A novel instrument for continuous blood pressure monitoring

一种新型连续血压监测仪器

基本信息

  • 批准号:
    10696510
  • 负责人:
  • 金额:
    $ 30.97万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-06-01 至 2025-05-31
  • 项目状态:
    未结题

项目摘要

Project Summary/Abstract Problem High blood pressure (BP) is a substantial public health problem that affects 45% of adults (75% of individuals over age 65) and is a leading cause of excess cardiovascular morbidity and mortality. BP monitoring has high diagnostic and prognostic value as an important marker of cardiovascular disease. Static BP snapshots, which are typically obtained via sphygmomanometry during doctor’s office visits, have documented reliability issues, including “white-coat” hypertension and poor technique. Auscultatory or oscillometric cuff-based ambu- latory BP monitors (ABPMs) that can be worn in home settings and provide regular automated measurements over 24-hour periods have seen widespread adoption. However, these devices also suffer from poor reliability because measurements are seldom performed according to the specified guidelines even with training (e.g., seated, feet not crossed, arm cuff maintained at heart level, etc.). They also yield only intermittent measure- ments (potentially missing important BP events), worsen sleep quality due to their intrusiveness, confound BP measurements due to autonomic response to cuff inflations, and are obtrusive and uncomfortable. Solution The proposed Blood Pressure Sage (BP-SAGE ) system will be a novel, reliable, easy-to-use, and comfortable (non-cuff-based) continuous ABPM (cABPM) that can operate 24/7, even during activities of daily living (ADL) and sleep without disturbing or requiring any action from the wearer, and without imposing stringent measurement guidelines. This new class of BP monitor will be an important addition to clinical practice, accurately and unobtrusively assessing individuals with established or suspected hypertension, even during movement and without uncom- fortable cuff inflations. BP-SAGE will provide accurate BP estimates without restricting users’ mobility, body postures, or arm elevations. The beat-to-beat BP estimates may be used directly or averaged over arbitrary intervals (e.g., to reproduce conventional ABPM results). The Phase I effort will demonstrate proof-of-concept and feasibility for the BP-SAGE methodology via rigorous evaluation in both healthy and hypertensive subjects. In particular, BP-SAGE systolic, diastolic, and mean arterial BP estimates will be obtained during rest and at different BP levels and compared to criterion BP measurements obtained using a laboratory-grade continuous noninvasive BP (cNIBP) monitor. As a true pulse transit time (PTT)-based technique, and based on the proposed novel modeling approach that also accounts for variations in vasomotor tone, BP-SAGE will obviate the need for repeated calibrations associated with traditional pulse arrival time (PAT)-based methods. BP-SAGE software will automatically generate clear, interpretive reports that meet international standards and include summary data to simplify interpretation by clinicians. BP-SAGE will fulfill the need for an ergonomic, accurate, reliable, and low-cost continuous BP monitoring for use in healthcare and clinical research.
项目总结/摘要 高血压(BP)是一个严重的公共卫生问题,影响45%的成年人(75%的人)。 年龄超过65岁的个体),并且是过度心血管发病率和死亡率的主要原因。BP监测 作为心血管疾病的重要标志物,具有较高的诊断和预后价值。静态血压快照, 通常在医生办公室访问期间通过血压测量获得, 问题,包括“白大褂”高血压和技术差。基于听诊或听诊袖带的ambu- 可在家庭环境中佩戴并提供定期自动测量的测量血压仪(ABPM) 超过24小时的周期已经被广泛采用。然而,这些装置也遭受差的可靠性 因为即使在训练的情况下也很少根据指定的指导方针执行测量(例如, 坐着,脚不交叉,臂袖保持在心脏水平等)。它们也只能产生间歇性的测量- 事件(可能错过重要的BP事件),由于其侵入性而使睡眠质量恶化,混淆BP 由于对袖带充气的自主响应,测量结果不一致,并且是突兀的和不舒服的。 解决方案所提出的血压圣人(BP-SAGE)系统将是一种新颖,可靠,易于使用, 舒适的(非袖带式)连续ABPM(cABPM),可全天候运行,即使在 日常生活(ADL)和睡眠,而不干扰或需要佩戴者的任何动作,并且不强加于 严格的测量准则。 这种新的血压监测类将是一个重要的除了临床实践,准确和不显眼 评估已确诊或疑似高血压的个体,即使在运动期间, 舒适的袖带充气。BP-SAGE将提供准确的BP估计,而不会限制用户的移动性,身体 姿势或手臂抬高。逐拍BP估计可以直接使用或在任意时间段上平均。 间隔(例如,再现常规ABPM结果)。 第一阶段的工作将通过严格的测试来证明BP-SAGE方法的概念验证和可行性。 在健康和高血压受试者中进行评估。特别是,BP-SAGE收缩、舒张和平均动脉 将在休息期间和不同BP水平下获得BP估计值,并与标准BP测量值进行比较 使用实验室级连续无创BP(cNIBP)监测仪获得。作为一个真正的脉搏传导时间 (PTT)为基础的技术,并基于所提出的新的建模方法,也占的变化, 血管紧张素,BP-SAGE将消除与传统脉搏到达相关的重复校准的需要 时间(PAT)方法。BP-SAGE软件将自动生成符合以下要求的清晰、解释性报告: 国际标准,并包括总结数据,以简化临床医生的解释。BP-SAGE将满足 需要人体工程学的、准确的、可靠的和低成本的连续BP监测用于医疗保健, 临床研究

项目成果

期刊论文数量(0)
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Brian R Clark其他文献

EXPERIMENTAL HYPOTHYROIDISM: RELATIONSHIP BETWEEN CEREBELLAR CELL DIVISION AND ENZYMES INVOLVING NUCLEIC ACID METABOLISM DURING DEVELOPMENT
  • DOI:
    10.1203/00006450-197704000-00264
  • 发表时间:
    1977-04-01
  • 期刊:
  • 影响因子:
    3.100
  • 作者:
    Morton E Weichsel;Brian R Clark;Russell E Poland
  • 通讯作者:
    Russell E Poland
RELATION OF THYMIDYLATE SYNTHETASE (TS) ACTIVITY TO DNA ACCUMULATION RATE IN DEVELOPING RAT CEREBELLUM: EFFECT OF HYPER- AND HYPOTHYROIDISM
  • DOI:
    10.1203/00006450-197704000-00209
  • 发表时间:
    1977-04-01
  • 期刊:
  • 影响因子:
    3.100
  • 作者:
    Brian R Clark;Morton E Weichsel
  • 通讯作者:
    Morton E Weichsel
Pyrimidine Metabolism during Restorative Brain Growth after Neonatal Undernutrition in the Rat
大鼠新生儿营养不良后恢复性脑生长期间的嘧啶代谢
  • DOI:
    10.1203/00006450-197704000-00007
  • 发表时间:
    1977-04-01
  • 期刊:
  • 影响因子:
    3.100
  • 作者:
    Morton E Weichsel;Brian R Clark
  • 通讯作者:
    Brian R Clark

Brian R Clark的其他文献

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{{ truncateString('Brian R Clark', 18)}}的其他基金

A Novel Instrument to Address Freezing of Gait in Parkinson's Patients
一种解决帕金森病患者步态冻结的新型仪器
  • 批准号:
    10323757
  • 财政年份:
    2021
  • 资助金额:
    $ 30.97万
  • 项目类别:
An Instrument to Assess the Functional Impact of Chronic Pain
评估慢性疼痛功能影响的工具
  • 批准号:
    10436545
  • 财政年份:
    2019
  • 资助金额:
    $ 30.97万
  • 项目类别:
A Rodent Physiologic Analysis and Recording System
啮齿动物生理分析和记录系统
  • 批准号:
    10009486
  • 财政年份:
    2018
  • 资助金额:
    $ 30.97万
  • 项目类别:
A system to detect fall occurrence and location in hospital settings
检测医院环境中跌倒事件和位置的系统
  • 批准号:
    9343403
  • 财政年份:
    2017
  • 资助金额:
    $ 30.97万
  • 项目类别:
A system to detect fall occurrence and location in hospital settings
检测医院环境中跌倒事件和位置的系统
  • 批准号:
    10461967
  • 财政年份:
    2017
  • 资助金额:
    $ 30.97万
  • 项目类别:
A system to detect fall occurrence and location in hospital settings
检测医院环境中跌倒事件和位置的系统
  • 批准号:
    10323706
  • 财政年份:
    2017
  • 资助金额:
    $ 30.97万
  • 项目类别:
SoundTrak: A Data Acquisition and Analysis System for OSDB
SoundTrak:OSDB 数据采集和分析系统
  • 批准号:
    8779945
  • 财政年份:
    2014
  • 资助金额:
    $ 30.97万
  • 项目类别:
BENEFIT
益处
  • 批准号:
    8454000
  • 财政年份:
    2009
  • 资助金额:
    $ 30.97万
  • 项目类别:
Bayesian Fall Risk Assessment Instrument
贝叶斯跌倒风险评估仪
  • 批准号:
    7611258
  • 财政年份:
    2009
  • 资助金额:
    $ 30.97万
  • 项目类别:
BENEFIT
益处
  • 批准号:
    8594211
  • 财政年份:
    2009
  • 资助金额:
    $ 30.97万
  • 项目类别:

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