Vermont Center for Immunobiology/Infectious Diseases (VCIID)

佛蒙特州免疫生物学/传染病中心 (VCIID)

• 批准号: 10395160
• 负责人: Ralph C Budd
• 金额: $ 30.89万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10395160
• 关键词: Address; Affect; Animal Model; Apoptosis; Apoptotic; Architecture; Atmosphere; Autoimmune; Autoimmune Diseases; Autoimmunity; Award; Basic Science; Biological; Biology; Bone Marrow; CNS autoimmune disease; Cell physiology; Cells; Centers of Research Excellence; Chimera organism; Chronic; Chronic Disease; Clinical assessments; Collaborations; Communicable Diseases; Core Facility; Coupled; Data; Demyelinating Diseases; Development; Discipline of obstetrics; Disease; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogen Receptors; Estrogens; Estrous Cycle; Excision; Experimental Autoimmune Encephalomyelitis; Faculty; Female; Flow Cytometry; Fostering; Functional disorder; Funding; Future; Gene Expression Profiling; Gene Targeting; Genetic; Goals; Gonadal Steroid Hormones; Gynecology; Immune; Immune response; Immune system; Immunobiology; Immunology; Incidence; Infection; Inflammation; Inflammatory; Investigation; Knockout Mice; Lead; Libido; Lupus; Mentors; Microglia; Mitogen-Activated Protein Kinases; Modeling; Molecular; Multiple Sclerosis; Mus; Myelogenous; Myeloid Cells; Neuraxis; Nuclear Receptors; Organ; Ovarian; Ovarian Follicle; Ovary; Parents; Pathogenesis; Pathology; Pathway interactions; Phagocytes; Phase; Phenotype; Physicians; Pilot Projects; Polycystic Ovary Syndrome; Positioning Attribute; Prevalence; Process; Publishing; Receptor Signaling; Regulation; Reproductive Physiology; Reproductive Sciences; Research; Research Personnel; Research Project Grants; Role; Scientist; Severity of illness; Sex Differences; Side; Signal Transduction; Strategic Planning; Talents; Testing; Time; Tissues; United States National Institutes of Health; Universities; Vermont; Woman; Women' s Health; cell type; conditional knockout; granulosa cell; immune function; in vitro Model; in vivo; insight; interdisciplinary collaboration; interest; macrophage; member; microbial; mouse model; multidisciplinary; primary ovarian insufficiency; ranpirnase; receptor; reproductive; reproductive function; reproductive hormone; reproductive organ; response; sex; tool

Abstract: scope of parent award and relevance to the NOSI on women's health The parent award, P30 GM118228, COBRE Phase III, supports the Vermont Center for Immunology and Infectious Diseases (VCIID) at the University of Vermont (UVM). The VCIID represents a multidisciplinary group of scientists and clinicians undertaking collaborative research in basic immunology, autoimmunity, microbial pathogenesis, and host response to infections. The keystone of the VCIID is scientific excellence through dedicated mentoring of talented junior faculty in an atmosphere that is both engaging and rigorous. In Phase III we seek to coalesce our mutual interests along research lines that will maintain our competitiveness and encourage basic, translational, and entrepreneurial research projects. We will foster this effort through the support of Pilot Project and Core Facilities, and administrative support. This Supplement Application represents a collaboration between two VCIID faculty members who are basic researchers, and two physician-scientists in the department of Department of Obstetrics, Gynecology and Reproductive Sciences. On both sides, there is a junior investigator paired with a senior investigator (respectively: Dr. Krementsov and Dr. Teuscher from VCIID; Dr. Brodeur and Dr. McGee from Ob-Gyn), which fits with VCIID's goal of support for junior faculty, as well as cross-departmental and interdisciplinary collaboration. The scientific goals of this Supplement Application are to investigate the mechanisms regulating innate immune cell functionality in the context of autoimmune disease and normal reproductive function. As such, this fits well within the scope of the VCIID, which supports basic immunology and autoimmunity research. With regard to relevance to women's health, in this supplement application, we propose a basic science approach to dissect molecular mechanisms whereby female reproductive hormones regulate immune cell function in the context of: 1) an autoimmune disease (MS, with highly biased incidence in females), and 2) female reproductive organ function. The NOSI states that the “proposed research must address at least one of the strategic goals of the 2019-2023 Trans-NIH Strategic Plan for Women's Health Research”. Our proposed research will address Strategic Objectives 1.1 (basic biology of sex differences), 1.2 (influence of sex on disease), and 1.5 (research on female reproductive function).

摘要：家长奖励的范围以及与 NOSI 妇女健康的相关性 家长奖 P30 GM118228，COBRE III 期，支持佛蒙特州免疫学中心和 佛蒙特大学 (UVM) 传染病 (VCIID)。 VCIID 代表一个多学科团体 科学家和临床医生在基础免疫学、自身免疫、微生物方面进行合作研究 发病机制和宿主对感染的反应。 VCIID 的基石是科学卓越 在既有吸引力又严谨的氛围中对有才华的初级教师进行专门指导。第三阶段 我们寻求沿着研究方向结合我们的共同利益，以保持我们的竞争力和 鼓励基础、转化和创业研究项目。我们将通过以下方式促进这一努力 试点项目和核心设施的支持以及行政支持。 此补充应用程序代表了两名具有基础知识的 VCIID 教员之间的合作 妇产科的研究人员和两名医师科学家 生殖科学。两侧各有一名初级调查员和一名高级调查员配对 （分别：来自 VCIID 的 Krementsov 博士和 Teuscher 博士；来自 Ob-Gyn 的 Brodeur 博士和 McGee 博士） 符合 VCIID 支持初级教师以及跨部门和跨学科的目标 合作。本补充申请的科学目标是研究调节机制 自身免疫性疾病和正常生殖功能背景下的先天免疫细胞功能。像这样， 这非常适合 VCIID 的范围，它支持基础免疫学和自身免疫研究。 关于与女性健康的相关性，在这个补充申请中，我们提出了一个基础科学 剖析女性生殖激素调节免疫细胞的分子机制的方法 在以下情况下发挥作用：1) 自身免疫性疾病（MS，女性发病率高度偏向），2) 女性 生殖器官功能。 NOSI 指出，“拟议的研究必须至少解决以下问题之一： 2019-2023 年跨 NIH 女性健康研究战略计划的战略目标”。我们提出的建议 研究将涉及战略目标 1.1（性别差异的基本生物学）、1.2（性别对性别差异的影响） 疾病）和1.5（女性生殖功能研究）。

项目成果

Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2.

• DOI: 10.1126/science.abg5827
• 发表时间: 2021-08-20
• 期刊: Science (New York, N.Y.)
• 作者: Drayman N;DeMarco JK;Jones KA;Azizi SA;Froggatt HM;Tan K;Maltseva NI;Chen S;Nicolaescu V;Dvorkin S;Furlong K;Kathayat RS;Firpo MR;Mastrodomenico V;Bruce EA;Schmidt MM;Jedrzejczak R;Muñoz-Alía MÁ;Schuster B;Nair V;Han KY;O'Brien A;Tomatsidou A;Meyer B;Vignuzzi M;Missiakas D;Botten JW;Brooke CB;Lee H;Baker SC;Mounce BC;Heaton NS;Severson WE;Palmer KE;Dickinson BC;Joachimiak A;Randall G;Tay S
• 通讯作者: Tay S

Immune Regulation in Pregnancy: A Matter of Perspective?

• DOI: 10.1016/j.ogc.2016.07.004
• 发表时间: 2016-12
• 期刊: Obstetrics and gynecology clinics of North America
• 影响因子: 3.2
• 作者: Bonney EA

Kinetics of Postpartum Mesenteric Artery Structure and Function Relative to Pregnancy and Lactation in Mice.

• DOI: 10.1007/s43032-020-00402-4
• 发表时间: 2021-04
• 期刊: Reproductive sciences (Thousand Oaks, Calif.)
• 作者: Gokina NI;Fairchild RI;Bishop NM;Dawson TE;Prakash K;Bonney EA
• 通讯作者: Bonney EA

Altered gastrointestinal motility involving autoantibodies in the experimental autoimmune encephalomyelitis model of multiple sclerosis.

• DOI: 10.1111/nmo.13349
• 发表时间: 2018-09
• 期刊: Neurogastroenterology and motility
• 影响因子: 3.5
• 作者: Spear ET;Holt EA;Joyce EJ;Haag MM;Mawe SM;Hennig GW;Lavoie B;Applebee AM;Teuscher C;Mawe GM
• 通讯作者: Mawe GM

Oxidative stress in chronic lung disease: From mitochondrial dysfunction to dysregulated redox signaling.

• DOI: 10.1016/j.mam.2018.08.001
• 发表时间: 2018-10
• 期刊: Molecular aspects of medicine
• 影响因子: 10.6
• 作者: van der Vliet A;Janssen-Heininger YMW;Anathy V
• 通讯作者: Anathy V