Molecular Pathology and Genomics Core

分子病理学和基因组学核心

基本信息

  • 批准号:
    10005248
  • 负责人:
  • 金额:
    $ 25.18万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-09-01 至 2024-08-31
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY Core C provides access to specialized professional and technical pathology services and genomic services that are essential to the success of the Program. It does so by carrying out 3 overarching aims that support all three P01 Projects: 1) provide pathology expertise needed for classification of primary human PTCLs and PDX and murine PTCL models; 2) perform standard and novel in situ tests for biomarkers relevant to understanding PTCL pathophysiology and its response and resistance to novel therapies; and 3) perform targeted exome sequencing of a large cohort of well-characterized human PTCLs. The Core delivers these services at two performance sites, one in Boston led by Jon Aster, which will deliver services supporting Aims 1 and 2, and the second in North Carolina led by Sandeep Dave, which will deliver services supporting Aims 1 and 3. Delivery of Aim 1 services relies on the Core's co-leader, Dr. Jon Aster, who is a practicing academic hematopathologist with >25 years of experience with human and murine hematopathology, and is supplemented by additional expertise in Project 1 (John Chan) and access to the Hematologic Malignancies Research Consortium, which includes >25 institutions and has accrued over 1800 cases of T cell lymphomas, a majority with paired normal tissue. Aim 2 services will be provided in Boston include standard histology and immunohistology services and innovative, multiparametric immunofluorescence staining platforms, the Perkin- Elmer Vectra platform and CyCIF is an iterative imaging platform that allows for evaluation of >50 different markers on single FFPE slides. Aim 3 services are delivered at the North Carolina performance site by performing targeted exome sequencing on 410 genes that are frequently mutated in lymphoma, initially using DNA prepared from a cohort of 1833 PTCLs and paired normal tissue controls.
项目摘要 核心C提供专业的专业和技术病理学服务和基因组服务 这对该计划的成功至关重要。它通过实现3个总体目标来实现这一目标, 三个P01项目:1)提供原发性人类PTCL和PDX分类所需的病理学专业知识 和鼠PTCL模型; 2)对与理解PTCL相关的生物标志物进行标准和新的原位测试, PTCL病理生理学及其对新疗法的反应和抗性;以及3)进行靶向外显子组 对大量充分表征的人PTCL进行测序。核心提供这些服务, 一个位于波士顿,由乔恩·阿斯特领导,将提供支持目标1和2的服务, 第二个在北卡罗来纳州,由Sandeep Dave领导,将提供支持目标1和3的服务。递送 Aim 1服务的核心依赖于核心的共同领导人Jon Aster博士,他是一位实践学者 具有>25年人类和鼠血液病理学经验的血液病理学家, 补充项目1(John Chan)的额外专业知识,并获得血液肿瘤 研究联盟,其中包括>25个机构,并已累计超过1800例T细胞淋巴瘤, 大多数是成对的正常组织目标2服务将在波士顿提供,包括标准组织学和 免疫组织学服务和创新的多参数免疫荧光染色平台,Perkin- Elmer Vectra平台和CyCIF是一种迭代成像平台,可用于评价>50种不同的 单个FFPE载玻片上的标记。Aim 3服务在北卡罗来纳州的演出现场由 对淋巴瘤中经常突变的410个基因进行靶向外显子组测序,最初使用 从1833例PTCL和配对正常组织对照的队列中制备DNA。

项目成果

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专利数量(0)

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JON C. ASTER其他文献

JON C. ASTER的其他文献

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{{ truncateString('JON C. ASTER', 18)}}的其他基金

Oncopathology Training Program
肿瘤病理学培训计划
  • 批准号:
    10673873
  • 财政年份:
    2020
  • 资助金额:
    $ 25.18万
  • 项目类别:
Oncopathology Training Program
肿瘤病理学培训计划
  • 批准号:
    10459400
  • 财政年份:
    2020
  • 资助金额:
    $ 25.18万
  • 项目类别:
Oncopathology Training Program
肿瘤病理学培训计划
  • 批准号:
    10228052
  • 财政年份:
    2020
  • 资助金额:
    $ 25.18万
  • 项目类别:
Oncopathology Training Program
肿瘤病理学培训计划
  • 批准号:
    10023784
  • 财政年份:
    2020
  • 资助金额:
    $ 25.18万
  • 项目类别:
Molecular Pathology and Genomics Core
分子病理学和基因组学核心
  • 批准号:
    10477052
  • 财政年份:
    2019
  • 资助金额:
    $ 25.18万
  • 项目类别:
Molecular Pathology and Genomics Core
分子病理学和基因组学核心
  • 批准号:
    10673111
  • 财政年份:
    2019
  • 资助金额:
    $ 25.18万
  • 项目类别:
Molecular Pathology and Genomics Core
分子病理学和基因组学核心
  • 批准号:
    10249209
  • 财政年份:
    2019
  • 资助金额:
    $ 25.18万
  • 项目类别:
Molecular Pathology and Genomics Core
分子病理学和基因组学核心
  • 批准号:
    9791872
  • 财政年份:
    2019
  • 资助金额:
    $ 25.18万
  • 项目类别:
Pre-cancer atlases of cutaneous and hematologic origin (PATCH Center)
皮肤和血液来源的癌前图谱(PATCH 中心)
  • 批准号:
    10252281
  • 财政年份:
    2018
  • 资助金额:
    $ 25.18万
  • 项目类别:
CORRELATIVE SCIENCE CORE
相关科学核心
  • 批准号:
    10220874
  • 财政年份:
    2017
  • 资助金额:
    $ 25.18万
  • 项目类别:

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