Molecular Pathology and Genomics Core
分子病理学和基因组学核心
基本信息
- 批准号:10005248
- 负责人:
- 金额:$ 25.18万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-09-01 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:Academic Medical CentersAddressBCL1 OncogeneBCL2 geneBiological MarkersBostonCLIA certifiedCancer CenterCellsCitiesClassificationCollectionColorComplementConsensusDNADana-Farber Cancer InstituteDataData AnalysesDevelopmentDiagnosisDiagnosticEquipmentEvaluationFormalinFunctional disorderGenesGenomicsGenotypeHematologic NeoplasmsHematopathologyHistologyHistopathologyHospitalsHumanIL2RA geneImmuneImmune responseImmunofluorescence ImmunologicIn SituInstitutionInternationalKnowledgeLinkLymphomaMCL1 geneMDM2 geneMedical GeneticsMemorial Sloan-Kettering Cancer CenterModelingMusMutateNormal tissue morphologyNorth CarolinaParaffin EmbeddingPathologicPathologistPathologyPeriodicityPeripheralPrimary NeoplasmProtocols documentationResearchResearch PersonnelResistanceResource SharingResourcesSTAT5B geneSamplingServicesSiteSlideStainsSystemSystems AnalysisT-Cell LymphomaTP53 geneTestingTissue EmbeddingUniversitiesWomanbasecohortdata analysis pipelinedriver mutationexperiencegenomic dataimaging platforminnovationliquid crystal polymermolecular pathologymouse modelneoplastic cellnovelnovel therapeuticsperformance siteprogramsreagent standardresponsesuccesstargeted exome sequencingtherapeutic targettumor microenvironmentweb interfaceweb siteworking group
项目摘要
PROJECT SUMMARY
Core C provides access to specialized professional and technical pathology services and genomic services
that are essential to the success of the Program. It does so by carrying out 3 overarching aims that support all
three P01 Projects: 1) provide pathology expertise needed for classification of primary human PTCLs and PDX
and murine PTCL models; 2) perform standard and novel in situ tests for biomarkers relevant to understanding
PTCL pathophysiology and its response and resistance to novel therapies; and 3) perform targeted exome
sequencing of a large cohort of well-characterized human PTCLs. The Core delivers these services at two
performance sites, one in Boston led by Jon Aster, which will deliver services supporting Aims 1 and 2, and the
second in North Carolina led by Sandeep Dave, which will deliver services supporting Aims 1 and 3. Delivery
of Aim 1 services relies on the Core's co-leader, Dr. Jon Aster, who is a practicing academic
hematopathologist with >25 years of experience with human and murine hematopathology, and is
supplemented by additional expertise in Project 1 (John Chan) and access to the Hematologic Malignancies
Research Consortium, which includes >25 institutions and has accrued over 1800 cases of T cell lymphomas,
a majority with paired normal tissue. Aim 2 services will be provided in Boston include standard histology and
immunohistology services and innovative, multiparametric immunofluorescence staining platforms, the Perkin-
Elmer Vectra platform and CyCIF is an iterative imaging platform that allows for evaluation of >50 different
markers on single FFPE slides. Aim 3 services are delivered at the North Carolina performance site by
performing targeted exome sequencing on 410 genes that are frequently mutated in lymphoma, initially using
DNA prepared from a cohort of 1833 PTCLs and paired normal tissue controls.
项目摘要
核心C提供专业的专业和技术病理学服务和基因组服务
这对该计划的成功至关重要。它通过实现3个总体目标来实现这一目标,
三个P01项目:1)提供原发性人类PTCL和PDX分类所需的病理学专业知识
和鼠PTCL模型; 2)对与理解PTCL相关的生物标志物进行标准和新的原位测试,
PTCL病理生理学及其对新疗法的反应和抗性;以及3)进行靶向外显子组
对大量充分表征的人PTCL进行测序。核心提供这些服务,
一个位于波士顿,由乔恩·阿斯特领导,将提供支持目标1和2的服务,
第二个在北卡罗来纳州,由Sandeep Dave领导,将提供支持目标1和3的服务。递送
Aim 1服务的核心依赖于核心的共同领导人Jon Aster博士,他是一位实践学者
具有>25年人类和鼠血液病理学经验的血液病理学家,
补充项目1(John Chan)的额外专业知识,并获得血液肿瘤
研究联盟,其中包括>25个机构,并已累计超过1800例T细胞淋巴瘤,
大多数是成对的正常组织目标2服务将在波士顿提供,包括标准组织学和
免疫组织学服务和创新的多参数免疫荧光染色平台,Perkin-
Elmer Vectra平台和CyCIF是一种迭代成像平台,可用于评价>50种不同的
单个FFPE载玻片上的标记。Aim 3服务在北卡罗来纳州的演出现场由
对淋巴瘤中经常突变的410个基因进行靶向外显子组测序,最初使用
从1833例PTCL和配对正常组织对照的队列中制备DNA。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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JON C. ASTER其他文献
JON C. ASTER的其他文献
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{{ truncateString('JON C. ASTER', 18)}}的其他基金
Pre-cancer atlases of cutaneous and hematologic origin (PATCH Center)
皮肤和血液来源的癌前图谱(PATCH 中心)
- 批准号:
10252281 - 财政年份:2018
- 资助金额:
$ 25.18万 - 项目类别:
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