Collaborative Study on the Genetics of Alcoholism (COGA)

酒精中毒遗传学合作研究 (COGA)

• 批准号: 10006780
• 负责人: TATIANA M. FOROUD
• 金额: $ 723.34万
• 依托单位: SUNY DOWNSTATE MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-09-29 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10006780
• 关键词: Achievement; Address; Adolescence; Affect; Alcohol consumption; Alcohols; Architecture; Assessment tool; Behavioral; Biological; Biological Specimen Banks; Brain; Cessation of life; Childhood; Clinical; Collaborations; Data; Data Set; Development; Developmental Course; Elderly; Environment; Environmental Risk Factor; Etiology; Family; Family member; Future; Generations; Genes; Genetic; Genetic Predisposition to Disease; Genetic Risk; Genetic study; Genome; Genomics; Goals; Health; Healthcare; Impaired cognition; Individual; Intervention; Life; Link; Longevity; Measures; Mission; Modality; National Institute on Alcohol Abuse and Alcoholism; Nature; Neurobiology; Neurocognitive; Neurons; Neuropsychology; Pathway interactions; Pattern; Persons; Phenotype; Population; Positioning Attribute; Prevention; Preventive Intervention; Public Health; Recording of previous events; Recovery; Relapse; Research; Research Personnel; Risk; Risk Factors; Role; Science; Social Environment; Standardization; Time; Translating; United States; adverse outcome; alcohol consequences; alcohol misuse; alcohol research; alcohol use disorder; base; bench to bedside; burden of illness; clinical care; cognitive development; cost; data management; data sharing; data sharing networks; endophenotype; ethnic diversity; genetics of alcoholism; genome wide association study; genome-wide; high risk; insight; longitudinal course; middle age; neuromechanism; neurophysiology; novel; population health; precision medicine; protective factors; relating to nervous system; repository; resilience; response; social; societal costs; trait; young adult

The Collaborative Study on the Genetics of Alcoholism (COGA) is a tightly integrated and interdisciplinary project, whose overarching goals are to understand the contributions and interactions of genetic, neurobiological, and environmental factors on risk and resilience over the developmental course of AUD, including relapse and recovery. COGA is a family-based study of large, ethnically diverse families, some densely affected by AUD, and family members have been characterized in clinical, behavioral, neuropsychological, neurophysiological, and socio-environmental domains, yielding a rich phenotypic dataset paired with a large repository of biospecimens and genomewide SNP data (GWAS) in 12,145 family members. The breadth and depth of longitudinal assessments in COGA families allow genomic analyses to be conducted within a developmental context, allowing inferences regarding genetic susceptibility and environmental malleability, which may contribute to avenues for prevention and intervention. COGA builds on the key strengths of our research achievements over the past 30 years toward our central mission, to understand the genetics of AUD and its interplay with environment. In response to RFA-AA-19-001, we propose three inter-related and inter-dependent projects (Genomics, Brain Function, Lifespan) supported by 3 essential cores (NIAAA-COGA Sharing Repository (NCSR), Data Management, and Administrative). The projects and cores harness the diverse expertise of the COGA team and the close collaboration among COGA investigators resulting in tight integration and progress toward COGA's goals. Consistent with the RFA and in keeping with COGA's research agenda, the overarching specific aims for the next five years are: Aim 1: Characterize loci, genes, polygenic risk and biological pathways underlying alcohol use and AUDs, and identify the genomic and cellular/neuronal signatures that contribute to alcohol-related phenotypes Aim 2: Advance our understanding of the longitudinal course of alcohol use and AUD, and its adverse outcomes by studying genetic and environmental factors across the lifespan Aim 3: Enhance understanding of brain functioning throughout the course of AUD and recovery, and characterize alcohol related cognitive development and decline in the context of genetic and environmental factors. COGA's multi-pronged approach, long history of productive collaboration among the investigators and commitment to data sharing, will allow us to propel the field of alcohol research towards actionable findings that can be positioned to translate science to population health and clinical care. The gestalt that arises from the integration across COGA's research modalities (genomics, brain function, lifespan) is only possible within a U10 mechanism that supports effective collaboration between researchers with diverse toolkits aimed at addressing the serious public health challenge of AUD.

酒精中毒遗传学的协作性研究是一项紧密结合的交叉学科 该项目的首要目标是了解遗传、神经生物学、 以及环境因素对AUD发展过程中的风险和复原力的影响，包括复发和 恢复。COGA是一项以家庭为基础的研究，对不同种族的大家庭进行研究，其中一些家庭受到澳元疾病的密集影响， 和家庭成员在临床、行为、神经心理、神经生理学和 社会环境领域，产生了丰富的表型数据集和大量的生物标本储存库 和12,145个家庭成员的全基因组SNP数据。纵向的广度和深度 COGA家族的评估允许在发育背景下进行基因组分析， 允许关于遗传易感性和环境延展性的推断，这可能有助于 预防和干预的途径。 COGA以我们过去30年来的研究成果的关键优势为基础，面向我们的 使命，了解澳大利亚糖尿病的遗传学及其与环境的相互作用。响应RFA-AA-19-001， 我们提出了三个相互关联和相互依赖的项目(基因组学、脑功能、寿命)，由 3个基本核心(NIAAA-COGA共享存储库(NCSR)、数据管理和管理)。这个 项目和核心利用COGA团队的不同专业知识以及COGA之间的密切合作 调查人员带来了紧密的整合和朝着COGA目标的进展。与RFA一致，并符合 根据COGA的研究议程，未来五年的总体具体目标是： 目的1：确定饮酒和AUDS的基因座、基因、多基因风险和生物学途径，以及 确定导致酒精相关表型的基因组和细胞/神经元特征 目标2：促进我们对酒精使用和AUD的纵向过程及其不良后果的理解 通过研究生命周期中的遗传和环境因素 目标3：在AUD和康复过程中加强对大脑功能的了解，以及 在遗传和环境的背景下描述与酒精相关的认知发展和衰退 各种因素。 COGA的多管齐下的方法，调查人员和 对数据共享的承诺，将使我们能够推动酒精研究领域走向可操作的发现， 可以定位于将科学转化为人口健康和临床护理。格式塔起源于 COGA的研究模式(基因组学、脑功能、寿命)的集成只能在U10内实现 支持研究人员与旨在解决以下问题的不同工具包进行有效协作的机制 澳元对公共卫生的严峻挑战。