Promoting Cervical Cancer Screening among African American and Sub-Saharan African Immigrant women

促进非裔美国人和撒哈拉以南非洲移民妇女的宫颈癌筛查

• 批准号: 10038650
• 负责人: Adebola O Adegboyega
• 金额: $ 15.34万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-02 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10038650
• 关键词: Address; Africa South of the Sahara; African; African American; Awareness; Behavior Therapy; Belief; Cancer Control; Cancer Etiology; Central Asia; Cervical; Cervical Cancer Screening; Cessation of life; Clinic Visits; Clinical Trials Design; Collection; Consent; Cross-Sectional Studies; Data; Death Rate; Developing Countries; Development; Development Plans; Diagnosis; Education; Emotional; Environment; Evidence based intervention; Experimental Designs; Extramural Activities; Frequencies; Fright; Funding; Future; Geographic Locations; Goals; Health; Health Promotion; Health education; Healthcare Systems; Human Papillomavirus; Human papilloma virus infection; Immigrant; Incidence; Individual; Intervention; Intervention Studies; Irrigation; K-Series Research Career Programs; Kentucky; Knowledge; Lesion; Literature; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Mentored Research Scientist Development Award; Mentors; Methods; Minority; Modality; Modeling; Not Hispanic or Latino; Outcome; Outcome Measure; Pattern; Physicians; Population; Population Heterogeneity; Population Study; Prevention; Privatization; Quality of Care; Race; Randomized Clinical Trials; Research; Research Personnel; Research Training; Resources; Role; Sampling; Screening for cancer; Screening procedure; Self Efficacy; Sensitivity and Specificity; South America; Structure; Subgroup; Swab; Testing; Time; Training; Treatment Efficacy; Underserved Population; United States; Universities; Vaccination; Visit; Vulnerable Populations; Woman; aged; anticancer research; behavior change; behavior influence; black subgroup; cancer health disparity; cancer prevention; career; career development; cervical cancer prevention; cost; evidence base; experience; health belief; health care availability; health knowledge; high risk; high risk population; innovation; intervention effect; men; mortality; peer; prevent; programs; prophylactic; racial and ethnic disparities; recruit; research study; satisfaction; screening; screening participation; skills; social; social cognitive theory; underserved minority; willingness

‐ PROJECT SUMMARY/ABSTRACT The highest incidence rates of cervical cancer (CC) are in sub-Saharan Africa, South Central Asia and South America. In the United States (U.S.), CC ranks 14th in frequency. However, in certain populations and geographic areas of the U.S., CC incidence and death rates are significantly higher, due in part to racial and ethnic disparities in access, utilization, and quality of care, all of which contribute to worse health outcomes. Black women experience a disparate burden of CC incidence and mortality, having a higher risk of being diagnosed with and dying from CC than non-Hispanic White women. Appropriate and timely CC screening is a key factor in prevention. Leveraging the positive benefits of CC screening may reduce the CC disparate burden among Blacks. Research studies typically treat Blacks as a homogeneous group, despite differences within this population. To begin to address a gap in the literature within the scope of a career development award, this study focuses specifically on two subgroups of Black women - African Americans (AA) and Sub-Saharan African immigrants (SAI) given that there is paucity of research with SAI despite known cancer related disparities among SAI women. To promote screening for these underserved minority women, we will conduct research to better understand factors that influence engagement in cancer screening practices and willingness to conduct HPV self-sampling in which women self-collect samples for HPV testing using a swab, brush or lavage. Guided by the findings, we will develop and pilot test an innovative tailored intervention incorporating HPV self-sampling with peer-delivered education. The specific aims are to (1) examine general awareness and cultural factors related to cancer control and prevention among AA and SAIs; (2) examine the socioecological barriers and facilitators to CC screening with HPV self-sampling to tailor an evidenced based cervical health promotion program in these underserved subgroups; and (3) assess feasibility, acceptability, and preliminary efficacy of the intervention. The intervention, entitled Health is Wealth: A Cervical Health Program, will be pilot tested with 30 AA and 30 SAI women aged 30 to 65 years using a quasi-experimental design. These aims will also support the candidate’s career goal of developing an independent and extramurally funded program of research to promote cancer control and prevention for minority women. To further support this goal, a mentored career development plan consisting of training in mixed methods, adaptation and development of behavioral interventions, randomized clinical trial design, and research team management, is proposed. The rich research environment at the University of Kentucky and the expertise of the mentoring team will provide the supplemental resources and support needed for the candidate to successfully complete the proposed research and training plans. As such, this K01 award will provide the training, mentoring, and research experiences needed for the candidate to successfully compete for a R01-level CC screening intervention study and expedite her career development.

‐ 项目总结/摘要 宫颈癌（CC）的发病率最高的地区是撒哈拉以南非洲，南亚和南亚。 美国参考在美国（U.S.），CC在频率上排名第14位。然而，在某些人群和地理 美国的一些地区，CC的发病率和死亡率明显较高，部分原因是种族和民族差异 在获得、利用和护理质量方面，所有这些都导致了更糟糕的健康结果。黑人女性 经历不同的CC发病率和死亡率负担，具有较高的被诊断为 死于CC比非西班牙裔白色妇女。适当和及时的CC筛查是 预防利用CC筛查的积极益处可以减少CC之间的不同负担， 黑人研究通常将黑人视为一个同质的群体，尽管这一群体内部存在差异。 人口为了开始解决职业发展奖范围内文献中的空白， 研究特别关注黑人女性的两个亚群--非裔美国人（AA）和撒哈拉以南非洲人 鉴于SAI的研究很少，尽管已知与癌症相关的差异， 最高审计署的妇女。为了促进对这些服务不足的少数民族妇女的筛查，我们将进行研究， 了解影响参与癌症筛查实践和进行HPV检查意愿的因素 自我采样，女性使用拭子、刷子或灌洗自行采集样本进行HPV检测。为指导 研究结果，我们将开发和试点测试一种创新的量身定制的干预措施，包括HPV自我采样， 同伴教育具体目的是（1）考察一般意识和相关的文化因素 癌症控制和预防的AA和SAIs;（2）检查社会生态障碍和促进因素， CC筛查与HPV自我采样，以定制基于证据的宫颈健康促进计划， 服务不足的亚组;（3）评估干预的可行性，可接受性和初步疗效。的 名为“健康就是财富：宫颈健康计划”的干预措施将在30名AA和30名SAI中进行试点测试 年龄在30 - 65岁之间的女性，采用准实验设计。这些目标也将支持候选人的 发展一个独立的和校外资助的研究计划，以促进癌症的职业目标 控制和预防少数民族妇女。为了进一步支持这一目标， 包括混合方法的培训，行为干预的适应和发展，随机 临床试验设计和研究团队管理。丰富的研究环境， 肯塔基州大学和指导团队的专业知识将提供补充资源和 候选人成功完成拟议的研究和培训计划所需的支持。因此，在本发明的一个方面， 该K 01奖将为候选人提供所需的培训、指导和研究经验， 成功竞争R 01级CC筛查干预研究并加快其职业发展。