A Rodent Physiologic Analysis and Recording System

啮齿动物生理分析和记录系统

• 批准号: 10009486
• 负责人: Brian R Clark
• 金额: $ 73.75万
• 依托单位: BARRON ASSOCIATES, INC.
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-15 至 2023-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10009486
• 关键词: Ammonia; Animal Model; Animals; Applications Grants; Architecture; Archives; Area; Behavior; Carbon Dioxide; Charge; Computer software; Conscious; Custom; Data; Data Collection; Data Display; Data Sources; Databases; Development; Devices; Docking; Dorsal; Engineering; Environment; Environmental Monitoring; Estrogen receptor positive; Evaluation; Freedom; Future; Gases; Goals; Graph; Heart Rate; Humidity; Internet; Laboratory Animal Production and Facilities; Lithium; Measurement; Measures; Modality; Monitor; Motion; Mus; Network Communication Protocols; Operative Surgical Procedures; Phase; Physiological; Polymers; Process; Protocols documentation; Rattus; Research; Research Design; Research Personnel; Resistance; Rodent; Running; Sampling; Schedule; Skin Temperature; Small Business Innovation Research Grant; Software Design; Suction; Surface; System; Tablet Computer; Tablets; Technology; Temperature; Time; Validation; Vertebrates; Veterinarians; Visual; Wireless Technology; analog; animal care; base; behavioral study; cost; data access; data streams; design; experimental study; implantation; improved; instrumentation; light weight; monitoring device; non-Native; non-invasive monitor; novel; open source; programs; prototype; remote sensor; respiratory; response; sensor; tool; usability; virtual; wireless communication; wireless network

Project Summary/Abstract The proposed research program focuses on the development and validation of the Rodent Physiologic Analysis and Recording (RODAR) System. The RODAR system embodies a wireless, noninvasive data collection, vi- sualization, and storage solution for monitoring animals' physiological status, behavior, and environment. The RODAR system o ers continuous or intermittent recording, synchronization, and real-time display of physiologic data including: heart rate, respiratory rate, activity, and skin temperature, and environmental data including: ambient temperature, humidity, ammonia, carbon dioxide, and other gases. The system also includes wireless \bridge" modules that will allow third-party or custom-made sensors to be integrated seamlessly into the wireless RODAR framework. Physiologic data are collected via miniature, lightweight Remote Physiologic Modules (RPMs) that are worn on the dorsal surface of the animal, with sensors integrated into an adjustable, chew-resistant jacket with a minimal form factor. The jacket is easily placed on the animal and features a rechargeable battery that can be replaced without removing the jacket. Both washable and disposable varieties of jacket will be available. Environmental data are collected using wireless, chew-proof Remote Environment Modules (REMs) that can be placed in living quarters or experimental environments. Remote Bridge Modules (RBMs) will be available that can accept arbitrary analog inputs (e.g., from third-party or custom sensors) and seamlessly integrate such data with native RODAR sensors. This capability allows a wide range of sensing modalities to operate as \nodes" wirelessly within the RODAR framework. All data collected by the RPMs, REMs, and RBMs are automatically time synchronized by the system. The RODAR system will enable simultaneous monitoring of up to 72 remote sensor modules (any combination of RPMs, REMs, and/or RBMs). Wireless videographic cameras can also be used with the RODAR system to enable visual monitoring and recording of the animals in real time. All RODAR remote unit data are transmitted wirelessly to a common receiver unit called the Hub. The Hub synchronizes the incoming data streams and relays the consolidated data to a PC using a standard network communications protocol. The PC can be local or remote, allowing experimental data to be viewed in real time from anywhere with an Internet connection. Software designed from the ground-up to be highly usable by researchers, technicians, and veterinarians provides both real-time and retrospective display of data, performs any additional processing that is desired, archives received data in a standard database format, and allows data collection protocols to be selected for the remote units. The RODAR system is a powerful, scalable, and extensible wireless architecture for noninvasive monitoring of animals' physiological status, behavior, and environmental conditions; it is also designed to facilitate the integration of additional sensor modalities as such technologies become available.

项目总结/摘要 该研究计划的重点是啮齿动物生理分析的开发和验证 RODAR系统（RODAR）RODAR系统体现了无线、非侵入性数据收集， 用于监测动物的生理状态、行为和环境的稳定化和储存溶液。的 RODAR系统可连续或间歇记录、同步和实时显示生理信息 数据包括：心率、呼吸率、活动和皮肤温度，以及环境数据，包括： 环境温度、湿度、氨、二氧化碳和其它气体。该系统还包括无线 “桥”模块，将允许第三方或定制的传感器无缝集成到无线 RODAR框架。 生理数据通过微型、轻便的远程生理模块（RPM）收集， 在动物的背部表面上，传感器集成到可调节的耐咀嚼夹克中， 最小的形状因子。这件夹克很容易套在动物身上，它的特点是有一个可充电电池， 更换时不需脱下外套。可水洗和一次性夹克都有。 环境数据通过无线防咀嚼远程环境模块（REM）收集， 放置在生活区或实验环境中。远程桥接模块（RBM）将提供， 可以接受任意模拟输入（例如，从第三方或定制传感器），并无缝集成这些数据 用原生的RODAR传感器这种能力允许广泛的传感模态作为\节点\” 在RODAR框架内进行无线传输。RPM、REM和RBM收集的所有数据均自动 时间由系统同步。RODAR系统将能够同时监测多达72个远程 传感器模块（RPM、REM和/或RBM的任意组合）。无线摄像机也可以 与RODAR系统一起使用，以实现对动物的真实的实时视觉监测和记录。 所有RODAR远程单元数据都无线传输到称为集线器的公共接收器单元。的 集线器将传入的数据流合并，并使用标准网络将合并后的数据中继到PC 通信协议。PC可以是本地的或远程的，允许在真实的中查看实验数据 从任何地方与互联网连接的时间。软件设计从头开始， 研究人员、技术人员和兽医提供实时和回顾性的数据显示， 所需的任何附加处理，以标准数据库格式存档接收到的数据，并允许数据 要为远程单元选择的收集协议。 RODAR系统是一种功能强大、可扩展和可扩展的无线架构，用于无创监测 动物的生理状态，行为和环境条件;它也旨在促进 随着这些技术变得可用，可以集成附加的传感器模态。