Neuronal mechanisms of human episodic memory

人类情景记忆的神经机制

• 批准号: 10044948
• 负责人: Adam Nathaniel Mamelak
• 金额: $ 163.65万
• 依托单位: CEDARS-SINAI MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-30 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10044948
• 关键词: Animal Model; Area; Attention; BRAIN initiative; Behavior; Behavioral; Behavioral Model; Binding; Brain; Cells; Child; Clip; Cognition; Cognitive; Communities; Computer Analysis; Computer Models; Data; Data Set; Decision Making; Detection; Development; Disease; Electric Stimulation; Electrodes; Epilepsy; Episodic memory; Ethics; Etiology; Event; Fostering; Foundations; Goals; Human; Implant; Implanted Electrodes; Infrastructure; Intractable Epilepsy; Investigation; Knowledge; Light; Link; Maintenance; Medial; Memory; Memory Disorders; Methods; Modeling; Nervous system structure; Neurons; Neurosciences; Ocular Physiology; Operative Surgical Procedures; Outcome; Patients; Physiology; Procedures; Process; Property; Research; Retrieval; Role; Short-Term Memory; Signal Transduction; Site; Source Code; Standardization; Stimulus; Structure; System; Techniques; Temporal Lobe; Testing; Time; TimeLine; Translating; Work; awake; base; design; experience; experimental study; flexibility; in vivo; innovation; insight; long term memory; meetings; memory recall; memory recognition; memory retrieval; movie; multidisciplinary; neural patterning; neuromechanism; neurophysiology; novel; programs; relating to nervous system; response; visual tracking

Project Summary The rapid formation of new memories and the recall of old memories to inform decisions is essential for human cognition, but the underlying neural mechanisms remain poorly understood. The long-term goal of this research is a circuit-level understanding of human memory to enable the development of new treatments for the devastating effects of memory disorders. Our experiments utilize the rare opportunity to record in-vivo from human single neurons simultaneously in multiple brain areas in patients undergoing treatment for drug resistant epilepsy. The overall objective is to continue and expand a multi-institutional (Cedars-Sinai/Caltech, Johns Hopkins, U Toronto, Children's/Harvard, UC Denver, UCSB), integrated, and multi-disciplinary team. Jointly, we have the expertise and patient volume to test key predictions on the neural substrate of human memory. We will utilize a combination of (i) in-vivo recordings in awake behaving humans assessing memory strength through confidence ratings, (ii) focal electrical stimulation to test causality, and (iii) computational analysis and modeling. We will apply these techniques to investigate three overarching hypotheses on the mechanisms of episodic memory. First, we will determine the role of persistent neuronal activity in translating working memories into long- term declarative memories (Aim 1). Second, we will determine how declarative memories are translated into decisions (Aim 2). Third, we will investigate how event segmentation, temporal binding and reinstatement during temporally extended experience facilitate episodic memory. The expected outcomes of this work are an unprecedented characterization of how episodic memories are formed, retrieved and used for decisions, and how temporally extended experiences are segmented to form distinct but linked episodes. This work is significant because we move beyond a “parts list” of neurons and brain areas by testing circuit-based hypotheses by simultaneously recording single-neurons from multiple frontal cortical and subcortical temporal lobe areas in humans who are forming, declaring and describing their memories. The proposed work is unusually innovative because we combine single-neuron recordings in multiple areas in behaving humans, develop new methods for non-invasive localization of implanted electrodes and electrical stimulation and directly test long-standing theoretical predictions on the role of evidence accumulation in memory retrieval. A second significant innovation is our team, which combines the patient volume and expertise of several major centers to maximally utilize the rare neurosurgical opportunities available to directly study the human nervous system. This innovative approach permits us to investigate circuit-level mechanisms of human memory that cannot be studied non-invasively in humans nor in animal models. This integrated multi-disciplinary combination of human in-vivo single-neuron physiology, behavior, and modeling will contribute significantly to our understanding of the circuits and patterns of neural activity that give rise to human memory, which is a central goal of human neuroscience in general and the BRAIN initiative in particular.

项目总结