Core D: Neuroimaging Core
Core D: Neuroimaging Core
批准号:
10037879
负责人:
Bradley T Christian
金额:
$209.8万
依托单位国家:
美国
项目类别:
财政年份:
2020
资助国家:
美国
项目状态:
未结题
起止时间:
2020-09-30 至 2025-08-31
关键词:
AddressAdultAlzheimer&aposs DiseaseAlzheimer&aposs disease modelAlzheimer’s disease biomarkerAmyloidAnatomyAttenuatedBiologicalBiological MarkersBrainBrain regionCerebrovascular CirculationCerebrovascular DisordersClinicalCommunitiesDataData SourcesDatabasesDementiaDiffusion Magnetic Resonance ImagingDown SyndromeFunctional Magnetic Resonance ImagingGeneral PopulationGenomicsGlucoseGoalsImageInfarctionInfrastructureInheritedInvestigationLaboratoriesLiquid substanceMagnetic Resonance ImagingMeasurementMeasuresMindModalityNerve DegenerationOutcomeOutcome MeasurePathologicPittsburgh Compound-BPopulationPositron-Emission TomographyProcessProtocols documentationQuality ControlRecoveryResearch PersonnelResolutionResourcesRestRisk FactorsScanningSiteSpin LabelsStandardizationStatistical Data InterpretationStructureStudy of magneticsSymptomsTechniquesThickWhite Matter HyperintensityWorkbaseblood oxygen level dependentcerebrovasculardata accessdesignfluorodeoxyglucosefluorodeoxyglucose positron emission tomographyglucose metabolismimaging modalityinsightinterestmetabolic rateneuroimagingneuroimaging markerperformance siteprecision medicineprimary outcometau Proteinswhite matter
中文摘要
神经影像核心摘要
由Adam Brickman博士和Brad Christian博士领导的ABC-DS神经成像核心将应用最先进的技术
正电子发射断层扫描(PET)和磁共振成像(MRI)神经成像技术
唐氏综合征(DS)患者淀粉样蛋白、tau蛋白和神经退行性变(AT(N))的定量
阿尔茨海默病(AD)的病理生理模型及其相关脑血管,微结构,
和功能性生物标记物。神经成像核心的具体目标是:(1)监督协调
获取8个临床表现部位的PET和MRI数据;(2)量化主要结果
每种神经成像模式的测量;(3)将处理后的神经成像数据集成到ABC-DS中
支持拟议项目的数据库;和(4)提供经过管理的主要成果变量和原始数据
将神经成像数据提供给更广泛的科学界。整体扫描方案将遵循已开发的方案
由阿尔茨海默病神经成像倡议(ADNI)为MRI(结构和功能)和PET(淀粉样蛋白,
Tau,FDG)。结果变量由特定于医疗模式的分析节点导出,并对每种医疗模式进行分析
由一个在神经成像生物标记物方面拥有专业知识的实验室。核心将利用NIA赞助的
目前支持正在进行的大规模AD神经成像计划的资源(例如ADNI、Dominly
遗传性阿尔茨海默病网络(DIAN)),以提供完全开发的数据访问管道,鼓励科学
DS神经影像生物标志物的研究。
英文摘要
Neuroimaging Core Abstract
The ABC-DS Neuroimaging Core, led by Drs. Adam Brickman and Brad Christian, will apply state-of-the art
positron emission tomography (PET) and magnetic resonance imaging (MRI) neuroimaging techniques to
quantitate amyloid, tau, and neurodegeneration (AT(N)) in Down syndrome (DS) according to current
pathophysiological models of Alzheimer’s disease (AD) together with related cerebrovascular, microstructural,
and functional biomarkers. The specific aims of the Neuroimaging Core are to: (1) oversee the harmonized
acquisition of PET and MRI data at each of the 8 clinical performance sites; (2) quantitate primary outcome
measures for each neuroimaging modality; (3) integrate the processed neuroimaging data into a ABC-DS
database to support the proposed projects; and (4) provide curated primary outcome variables and raw
neuroimaging data to the wider scientific community. The overall scanning protocols will follow those developed
by the Alzheimer’s Disease Neuroimaging Initiative (ADNI) for MRI (structural and functional) and PET (amyloid,
tau, FDG). The outcome variables are derived by modality-specific analytic nodes, with each modality analyzed
by a single laboratory with expertise in that neuroimaging biomarker. The Core will utilize NIA-sponsored
resources that currently support ongoing large-scale AD neuroimaging initiatives (e.g. ADNI, Dominantly
Inherited Alzheimer Network (DIAN)) to provide a fully developed data-access pipeline that encourages scientific
investigation of neuroimaging biomarkers in DS.
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专著(0)
科研奖励(0)
会议论文
Core D: Neuroimaging Core
-
批准号:10454255
-
项目类别:
-
资助金额:$432.65万
-
财政年份:2020
-
负责人:Bradley T Christian
-
依托单位:
Core D: Neuroimaging Core
-
批准号:10667576
-
项目类别:
-
资助金额:$665.08万
-
财政年份:2020
-
负责人:Bradley T Christian
-
依托单位:
Alzheimer Biomarker Consortium - Down Syndrome (ABC-DS) - Supplement
-
批准号:10833788
-
项目类别:
-
资助金额:$43.88万
-
财政年份:2020
-
负责人:Bradley T Christian
-
依托单位:
Alzheimer Biomarker Consortium - Down Syndrome (ABC-DS)
-
批准号:10037875
-
项目类别:
-
资助金额:$2098.04万
-
财政年份:2020
-
负责人:Bradley T Christian
-
依托单位:
ABC-DS MOMs’ Supplement (Modification of Maternal AD risk in DS)
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批准号:10595165
-
项目类别:
-
资助金额:$78.87万
-
财政年份:2020
-
负责人:Bradley T Christian
-
依托单位:
Alzheimer Biomarker Consortium - Down Syndrome (ABC-DS)
-
批准号:10667549
-
项目类别:
-
资助金额:$2177.65万
-
财政年份:2020
-
负责人:Bradley T Christian
-
依托单位:
Alzheimer Biomarker Consortium - Down Syndrome (ABC-DS)
-
批准号:10264834
-
项目类别:
-
资助金额:$1935.51万
-
财政年份:2020
-
负责人:Bradley T Christian
-
依托单位:
Alzheimer Biomarker Consortium - Down Syndrome (ABC-DS)
-
批准号:10454250
-
项目类别:
-
资助金额:$1923.36万
-
财政年份:2020
-
负责人:Bradley T Christian
-
依托单位:
Alzheimer Biomarker Consortium - Down Syndrome (ABC-DS) - KUMC Field Site Supplement
-
批准号:10844809
-
项目类别:
-
资助金额:$77.49万
-
财政年份:2020
-
负责人:Bradley T Christian
-
依托单位:
Alzheimer Biomarker Consortium - Down Syndrome (ABC-DS)-04 Supplement 5
-
批准号:10665185
-
项目类别:
-
资助金额:$76.53万
-
财政年份:2020
-
负责人:Bradley T Christian
-
依托单位:
Core D: Neuroimaging Core
-
批准号:10264838
-
项目类别:
-
资助金额:$425.11万
-
财政年份:2020
-
负责人:Bradley T Christian
-
依托单位:
Neurodegeneration in Aging Down Syndrome (NiAD): A Longitudinal Study of Cognition and Biomarkers of Alzheimer's Disease
-
批准号:9743344
-
项目类别:
-
资助金额:$6.99万
-
财政年份:2015
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负责人:Bradley T Christian
-
依托单位:
Neurodegeneration in Aging Down Syndrome (NiAD): A Longitudinal Study of Cognition and Biomarkers of Alzheimer's Disease
-
批准号:9146760
-
项目类别:
-
资助金额:$355.69万
-
财政年份:2015
-
负责人:Bradley T Christian
-
依托单位:
[F-18]Mefway PET to measure 5-HT1A receptors in gene x environment interactions
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批准号:7835573
-
项目类别:
-
资助金额:$21.89万
-
财政年份:2009
-
负责人:Bradley T Christian
-
依托单位:
[F-18]Mefway PET to measure 5-HT1A receptors in gene x environment interactions
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批准号:7639993
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项目类别:
-
资助金额:$18.17万
-
财政年份:2009
-
负责人:Bradley T Christian
-
依托单位:
A novel PET radiotracer to study 5HT-1A receptors in fetal alcohol exposure
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批准号:7510115
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项目类别:
-
资助金额:$7.43万
-
财政年份:2008
-
负责人:Bradley T Christian
-
依托单位:
A novel PET radiotracer to study 5HT-1A receptors in fetal alcohol exposure
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批准号:7688167
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项目类别:
-
资助金额:$7.43万
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财政年份:2008
-
负责人:Bradley T Christian
-
依托单位:
PET Imaging agents for a4b2 Nicotinic Receptors
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批准号:10060568
-
项目类别:
-
资助金额:$24.91万
-
财政年份:2007
-
负责人:Bradley T Christian
-
依托单位:
海外基金