A simple instrument for in-situ, time-resolved speciated measurement of the 16-EPA priority Polycyclic Aromatic Hydrocarbons.

一种简单的仪器，用于对 16-EPA 优先多环芳烃进行原位时间分辨形态测量。

• 批准号: 10010866
• 负责人: Arantzazu Eiguren Fernandez
• 金额: $ 18.75万
• 依托单位: AEROSOL DYNAMICS, INC.
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-14 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10010866
• 关键词: Address; Air; Aromatic Polycyclic Hydrocarbons; Assessment tool; Atherosclerosis; Breathing; Carcinogens; Cells; Chemicals; Collection; Complex; Custom; Data; Databases; Detection; Devices; Disease; Environment; Exposure to; Feasibility Studies; Gas Chromatography; Gases; Goals; Guidelines; Hazardous Substances; Health; Heating; Human; Human Resources; In Situ; Individual; Infant; International Agencies; Laboratories; Lead; Liver; Malignant Neoplasms; Measurement; Measures; Metabolic Biotransformation; Metals; Methods; Monitor; Morphologic artifacts; Motor Vehicles; National Institute of Environmental Health Sciences; Outcome; Performance; Phase; Poison; Publishing; Recovery; Research; Resolution; Risk Assessment; Sampling; Sensitivity and Specificity; Specificity; System; Techniques; Testing; Time; Tube; United States Environmental Protection Agency; World Health Organization; base; cigarette smoke; cognitive development; cost; detector; exhaust; exposed human population; genotoxicity; instrument; miniaturize; neurodevelopment; particle; performance tests; phase 1 study; photoionization; portability; prenatal exposure; prototype; response; sample collection; temporal measurement; ultrafine particle; vapor; wood smoke

PROJECT SUMMARY People are exposed to Polycyclic Aromatic Hydrocarbons (PAHs) regularly. PAHs are ubiquitous in our environments, and long-term exposure can lead to many adverse health diseases, including cognitive and neural development delay in infants (prenatal exposure), atherosclerosis, liver problems and cancer. Developing a simple instrument capable of providing semi-continuous levels of ambient PAH will fill the gap of temporal variability data in exposure assessment studies and could provide accurate information to increase our understanding of the effect of PAHs in adverse health outcomes.

项目总结 人们经常接触多环芳烃(PAHs)。多环芳烃在我们的生活中无处不在 环境和长期暴露可导致许多不利的健康疾病，包括认知和 婴儿神经发育迟缓(产前暴露)、动脉粥样硬化、肝脏问题和癌症。 开发一种能够提供环境多环芳烃半连续水平的简单仪器将填补 暴露评估研究中的时间变异性数据，并可提供准确的信息，以增加 我们对多环芳烃在不良健康后果中的影响的理解。