Project 1 - Defining the structure and function of NTS satiety circuits

摘要项目1-项目1：定义NTS饱和度电路的结构和功能 虽然最近许多能量平衡导向的研究都集中在下丘脑 这些下丘脑系统主要通过后脑回路介导它们对进食的影响。 此外，许多最有效的药物肥胖治疗作用于脑干 饱足感系统不经意间产生的恶心症状，如恶心，这是 由脑干饱腹感系统混合的回路介导，代表了 然而，靶向这些系统的治疗的最重要的限制。因此， 为了区分编码饱腹感的脑干回路和那些促进恶心和其他疾病的脑干回路， 厌恶症状，因为非厌恶回路代表治疗的理想目标。 这个项目将定义NTS控制进食的神经回路， 它发出厌恶或非厌恶反应的信号，视刺激情况而定。除了 增强我们对控制摄食行为的重要神经系统的理解， 区分非厌恶性饱腹感系统和厌恶性饱腹感系统可以允许设计改进的饱腹感系统。 减少食物摄入和对抗肥胖的疗法。

Abstract Project 1- Project 1: Defining the structure and function of NTS satiety circuits While much recent energy balance-directed research has focused upon hypothalamic circuits, these hypothalamic systems largely mediate their effects on feeding via hindbrain circuits. Furthermore, many of the most effective pharmacological obesity treatments act on brainstem satiety systems. The inadvertent production of aversive symptoms such as nausea, which is mediated by circuits that are intermingled with brainstem satiety systems, represents one of the most important limitations to therapies that target these systems, however. Thus, it will be crucial to distinguish the brainstem circuits that encode satiety from those that promote nausea and other aversive symptoms, since the non-aversive circuits represent ideal targets for therapy. This project will define the neural circuits by which the NTS controls feeding and by which it signals aversive or non-aversive responses, as appropriate for the stimulus. In addition to enhancing our understanding of neural systems important for the control of ingestive behavior, distinguishing non-aversive from aversive satiety systems may permit the design of improved therapies to decrease food intake and combat obesity.