Vermont Center for Immunobiology/Infectious Diseases (VCIID)

佛蒙特州免疫生物学/传染病中心 (VCIID)

• 批准号: 10395160
• 负责人: Ralph C Budd
• 金额: $ 30.89万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10395160
• 关键词: Address; Affect; Animal Model; Apoptosis; Apoptotic; Architecture; Atmosphere; Autoimmune; Autoimmune Diseases; Autoimmunity; Award; Basic Science; Biological; Biology; Bone Marrow; CNS autoimmune disease; Cell physiology; Cells; Centers of Research Excellence; Chimera organism; Chronic; Chronic Disease; Clinical assessments; Collaborations; Communicable Diseases; Core Facility; Coupled; Data; Demyelinating Diseases; Development; Discipline of obstetrics; Disease; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogen Receptors; Estrogens; Estrous Cycle; Excision; Experimental Autoimmune Encephalomyelitis; Faculty; Female; Flow Cytometry; Fostering; Functional disorder; Funding; Future; Gene Expression Profiling; Gene Targeting; Genetic; Goals; Gonadal Steroid Hormones; Gynecology; Immune; Immune response; Immune system; Immunobiology; Immunology; Incidence; Infection; Inflammation; Inflammatory; Investigation; Knockout Mice; Lead; Libido; Lupus; Mentors; Microglia; Mitogen-Activated Protein Kinases; Modeling; Molecular; Multiple Sclerosis; Mus; Myelogenous; Myeloid Cells; Neuraxis; Nuclear Receptors; Organ; Ovarian; Ovarian Follicle; Ovary; Parents; Pathogenesis; Pathology; Pathway interactions; Phagocytes; Phase; Phenotype; Physicians; Pilot Projects; Polycystic Ovary Syndrome; Positioning Attribute; Prevalence; Process; Publishing; Receptor Signaling; Regulation; Reproductive Physiology; Reproductive Sciences; Research; Research Personnel; Research Project Grants; Role; Scientist; Severity of illness; Sex Differences; Side; Signal Transduction; Strategic Planning; Talents; Testing; Time; Tissues; United States National Institutes of Health; Universities; Vermont; Woman; Women' s Health; cell type; conditional knockout; granulosa cell; immune function; in vitro Model; in vivo; insight; interdisciplinary collaboration; interest; macrophage; member; microbial; mouse model; multidisciplinary; primary ovarian insufficiency; ranpirnase; receptor; reproductive; reproductive function; reproductive hormone; reproductive organ; response; sex; tool

Abstract: scope of parent award and relevance to the NOSI on women's health The parent award, P30 GM118228, COBRE Phase III, supports the Vermont Center for Immunology and Infectious Diseases (VCIID) at the University of Vermont (UVM). The VCIID represents a multidisciplinary group of scientists and clinicians undertaking collaborative research in basic immunology, autoimmunity, microbial pathogenesis, and host response to infections. The keystone of the VCIID is scientific excellence through dedicated mentoring of talented junior faculty in an atmosphere that is both engaging and rigorous. In Phase III we seek to coalesce our mutual interests along research lines that will maintain our competitiveness and encourage basic, translational, and entrepreneurial research projects. We will foster this effort through the support of Pilot Project and Core Facilities, and administrative support. This Supplement Application represents a collaboration between two VCIID faculty members who are basic researchers, and two physician-scientists in the department of Department of Obstetrics, Gynecology and Reproductive Sciences. On both sides, there is a junior investigator paired with a senior investigator (respectively: Dr. Krementsov and Dr. Teuscher from VCIID; Dr. Brodeur and Dr. McGee from Ob-Gyn), which fits with VCIID's goal of support for junior faculty, as well as cross-departmental and interdisciplinary collaboration. The scientific goals of this Supplement Application are to investigate the mechanisms regulating innate immune cell functionality in the context of autoimmune disease and normal reproductive function. As such, this fits well within the scope of the VCIID, which supports basic immunology and autoimmunity research. With regard to relevance to women's health, in this supplement application, we propose a basic science approach to dissect molecular mechanisms whereby female reproductive hormones regulate immune cell function in the context of: 1) an autoimmune disease (MS, with highly biased incidence in females), and 2) female reproductive organ function. The NOSI states that the “proposed research must address at least one of the strategic goals of the 2019-2023 Trans-NIH Strategic Plan for Women's Health Research”. Our proposed research will address Strategic Objectives 1.1 (basic biology of sex differences), 1.2 (influence of sex on disease), and 1.5 (research on female reproductive function).

摘要：父母奖励的范围及其与妇女健康国家信息系统的相关性

项目成果

Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2.

• DOI: 10.1126/science.abg5827
• 发表时间: 2021-08-20
• 期刊: Science (New York, N.Y.)
• 作者: Drayman N;DeMarco JK;Jones KA;Azizi SA;Froggatt HM;Tan K;Maltseva NI;Chen S;Nicolaescu V;Dvorkin S;Furlong K;Kathayat RS;Firpo MR;Mastrodomenico V;Bruce EA;Schmidt MM;Jedrzejczak R;Muñoz-Alía MÁ;Schuster B;Nair V;Han KY;O'Brien A;Tomatsidou A;Meyer B;Vignuzzi M;Missiakas D;Botten JW;Brooke CB;Lee H;Baker SC;Mounce BC;Heaton NS;Severson WE;Palmer KE;Dickinson BC;Joachimiak A;Randall G;Tay S
• 通讯作者: Tay S

Immune Regulation in Pregnancy: A Matter of Perspective?

• DOI: 10.1016/j.ogc.2016.07.004
• 发表时间: 2016-12
• 期刊: Obstetrics and gynecology clinics of North America
• 影响因子: 3.2
• 作者: Bonney EA

Oxidative stress in chronic lung disease: From mitochondrial dysfunction to dysregulated redox signaling.

• DOI: 10.1016/j.mam.2018.08.001
• 发表时间: 2018-10
• 期刊: Molecular aspects of medicine
• 影响因子: 10.6
• 作者: van der Vliet A;Janssen-Heininger YMW;Anathy V
• 通讯作者: Anathy V

Kinetics of Postpartum Mesenteric Artery Structure and Function Relative to Pregnancy and Lactation in Mice.

• DOI: 10.1007/s43032-020-00402-4
• 发表时间: 2021-04
• 期刊: Reproductive sciences (Thousand Oaks, Calif.)
• 作者: Gokina NI;Fairchild RI;Bishop NM;Dawson TE;Prakash K;Bonney EA
• 通讯作者: Bonney EA

Altered gastrointestinal motility involving autoantibodies in the experimental autoimmune encephalomyelitis model of multiple sclerosis.

• DOI: 10.1111/nmo.13349
• 发表时间: 2018-09
• 期刊: Neurogastroenterology and motility
• 影响因子: 3.5
• 作者: Spear ET;Holt EA;Joyce EJ;Haag MM;Mawe SM;Hennig GW;Lavoie B;Applebee AM;Teuscher C;Mawe GM
• 通讯作者: Mawe GM