinical levels. f. Recruitment of 3 new faculty in Immunology, Infectious Diseases, and microbial pathogenesis. Specifjc Aim 2; Support the research development of a group of junior faculty who will be the future leaders of the VIC. a. Jonathan Boyson, Ph.D. Molecular Determinants of iNKT cell Activation by CDld and Its Ligands. b. Beth D. Kirkpatrick, M.D. T Cells and Innate Immunity to Cryptosporidium parvum c. Christopher Huston, M.D. Entamoeba histolytica phagocytosis and inflammation. d. Mariana Matrajt, Ph.D. Subversion of Host Cell Signaling to Toxoplasma gondii e. M. Gustavo Pedraza, Ph.D. The effect of anthrax toxin on p38 MAP kinase activation

描述(由申请人提供)： 这项申请建议在佛蒙特州大学(UVM)建立一个生物医学研究卓越中心(COBRE)，研究传染病病原体的免疫反应。它将汇集来自6个系和3个学院的有才华的高级指导教师和非常有前途的初级教师。一名免疫学家主任(Ralph Budd博士)、一名微生物学家联席主任(Gary Ward博士)、总共7名高级指导教师以及内部和外部咨询委员会将密切合作，为5名初级教师提供智力基础设施，并发起佛蒙特州免疫生物学/传染病中心(VIC)。这项建议的具体目标是： 具体目标1；建立研究和智力基础设施，以支持全大学范围内研究对传染病病原体的免疫反应的中心。 A.建立一个辅导计划，以支持初级免疫学/微生物学教员，其中将包括直接 为每个初级教员指派两名高级教员，提供有关拨款撰写、科学伦理和职业咨询的课程。 B.扩展蛋白质组学和微阵列的核心，使初级和高级指导教师都受益。 C.在大学范围内举办免疫学/传染病系列研讨会，并为所有Cobre人员以及内部和外部咨询委员会举办年度务虚会。 D.建立基础科学家和临床医生之间的沟通机制，促进转化性研究的发展。 E.促进在基础和临床两级加强免疫学/传染病研究生教育的培训环境。 F.招聘免疫学、传染病和微生物发病机制方面的3名新教员。 支持一批初级教员的研究开发，他们将成为VIC的未来领导者。 A.乔纳森·博伊森博士。CDLD及其配体激活iNKT细胞的分子决定因素。 B.Beth D.Kirkpatrick，M.D.T细胞与对微小隐孢子虫的天然免疫 C.Christopher Huston，M.D.溶组织内阿米巴吞噬和炎症。 D.Mariana Matrajt博士：宿主细胞对弓形虫信号的颠覆 E.M.Gustavo Pedraza，Ph.D.炭疽毒素对p38 MAP激酶激活的影响