Midcareer Mentoring in Patient-Oriented Research on Genitourinary Aging in Women

以患者为导向的女性泌尿生殖系统衰老研究中的职业生涯中期指导

• 批准号: 10040999
• 负责人: Alison Huang
• 金额: $ 19.35万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10040999
• 关键词: Address; Age; Aging; Anxiety; Atrophic; Award; Behavior Therapy; Behavioral; Bladder; Bladder Control; Clinical; Clinical Investigator; Clinical Treatment; Clinical Trials; Communities; Complement; Complex; Defect; Development; Diagnostic; Educational workshop; Elderly; Environment; Equilibrium; Evaluation; Female; Fibrinogen; Frequencies; Functional disorder; Funding; Genitourinary system; Goals; Health; Health behavior; Impaired cognition; Incontinence; Infrastructure; Injections; Institutes; International; Internist; Intervention; Intervention Studies; Intervention Trial; Leadership; Measures; Mediating; Menopausal Symptom; Menopause; Mental Depression; Mentors; Mentorship; Mid-Career Clinical Scientist Award (K24); Modeling; Muscle; National Institute on Aging; Nocturia; Observational Study; Organ; Outcome; Outcome Measure; Patient Outcomes Assessments; Patient Self-Report; Pelvic floor dysfunction; Pelvic floor structure; Performance Status; Pharmaceutical Preparations; Physical Function; Physical Performance; Physical activity; Physiology; Population; Positioning Attribute; Prevention; Prevention strategy; Psyche structure; Public Health; Publishing; Quality of life; Research; Research Personnel; Research Project Grants; Research Training; Risk; Risk Factors; Role; Scientific Advances and Accomplishments; Series; Severities; Sleep; Sleep disturbances; Stress; Stretching; Structure; Symptoms; Syndrome; Testing; Therapeutic; Training; Training Programs; United States National Institutes of Health; Urinary Incontinence; Vagina; Woman; Women' s Health; Work; Yoga; base; bladder surgery; botulinum; career development; cost; data warehouse; design; diaries; experience; feasibility trial; improved; incontinence symptom; interest; intervention effect; mental function; older women; patient oriented research; perceived stress; performance status 2; pilot trial; pleiotropism; programs; prospective; psychologic; psychological distress; randomized trial; recruit; response; sleep quality; synergism; treatment response; treatment strategy; urinary; urologic

PROJECT SUMMARY This application for a K24 Midcareer Investigator Award will promote Dr. Alison Huang’s mentoring and career development in patient-oriented research on genitourinary aging in women. Dr. Huang is a general internist and women’s health investigator dedicated to advancing scientific understanding and improving management of the impact of aging on women’s health, especially genitourinary health. With funding from the National Institute on Aging and other NIH institutes/centers, she leads a nationally recognized, patient- oriented research program that emphasizes shared factors underlying aging-associated genitourinary dysfunction and other common aging syndromes such as physical function decline, cognitive decline, depression and anxiety, and sleep disruption. Her work to date has created new patient-reported outcome measures used in national and international studies of genitourinary health in older women and provided new evidence to guide diagnostic and treatment strategies for conditions such as urinary incontinence, urogenital atrophy, nocturia, and menopausal symptoms. She has also emerged as a successful mentor of junior clinicians who have published high-impact research, obtained federally funded research awards, and continued to participate in patient-oriented research on older women’s health. Currently there are no K24 awards from the National Institute on Aging that support mentorship for research on genitourinary aging in women or on older women’s health broadly. As a result, Dr. Huang seeks support to expand her mentoring of diverse clinical trainees interested in studying genitourinary health and function in older women as well as the impact of aging and menopause on older women’s health. She will leverage past and current research projects that contribute a rich repository of data on aging-related urinary and vaginal symptoms, aging-related changes in physical and mental function, and associated quality of life in older community-dwelling women. She will address new research questions about relationships between changes in urinary incontinence, physical performance, psychological function, and sleep quality and disruption in older women in response to behavioral, physical activity-based interventions, using ancillary measures incorporated into one of her recently launched clinical trials. She will develop a new workshop series designed to guide early stage investigators in designing and conducting pilot or feasibility trials. She will also carry out a formal mentoring program with plans for recruitment, development, and evaluation of additional mentees from diverse backgrounds. These plans will make full use of the outstanding research training environment at UCSF and leverage leadership positions that Dr. Huang already holds in multiple NIH-funded training programs to identify and support high-quality mentees with the potential to become leaders in patient-oriented research at the intersection of aging and women’s health.

项目摘要 K24中期职业研究者奖的申请将促进Alison Huang博士的指导， 职业发展在以病人为导向的研究生殖泌尿老化的妇女。黄医生是个将军 内科医生和妇女健康调查员，致力于促进科学理解和改善 管理老龄化对妇女健康，特别是泌尿生殖健康的影响。的资助下 国家老龄化研究所和其他NIH研究所/中心，她领导了一个全国公认的，病人- 一项强调与年龄相关的泌尿生殖系统疾病的共同因素的研究计划 功能障碍和其他常见的衰老综合征，如身体功能下降，认知能力下降， 抑郁焦虑和睡眠中断迄今为止，她的工作创造了新的患者报告结果 在国家和国际老年妇女泌尿生殖健康研究中使用的措施， 指导尿失禁等疾病的诊断和治疗策略的新证据， 泌尿生殖道萎缩、尿失禁和更年期症状。她也成为了一个成功的导师， 发表了高影响力研究的初级临床医生，获得了联邦资助的研究奖项， 继续参与关于老年妇女健康的面向病人的研究。 目前，国家老龄问题研究所没有K24奖支持研究指导 对女性泌尿生殖系统衰老或老年女性健康的影响。因此，黄博士寻求支持， 扩大她对各种有兴趣学习泌尿生殖健康和功能的临床实习生的指导 以及老龄化和更年期对老年妇女健康的影响。她会利用 过去和现在的研究项目，有助于丰富的数据库，对老化相关的泌尿系统， 阴道症状、与年龄相关的身体和精神功能变化以及相关的生活质量， 社区老年妇女。她将提出新的研究问题， 尿失禁、身体表现、心理功能和睡眠质量的变化， 老年妇女对基于行为和体力活动的干预措施的反应中断，使用辅助 她最近启动的一项临床试验中采用了一些措施。她将开发一个新的车间 旨在指导早期研究人员设计和进行试点或可行性试验的系列。她 还将开展一项正式的指导计划，包括招聘、发展和评估计划， 来自不同背景的其他学员。这些计划将充分利用杰出的研究成果 培训环境，并利用黄博士已经在多个 NIH资助的培训计划，以识别和支持有潜力成为 在老龄化和妇女健康的交叉点以病人为导向的研究的领导者。