Molecular Pathology and Genomics Core
分子病理学和基因组学核心
基本信息
- 批准号:10005248
- 负责人:
- 金额:$ 25.18万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-09-01 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:Academic Medical CentersAddressBCL1 OncogeneBCL2 geneBiological MarkersBostonCLIA certifiedCancer CenterCellsCitiesClassificationCollectionColorComplementConsensusDNADana-Farber Cancer InstituteDataData AnalysesDevelopmentDiagnosisDiagnosticEquipmentEvaluationFormalinFunctional disorderGenesGenomicsGenotypeHematologic NeoplasmsHematopathologyHistologyHistopathologyHospitalsHumanIL2RA geneImmuneImmune responseImmunofluorescence ImmunologicIn SituInstitutionInternationalKnowledgeLinkLymphomaMCL1 geneMDM2 geneMedical GeneticsMemorial Sloan-Kettering Cancer CenterModelingMusMutateNormal tissue morphologyNorth CarolinaParaffin EmbeddingPathologicPathologistPathologyPeriodicityPeripheralPrimary NeoplasmProtocols documentationResearchResearch PersonnelResistanceResource SharingResourcesSTAT5B geneSamplingServicesSiteSlideStainsSystemSystems AnalysisT-Cell LymphomaTP53 geneTestingTissue EmbeddingUniversitiesWomanbasecohortdata analysis pipelinedriver mutationexperiencegenomic dataimaging platforminnovationliquid crystal polymermolecular pathologymouse modelneoplastic cellnovelnovel therapeuticsperformance siteprogramsreagent standardresponsesuccesstargeted exome sequencingtherapeutic targettumor microenvironmentweb interfaceweb siteworking group
项目摘要
PROJECT SUMMARY
Core C provides access to specialized professional and technical pathology services and genomic services
that are essential to the success of the Program. It does so by carrying out 3 overarching aims that support all
three P01 Projects: 1) provide pathology expertise needed for classification of primary human PTCLs and PDX
and murine PTCL models; 2) perform standard and novel in situ tests for biomarkers relevant to understanding
PTCL pathophysiology and its response and resistance to novel therapies; and 3) perform targeted exome
sequencing of a large cohort of well-characterized human PTCLs. The Core delivers these services at two
performance sites, one in Boston led by Jon Aster, which will deliver services supporting Aims 1 and 2, and the
second in North Carolina led by Sandeep Dave, which will deliver services supporting Aims 1 and 3. Delivery
of Aim 1 services relies on the Core's co-leader, Dr. Jon Aster, who is a practicing academic
hematopathologist with >25 years of experience with human and murine hematopathology, and is
supplemented by additional expertise in Project 1 (John Chan) and access to the Hematologic Malignancies
Research Consortium, which includes >25 institutions and has accrued over 1800 cases of T cell lymphomas,
a majority with paired normal tissue. Aim 2 services will be provided in Boston include standard histology and
immunohistology services and innovative, multiparametric immunofluorescence staining platforms, the Perkin-
Elmer Vectra platform and CyCIF is an iterative imaging platform that allows for evaluation of >50 different
markers on single FFPE slides. Aim 3 services are delivered at the North Carolina performance site by
performing targeted exome sequencing on 410 genes that are frequently mutated in lymphoma, initially using
DNA prepared from a cohort of 1833 PTCLs and paired normal tissue controls.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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JON C. ASTER其他文献
JON C. ASTER的其他文献
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{{ truncateString('JON C. ASTER', 18)}}的其他基金
Pre-cancer atlases of cutaneous and hematologic origin (PATCH Center)
皮肤和血液来源的癌前图谱(PATCH 中心)
- 批准号:
10252281 - 财政年份:2018
- 资助金额:
$ 25.18万 - 项目类别:
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