A biomimetic strategy to treat enamel loss

治疗牙釉质缺失的仿生策略

基本信息

  • 批准号:
    10042609
  • 负责人:
  • 金额:
    $ 29.85万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-09-09 至 2022-08-31
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY There is an unmet need for an agent that accelerates the growth of newly formed mineral with sufficient density, purity, and bonding to the underlying tooth crown. The long-term goal is to develop a biologically inspired strategy to treat enamel loss through leveraging and amplifying the naturally occurring mineralization in the oral cavity. The objective in this application, therefore, is to a) optimize the effectiveness of the 8DSS peptide for accelerating controlled mineralization of enamel and b) to develop strategies for the control of 8DSS activity by modification of the local oral environment. The central hypothesis, based on the research team's strong preliminary data, is that using a biologically inspired approach, 8DSS peptide sufficiently accelerates the regeneration of enamel with appropriate attachment, structure and mechanical properties, and achieves clinical relevance. The rationale for these studies is that based on the effectiveness and shared characteristics of calcium and hydroxyapatite-binding proteins that facilitate mineralization in bone and teeth. Specifically, the negative charge and phosphorylation of aspartate-serine-serine (DSS) sequence repeats as seen in human dentin phosphoprotein (DPP) is known to promote the formation of hydroxyapatite. The research team plans to objectively test the central hypothesis and achieve the objective by pursuing the following two Specific Aims: 1) Test in vitro 8DSS application on human teeth for a) remineralization of demineralized enamel and b) regeneration of enamel surfaces, and 2) Test in vitro that 8DSS activity can be controlled by variations in local conditions. The contribution here is expected to be an expansion of our preliminary studies to enhance the effectiveness of the 8DSS peptide for accelerating controlled mineralization of enamel and develop strategies for the controlled inactivation, or removal of 8DSS from newly formed mineral. This contribution will be significant because the mechanism of 8DSS achieving biomimetic remineralization remains unclear and the major hurdle preventing clinical use is the controlled 8DSS activation and deactivation, or removal from the newly formed tissue to achieve the low protein content and high mineral density as in healthy enamel. The proposed research is innovative, because as it departs from the status quo by leveraging and amplifying the naturally occurring mineralization in the oral cavity.
项目总结

项目成果

期刊论文数量(0)
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Felicitas B Bidlack其他文献

Felicitas B Bidlack的其他文献

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{{ truncateString('Felicitas B Bidlack', 18)}}的其他基金

Caries resistance mechanisms in high-risk Indigenous children
高危原住民儿童的防龋机制
  • 批准号:
    10639704
  • 财政年份:
    2023
  • 资助金额:
    $ 29.85万
  • 项目类别:
What gives the dentin-enamel junction strength? Structural and mechanical function of collagen and amelogenin.
是什么赋予牙本质-牙釉质连接强度?
  • 批准号:
    10117223
  • 财政年份:
    2020
  • 资助金额:
    $ 29.85万
  • 项目类别:
A biomimetic strategy to treat enamel loss
治疗牙釉质缺失的仿生策略
  • 批准号:
    10259677
  • 财政年份:
    2020
  • 资助金额:
    $ 29.85万
  • 项目类别:
Saliva-mediated Mechanisms of Post-Eruptive Enamel Mineralization
唾液介导的牙釉质矿化后机制
  • 批准号:
    9456300
  • 财政年份:
    2018
  • 资助金额:
    $ 29.85万
  • 项目类别:
Enamel matrix 3D organization and maturation stage ion flow
牙釉质基质 3D 组织和成熟阶段离子流
  • 批准号:
    9304187
  • 财政年份:
    2016
  • 资助金额:
    $ 29.85万
  • 项目类别:
Protein-Mineral Interactions During Initial Stages of Enamel Formation
牙釉质形成初始阶段的蛋白质-矿物质相互作用
  • 批准号:
    8244215
  • 财政年份:
    2012
  • 资助金额:
    $ 29.85万
  • 项目类别:
Protein-Mineral Interactions During Initial Stages of Enamel Formation
牙釉质形成初始阶段的蛋白质-矿物质相互作用
  • 批准号:
    8435404
  • 财政年份:
    2012
  • 资助金额:
    $ 29.85万
  • 项目类别:

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