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Capacitive carbon-nanotube composite eye tracking sensor for non-human primate oculomotor research

用于非人类灵长类动物动眼神经研究的电容式碳纳米管复合眼球追踪传感器

基本信息

批准号：
10039483
负责人：
Jae-Hyun Chung
金额：
$ 27.47万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-01 至 2022-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10039483
关键词：
3D Print Address Animal Experimentation Animal Testing Animals Area Augmented Reality Awareness Callithrix Carbon Nanotubes Characteristics Development Devices Dimensions Electric Capacitance Electromagnetic Fields Electronics Engineering Eye Eye Movements Face Feeds Fracture Frequencies Generations Geometry Goals Goggles Head Hybrids Implant Industry Lasers Light Manufacturer Name Measurement Measures Miniaturization Morphologic artifacts Movement Neurons Noise Operative Surgical Procedures Optics Paper Performance Physiologic pulse Positioning Attribute Research Saccades Shapes Signal Transduction Smooth Pursuit Stretching Surface System Techniques Technology Testing Time Transducers Update Virtual and Augmented reality Vision analog base clinical application design detector digital double walled carbon nanotube experimental study instrumentation kinematics neurophysiology nonhuman primate novel oculomotor operation optogenetics prototype sensor signal processing soft tissue temporal measurement visual processing visual tracking voltage

项目摘要

Project Summary/Abstract The accuracy and timely execution of rapid saccadic eye movements are crucial for effective vision. Therefore, an accurate measure of where the eye is aimed is required to understand not only the effect on visual processing but also the neuronal mechanisms that underlie the generation of the eye movements themselves. For more than 40 years, much of our understanding of the oculomotor system has relied on the scleral search coil system. This system has the advantages of operating in real time and having low noise and high accuracy. However, it requires an invasive surgery to implant the eye coil and bulky high power AC electromagnetic field coils. Unfortunately, as far as we are aware, there are no longer manufacturers that supply the scleral search coil system. The shifting focus of the electronics industry toward digital switching technology obsoletes most linear parts required to build the power oscillator that feeds the field coils and the detector. The optical eye movement transducers, which do not require attachment to the eye, are limited by the long latency of their video processing. Also, the fast high-end devices suffer from ringing artifacts at the end of a saccade that may mislead the interpretation of saccade kinematics. These problems could be a barrier for a new oculomotor neurophysiology lab. With the recent development of optogenetics, a technique that allows light to manipulate the activity of specific neurons with high temporal precision and then examine the effects on eye movements, the availability of an eye tracking device with a real-time characteristics is necessary. This real-time, low latency requirement is necessary in a closed-loop optogenetics experiment in which the laser light pulse is triggered and modulated by the kinematics of the eye movement while a saccade is unfolding. To address the need for a non-contact eye movement transducer with high spatial and temporal resolution, we propose to develop an eye tracking device that senses the asymmetric geometry of the ocular globe. The device will be based on a capacitive sensor that measures the proximity between the globe and the sensor. A capacitive proximity sensor has a wide bandwidth in excess of 1MHz and the signal processing stage can be designed using small-signal analog/digital circuits that allow for real-time operation. The capacitance sensor is composed of a fractured carbon nanotube-paper composite (CPC). Unlike other planar capacitive sensors, the fractured CPC relies on the total surface area resulting from the stretching of numerous multi-walled carbon nanotubes (MWCNTs). The surface area of MWCNT networks can be large enough to provide measurements that are orders of magnitude more sensitive than that of planar capacitors. The performance of the proposed sensor will be evaluated in a non-human primate and compared to that of a scleral search coil system.

项目总结/文摘