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Quantitative systems pharmacology approach to identify cytoprotective agents and pathways for Huntington's Disease

Quantitative systems pharmacology approach to identify cytoprotective agents and pathways for Huntington's Disease
定量系统药理学方法识别亨廷顿病的细胞保护剂和途径
批准号：
10011415
负责人：
Anton Simeonov
金额：
$13.27万
依托单位：
NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10011415
关键词：
Biological MarkersCell SurvivalCellsCritical PathwaysCytoprotective AgentDiseaseGoalsHuntington DiseaseHuntington geneModelingNeuronal DysfunctionNeuronsPharmacologyReportingSystemTestingTherapeuticmutantneuron losspolyglutaminesmall molecule

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英文摘要
The collaborative team aims to identify relevant biomarkers and previously unrecognized therapeutic strategies for HD by integrating diverse experimental and computational strategies. During this period, the collaborative team screened compounds for protective activity in cells harboring expanded polyglutamine Htt. A focus was placed on testing compounds with reported targets and mechanism(s) of action. Using a quantitative systems pharmacology approach, the collaborative team aims to uncover cellular pathways that are critical for cell survival in Huntingtons disease.
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