A biomimetic strategy to treat enamel loss

治疗牙釉质缺失的仿生策略

基本信息

  • 批准号:
    10259677
  • 负责人:
  • 金额:
    $ 24.88万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-09-09 至 2023-08-31
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY There is an unmet need for an agent that accelerates the growth of newly formed mineral with sufficient density, purity, and bonding to the underlying tooth crown. The long-term goal is to develop a biologically inspired strategy to treat enamel loss through leveraging and amplifying the naturally occurring mineralization in the oral cavity. The objective in this application, therefore, is to a) optimize the effectiveness of the 8DSS peptide for accelerating controlled mineralization of enamel and b) to develop strategies for the control of 8DSS activity by modification of the local oral environment. The central hypothesis, based on the research team's strong preliminary data, is that using a biologically inspired approach, 8DSS peptide sufficiently accelerates the regeneration of enamel with appropriate attachment, structure and mechanical properties, and achieves clinical relevance. The rationale for these studies is that based on the effectiveness and shared characteristics of calcium and hydroxyapatite-binding proteins that facilitate mineralization in bone and teeth. Specifically, the negative charge and phosphorylation of aspartate-serine-serine (DSS) sequence repeats as seen in human dentin phosphoprotein (DPP) is known to promote the formation of hydroxyapatite. The research team plans to objectively test the central hypothesis and achieve the objective by pursuing the following two Specific Aims: 1) Test in vitro 8DSS application on human teeth for a) remineralization of demineralized enamel and b) regeneration of enamel surfaces, and 2) Test in vitro that 8DSS activity can be controlled by variations in local conditions. The contribution here is expected to be an expansion of our preliminary studies to enhance the effectiveness of the 8DSS peptide for accelerating controlled mineralization of enamel and develop strategies for the controlled inactivation, or removal of 8DSS from newly formed mineral. This contribution will be significant because the mechanism of 8DSS achieving biomimetic remineralization remains unclear and the major hurdle preventing clinical use is the controlled 8DSS activation and deactivation, or removal from the newly formed tissue to achieve the low protein content and high mineral density as in healthy enamel. The proposed research is innovative, because as it departs from the status quo by leveraging and amplifying the naturally occurring mineralization in the oral cavity.
项目总结 对一种能够加速新形成的矿物生长的试剂的需求还没有得到满足,这种矿物具有足够的 密度、纯度和与底层牙冠的粘合力。长期目标是发展出一种生物学上的 通过利用和放大自然矿化来治疗釉质流失的创新策略 在口腔里。因此,该应用程序的目标是a)优化8DSS的有效性 促进牙釉质受控矿化的多肽和b)制定控制牙釉质矿化的策略 8DSS活性可通过改变局部口腔环境来实现。基于这项研究的中心假设 团队强有力的初步数据是,使用生物启发的方法,8DSS多肽足够 通过适当的附着性、结构和机械性能加速牙釉质的再生 达到临床应用的目的。这些研究的基本原理是基于有效性和共享 促进骨骼和牙齿矿化的钙和羟基磷灰石结合蛋白的特征。 具体来说,天冬氨酸-丝氨酸-丝氨酸(DSS)序列的负电荷和磷酸化重复如下 在人牙本质中发现的磷蛋白(DPP)被认为可以促进羟基磷灰石的形成。这个 研究小组计划客观地检验中心假说,并通过追求 以下两个具体目标:1)在体外测试8DSS在人类牙齿上的应用a)再矿化 脱矿牙釉质和b)牙釉质表面的再生,以及2)体外测试8DSS活性可以 受当地条件变化的控制。预计这里的贡献将是我们的扩展 提高8DSS多肽促进控矿效果的初步研究 并制定策略,控制新形成的牙釉质中8DSS的失活或去除 矿物。这一贡献将是重大的,因为8DSS实现仿生的机制 再矿化尚不清楚,阻碍临床应用的主要障碍是受控的8DSS激活 和失活,或从新形成的组织中移除,以实现低蛋白质含量和高矿物质含量 密度与健康牙釉质相同。这项拟议的研究具有创新性,因为它偏离了现状 通过利用和放大口腔中自然发生的矿化作用。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Felicitas B Bidlack其他文献

Felicitas B Bidlack的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Felicitas B Bidlack', 18)}}的其他基金

Caries resistance mechanisms in high-risk Indigenous children
高危原住民儿童的防龋机制
  • 批准号:
    10639704
  • 财政年份:
    2023
  • 资助金额:
    $ 24.88万
  • 项目类别:
What gives the dentin-enamel junction strength? Structural and mechanical function of collagen and amelogenin.
是什么赋予牙本质-牙釉质连接强度?
  • 批准号:
    10117223
  • 财政年份:
    2020
  • 资助金额:
    $ 24.88万
  • 项目类别:
A biomimetic strategy to treat enamel loss
治疗牙釉质缺失的仿生策略
  • 批准号:
    10042609
  • 财政年份:
    2020
  • 资助金额:
    $ 24.88万
  • 项目类别:
Saliva-mediated Mechanisms of Post-Eruptive Enamel Mineralization
唾液介导的牙釉质矿化后机制
  • 批准号:
    9456300
  • 财政年份:
    2018
  • 资助金额:
    $ 24.88万
  • 项目类别:
Enamel matrix 3D organization and maturation stage ion flow
牙釉质基质 3D 组织和成熟阶段离子流
  • 批准号:
    9304187
  • 财政年份:
    2016
  • 资助金额:
    $ 24.88万
  • 项目类别:
Protein-Mineral Interactions During Initial Stages of Enamel Formation
牙釉质形成初始阶段的蛋白质-矿物质相互作用
  • 批准号:
    8244215
  • 财政年份:
    2012
  • 资助金额:
    $ 24.88万
  • 项目类别:
Protein-Mineral Interactions During Initial Stages of Enamel Formation
牙釉质形成初始阶段的蛋白质-矿物质相互作用
  • 批准号:
    8435404
  • 财政年份:
    2012
  • 资助金额:
    $ 24.88万
  • 项目类别:

相似海外基金

Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
  • 批准号:
    MR/S03398X/2
  • 财政年份:
    2024
  • 资助金额:
    $ 24.88万
  • 项目类别:
    Fellowship
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
  • 批准号:
    2338423
  • 财政年份:
    2024
  • 资助金额:
    $ 24.88万
  • 项目类别:
    Continuing Grant
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
  • 批准号:
    EP/Y001486/1
  • 财政年份:
    2024
  • 资助金额:
    $ 24.88万
  • 项目类别:
    Research Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
  • 批准号:
    MR/X03657X/1
  • 财政年份:
    2024
  • 资助金额:
    $ 24.88万
  • 项目类别:
    Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
  • 批准号:
    2348066
  • 财政年份:
    2024
  • 资助金额:
    $ 24.88万
  • 项目类别:
    Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
  • 批准号:
    AH/Z505481/1
  • 财政年份:
    2024
  • 资助金额:
    $ 24.88万
  • 项目类别:
    Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10107647
  • 财政年份:
    2024
  • 资助金额:
    $ 24.88万
  • 项目类别:
    EU-Funded
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
  • 批准号:
    2341402
  • 财政年份:
    2024
  • 资助金额:
    $ 24.88万
  • 项目类别:
    Standard Grant
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10106221
  • 财政年份:
    2024
  • 资助金额:
    $ 24.88万
  • 项目类别:
    EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
  • 批准号:
    AH/Z505341/1
  • 财政年份:
    2024
  • 资助金额:
    $ 24.88万
  • 项目类别:
    Research Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了