Oncopathology Training Program

肿瘤病理学培训计划

• 批准号: 10673873
• 负责人: JON C. ASTER
• 金额: $ 39.38万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-04 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10673873
• 关键词: Training Programs

PROJECT SUMMARY This is a new application for a Ruth L. Kirschstein National Research Service Award Institutional Research Training Grant (T32) to train post-doctoral trainees in the field of oncopathology, defined broadly as research that seeks to improve our understanding of cancer pathogenesis and pathobiology, and in doing so provide the basis for the development of new approaches that improve cancer diagnosis, prognostication, and treatment. The overall goal of the Oncopathology Training Program (OTP) is to provide research training opportunities across the full spectrum of oncopathology research, from basic study of cancer pathogenesis using the tools of cell and molecular biology, genomics, proteomics, animal modeling, and bioinformatics, to translational research that involves the development and deployment of biomarker tests and the use of digital and computational pathology, approaches that are increasingly important in cancer research. The training program is designed to benefit the research career development of M.D. and M.D./Ph.D. trainees subsequent to their training in clinical and/or anatomic pathology, and Ph.D. trainees with educational backgrounds in computational fields interested in the emerging area of computational pathology. Support is requested for 4 postdoctoral trainees in years 1-2, and 5 trainees in years 3-5. The training program includes structured elements such as individual development plans, mentored research experiences, and customizable didactic training opportunities as well as workshops in grant writing, manuscript composition, and lab management. Each trainee will have Postdoctoral Advisory Committee comprised of the Program Director, primary research mentor, and one or more senior cancer researchers with relevant expertise that will review trainee progress, provide advice and constructive criticism, and serve as a review committee for external fellowship proposals. The OTP faculty includes 24 highly accomplished investigators, with extensive mentoring track records and substantial extramural grant support, who constitute a highly collaborative mentoring community whose expertise span a wide-range of multidisciplinary, oncopathology-relevant areas, including animal modeling of cancer, cancer immunology, cancer genomics, computational pathology and tissue imaging, cancer diagnostics, and translational cancer informatics. The OTP will also take advantage of the extensive complement of scientific and educational resources that are available at Brigham and Women’s Hospital (BWH), Harvard Medical School (HMS). and Dana Farber Cancer Institute (DFCI), including the NCI-funded Dana-Farber/Harvard Cancer Center.

项目摘要 这是一个叫露丝·L的人的新申请Kirschstein国家研究服务奖机构研究 培训补助金（T32），用于培训肿瘤病理学领域的博士后学员，广义上定义为研究 旨在提高我们对癌症发病机制和病理生物学的理解，并在此过程中提供 这是开发新方法的基础，可改善癌症的诊断、诊断和治疗。 肿瘤病理学培训计划（OTP）的总体目标是提供研究培训机会 在肿瘤病理学研究的全方位，从使用工具的癌症发病机制的基础研究， 细胞和分子生物学、基因组学、蛋白质组学、动物建模和生物信息学， 涉及生物标志物测试的开发和部署以及数字和 计算病理学，在癌症研究中越来越重要的方法。培训计划 旨在促进医学博士的研究生涯发展。M.D.博士受训人员在 临床和/或解剖病理学培训，以及博士学位有教育背景的受训人员， 对计算病理学的新兴领域感兴趣的计算领域。请求支助4 1-2年博士后培训生，3-5年5名培训生。培训计划包括结构化 个人发展计划，指导研究经验和可定制的教学等要素 培训机会，以及在赠款写作，手稿组成，和实验室管理讲习班。 每个实习生将有博士后咨询委员会组成的项目主任，主要研究 导师，以及一名或多名具有相关专业知识的高级癌症研究人员，将审查学员的进展， 提供咨询意见和建设性批评，并担任外部研究金提案的审查委员会。 检察官办公室的教员包括24名非常有成就的调查员，他们有着广泛的指导记录， 大量的校外赠款支持，他们构成了一个高度协作的指导社区， 专业知识涵盖广泛的多学科，肿瘤病理学相关领域，包括动物模型， 癌症，癌症免疫学，癌症基因组学，计算病理学和组织成像，癌症 诊断学和翻译癌症信息学。检察官办公室还将利用广泛的 布里格姆妇女医院现有的科学和教育资源的补充 (BWH)、哈佛医学院（HMS）。和达纳法伯癌症研究所（DFCI），包括NCI资助的 丹娜-法伯/哈佛癌症中心。

项目成果

The Immunophenotypic Profile of Healthy Human Bone Marrow.

• DOI: 10.1016/j.cll.2023.04.003
• 发表时间: 2023-06
• 期刊: Clinics in laboratory medicine
• 影响因子: 1.7
• 作者: J. Lewis;C. Hergott

Clinical Trial-Ready Patient Cohorts for Multiple System Atrophy: Coupling Biospecimen and iPSC Banking to Longitudinal Deep-Phenotyping.

• DOI: 10.1007/s12311-022-01471-8
• 发表时间: 2024-02
• 期刊: Cerebellum (London, England)

Artificial intelligence for multimodal data integration in oncology.

• DOI: 10.1016/j.ccell.2022.09.012
• 发表时间: 2022-10-10
• 期刊: CANCER CELL
• 影响因子: 50.3
• 作者: Lipkova, Jana;Chen, Richard J.;Chen, Bowen;Lu, Ming Y.;Barbieri, Matteo;Shao, Daniel;Vaidya, Anurag J.;Chen, Chengkuan;Zhuang, Luoting;Williamson, Drew F. K.;Shaban, Muhammad;Chen, Tiffany Y.;Mahmood, Faisal
• 通讯作者: Mahmood, Faisal

Role of condensates in modulating DNA repair pathways and its implication for chemoresistance.

• DOI: 10.1016/j.jbc.2023.104800
• 发表时间: 2023-06
• 期刊: JOURNAL OF BIOLOGICAL CHEMISTRY
• 影响因子: 4.8
• 作者: Dall'Agnese, Giuseppe;Dall'Agnese, Alessandra;Banani, Salman F.;Codrich, Marta;Malfatti, Matilde Clarissa;Antoniali, Giulia;Tell, Gianluca
• 通讯作者: Tell, Gianluca

Algorithmic fairness in artificial intelligence for medicine and healthcare.

• DOI: 10.1038/s41551-023-01056-8
• 发表时间: 2023-06
• 期刊: Nature biomedical engineering
• 影响因子: 28.1